Sesamol Reduces the Atherogenicity of Electronegative L5 LDL <i>in Vivo</i> and <i>in Vitro</i>

Chen, Wei Yu; Chen, Fang Yu; Lee, An‐Sheng; Ting, Kuan Hsiang; Chang, Chia Ming; Hsu, Jing‐Fang; Lee, Wei Shine; Sheu, Joen Rong; Chen, Chu Huang; Shen, Ming-Yi

doi:10.1021/np500700z

Cited by 34 publications

(27 citation statements)

References 50 publications

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“…Study 6 stated that SO treatment was not significantly different from the control treatment, which supported that the beneficial effects resulting from treatment with N-acetylcysteine (NAC) and SO together was only due to NAC; there was not enough SO to counteract the high cholesterol diet, which implies that SO treatment may be dose dependent. Other studies also agree that their research results that indicate the benefits of SO were truly significant at a certain dose [ 33 - 35 ]. Plant studies showed that plant stanols decreased LDL levels in a dose-dependent manner up to ~17% in a linear fashion when given up to 9 grams/milliliter [ 40 ].…”

Section: Reviewsupporting

confidence: 67%

Anti-inflammatory and Antioxidant Effects of Sesame Oil on Atherosclerosis: A Descriptive Literature Review

Hsu

Parthasarathy

2017

Cureus

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Sesame oil (SO) is a supplement that has been known to have anti-inflammatory and antioxidant properties, which makes it effective for reducing atherosclerosis and the risk of cardiovascular disease. Due to the side effects of statins, the current recommended treatment for atherosclerosis and cardiovascular diseases, the idea of using dietary and nutritional supplementation has been explored. The benefits of a dietary health regime have piqued curiosity because many different cultures have reaped health benefits through the ingredients in their cooking with negligible side effects. The purpose of this literary review is to provide a broad overview of the potential benefits and risks of SO on the development of atherosclerosis and its direction toward human clinical use. Current in vivo and in vitro research has shed light on the effects of SO and its research has shown that SO can decrease low-density lipoprotein (LDL) levels while maintaining high-density lipoprotein (HDL) levels. Current limitations in recent studies include no standardized doses of SO given to subjects and unknown specific mechanisms of the different components of SO. Future studies should explore possible synergistic and adverse effects of SO when combined with current recommended pharmaceutical therapies and other adjunct treatments.

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Section: Reviewsupporting

confidence: 67%

Anti-inflammatory and Antioxidant Effects of Sesame Oil on Atherosclerosis: A Descriptive Literature Review

Hsu

Parthasarathy

2017

Cureus

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“…Study of the sesamol effect on Syrian hamsters fed a high-fat diet demonstrated that the compound addition could reduce plasma L5 levels and atherosclerotic lesion size. 94 These results encourage the search for compounds specifically targeting the electronegative LDL fraction and related signaling. In another study, the authors demonstrated a decrease of LDL(–) uptake by macrophages and foam cell formation caused by anti-LDL(–) single-chain variable antibody fragments (scFv).…”

Section: Clinical Importance Of the Ldl Electronegativity Index In Prmentioning

confidence: 95%

LDL electronegativity index: a potential novel index for predicting cardiovascular disease

Ivanova

Bobryshev

Orekhov³

2015

VHRM

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High cardiovascular risk conditions are frequently associated with altered plasma lipoprotein profile, such as elevated low-density lipoprotein (LDL) and LDL cholesterol and decreased high-density lipoprotein. There is, however, accumulating evidence that specific subclasses of LDL may play an important role in cardiovascular disease development, and their relative concentration can be regarded as a more relevant risk factor. LDL particles undergo multiple modifications in plasma that can lead to the increase of their negative charge. The resulting electronegative LDL [LDL(–)] subfraction has been demonstrated to be especially atherogenic, and became a subject of numerous recent studies. In this review, we discuss the physicochemical properties of LDL(–), methods of its detection, atherogenic activity, and relevance of the LDL electronegativity index as a potential independent predictor of cardiovascular risk.

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“…Because LDL(−) and L5 circulate in human plasma, they have also been studied for their harmful effects in patients with chronic kidney disease 24 , patients undergoing dialysis 25 , and patients with systemic inflammation 26 , 27 . Furthermore, treatment with statins 18 , 28 , 29 or sesamol 30 has been shown to decrease the plasma level of LDL(−) or L5, respectively, and attenuate their inflammatory and apoptotic effects.…”

Section: Introductionmentioning

confidence: 99%

Range of L5 LDL levels in healthy adults and L5’s predictive power in patients with hyperlipidemia or coronary artery disease

Chu

Chan²,

Tsai³

et al. 2018

Sci Rep

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Electronegative L5 low-density lipoprotein (LDL) level may be a useful biomarker for predicting cardiovascular disease. We determined the range of plasma L5 levels in healthy adults (n = 35) and examined the power of L5 levels to differentiate patients with coronary artery disease (CAD; n = 40) or patients with hyperlipidemia (HLP) without evidence of CAD (n = 35) from healthy adults. The percent L5 in total LDL (L5%) was quantified by using fast-protein liquid chromatography with an anion-exchange column. Receiver operating characteristic curve analysis was performed to determine cut-off values for L5 levels. The mean L5% and plasma concentration of L5 (ie, [L5]) were significantly higher in patients with HLP or CAD than in healthy adults (P < 0.001). The ranges of L5% and [L5] in healthy adults were determined to be <1.6% and <1.7 mg/dL, respectively. In individuals with L5% >1.6%, the odds ratio was 9.636 for HLP or CAD. In individuals with [L5] >1.7 mg/dL, the odds ratio was 17.684 for HLP or CAD. The power of L5% or [L5] to differentiate patients with HLP or CAD from healthy adults was superior to that of the LDL/high-density lipoprotein ratio. The ranges of L5% and [L5] in healthy adults determined here may be clinically useful in preventing and treating cardiovascular disease.

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Sesamol Reduces the Atherogenicity of Electronegative L5 LDL in Vivo and in Vitro

Cited by 34 publications

References 50 publications

Anti-inflammatory and Antioxidant Effects of Sesame Oil on Atherosclerosis: A Descriptive Literature Review

Anti-inflammatory and Antioxidant Effects of Sesame Oil on Atherosclerosis: A Descriptive Literature Review

LDL electronegativity index: a potential novel index for predicting cardiovascular disease

Range of L5 LDL levels in healthy adults and L5’s predictive power in patients with hyperlipidemia or coronary artery disease

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