Sesquiterpene lactones and other constituents from Stevia jorullensis

Pérez-Castorena, Ana L.; Nieto‐Camacho, Antonio; Maldonado, Emma

doi:10.1016/j.bse.2020.104003

Cited by 3 publications

(1 citation statement)

References 32 publications

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“…These sesquiterpene lactones were reported for the first time in the Stevia genus. Additionally, chlorogenic acid ( 53 ), β-sitosterol ( 54 ), stigmasterol ( 9 ), β-sitosteryl glucopyranoside ( 55 ), and stigmasteryl glucopyranoside ( 56 ) were also isolated [ 29 ].…”

Section: Phytochemistrymentioning

confidence: 99%

Stevia Genus: Phytochemistry and Biological Activities Update

et al. 2021

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The Stevia genus (Asteraceae) comprises around 230 species, distributed from the southern United States to the South American Andean region. Stevia rebaudiana, a Paraguayan herb that produces an intensely sweet diterpene glycoside called stevioside, is the most relevant member of this genus. Apart from S. rebaudiana, many other species belonging to the Stevia genus are considered medicinal and have been popularly used to treat different ailments. The members from this genus produce sesquiterpene lactones, diterpenes, longipinanes, and flavonoids as the main types of phytochemicals. Many pharmacological activities have been described for Stevia extracts and isolated compounds, antioxidant, antiparasitic, antiviral, anti-inflammatory, and antiproliferative activities being the most frequently mentioned. This review aims to present an update of the Stevia genus covering ethnobotanical aspects and traditional uses, phytochemistry, and biological activities of the extracts and isolated compounds.

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Section: Phytochemistrymentioning

confidence: 99%

Stevia Genus: Phytochemistry and Biological Activities Update

et al. 2021

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Chemical constituents from Cortex Moutan and their chemotaxonomic significance

Du,

Wu,

Yin

et al. 2024

Biochemical Systematics and Ecology

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Anticancer Potential of Aguerin B, a Sesquiterpene Lactone Isolated from Centaurea behen in Metastatic Breast Cancer Cells

Amini

Nabiuni

Behzad

et al. 2020

PRA

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Background: Breast carcinoma is a malignant disease that represents the most common non-skin malignancy and a chief reason of cancer death in women. Large interest is growing in the use of natural products for cancer treatment, especially with goal of suppression angiogenesis, tumor cell growth, motility, as well as invasion and metastasis with low/no toxicity. It is evident from recent patents on the anticancer properties of sesquiterpene lactones such as parthenolide. Objective: In this study, using MDA-MB-231 cells of a human breast adenocarcinoma, the effects of aguerin B, as a natural sesquiterpene lactone, has been evaluated, in terms of the expression of metastatic-related genes (Pak-1, Rac-1 and HIF-1α). Methods: Cytotoxicity of aguerin B was tested toward MDA-MB-231 breast tumor cells using MTT. Scratch assay was accomplished to evaluate the tumor cell invasion. To understand the underlying molecular basis, the mRNA expressions were evaluated by real time PCR. Results: It was found that aguerin B significantly inhibited human breast cancer cell growth in vitro (IC50 = 2µg/mL) and this effect was accompanied with a persuasive suppression on metastasis. Our results showed that aguerin B in IC50 concentration down-regulated Rac-1, Pak-1, Hif-1α and Zeb-1 transcriptional levels. Conclusion: Taken together, this study demonstrated that aguerin B possessed potential anti-metastatic effect, suggesting that it may consider as a potential multi target bio compound for treatment of breast metastatic carcinoma.

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Sesquiterpene lactones and other constituents from Stevia jorullensis

Cited by 3 publications

References 32 publications

Stevia Genus: Phytochemistry and Biological Activities Update

Stevia Genus: Phytochemistry and Biological Activities Update

Chemical constituents from Cortex Moutan and their chemotaxonomic significance

Anticancer Potential of Aguerin B, a Sesquiterpene Lactone Isolated from Centaurea behen in Metastatic Breast Cancer Cells

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