Sesquiterpene lactones from Centaurea tweediei

The traditional Hungarian medicinal plant Centaurea sadleriana Janka accelerates wound healing in rats

“…The most characteristic compounds identified in Centaurea are sesquiterpene lactones of germacranolide, elemanolide (Wagner, 1977), guaianolide (Akkol et al, 2009b) and eudesmanolide type (Fortuna et al, 2001). Further important and characteristic classes of compounds in this genus are polyacetylenes, flavonoids (flavones, flavonols, flavanones and flavanonols) and other phenolic compounds (characteristically cinnamic acid derivatives) (Wagner, 1977).…”

Rearrangement of Germacranolides. Synthesis and Absolute Configuration of Elemane and Heliangolane Derivatives from Cnicin

“…To the best of our knowledge, compound 14 has not been described previously, although similar heliangolides have been isolated from Centaurea tweediei [10] and Centaurea paui. [11] The former has a different ester moiety, and the latter has a methyleneacetoxy group at C-4 instead of the aldehyde.…”

“…Therefore, we assigned to this compound the structure 13, with a heliangolide skeleton, confirmed also by the 13 C NMR spectrum (Table 2) and the literature data. [10] The acetonide group of compound 13 was then removed to give 14.…”

“…Centaurea paui, [9,11] Centaurea tweediei [10] ) could be artifacts generated from unstable 15-oxo-germacranolides during extraction and/or purification procedures. At this point there is no clear answer to this and more investigation is required.…”

Bio-guided identification of an anti-inflammatory guaianolide fromCentaurea ainetensis

“…Extensive chemical investigations of Centaurea species led to the isolation and identification of various types of compounds, including alkaloids (Sarker et al, 2001), lignans (Aslan & Oksuz, 1999;Kumarasamy et al, 2003), acetylenes, flavonoids (Akkal et al, , 1999(Akkal et al, , 2003Aslan & Oksuz, 1999;de Almeida et al, 1998;Flamini et al, 2001Flamini et al, , 2002, and sesquiterpene lactones (Aslan & Oksuz, 1999;Bruno et al, 2002;Chaves & De Oliviera, 2003;Fortuna et al, 2001Fortuna et al, , 2002Helal et al, 1997;Medjroubi et al, 1997Medjroubi et al, , 1998Oksuz et al, 1994;Skaltsa et al, 2000;Vajs et al, 1999;Youssef, 1998). It has been reported that the most characteristic constituents of the genus Centaurea are sesquiterpene lactones, which are classified into guaianolides, the most abundant in this genus, followed by germacranolides, elemenolides, and finally eudesmanolides (Skaltsa et al, 2000).…”