Sesquiterpene lactones from Lychnophora species: Antinociceptive, anti-inflammatory, and antioxidant pathways to treat acute gout

Bernardes, Ana Catharina Fernandes Pereira Ferreira; Matosinhos, Rafaela Cunha; Araújo, Marcela Carolina de Paula Michel; Barros, Camila Helena; Aguiar-Soares, Rodrigo Dian de Oliveira; Costa, Daniela Caldeira; Sachs, Daniela; Saúde-Guimarães, Dênia Antunes

doi:10.1016/j.jep.2020.113738

Cited by 18 publications

(8 citation statements)

References 31 publications

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“…Sesquiterpene lactones, a member of the terpene family, have important roles as pharmaceutical agents due to their many biological and therapeutic potentials such as antioxidant, antinociceptive, anti-cancer, and antiinflammatory [21][22][23] . Farnesene (FNS) is a sesquiterpene lactone present in various plants and foods, with a wide range of biological effects.…”

Section: Introductionmentioning

confidence: 99%

Otoprotective effects of farnesene against oxidative damage induced by paclitaxel

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2022

Cukurova Medical Journal

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Amaç: Bu çalışmanın amacı, güçlü serbest radikal süpürücü ve antioksidan özelliklere sahip farnesenin paklitaksel kaynaklı ototoksisite üzerindeki etkilerini biyokimyasal ve fonksiyonel yönden araştırmaktır. Gereç ve Yöntem: On sekiz erkek Wistar albino sıçan, altı sıçandan oluşan üç gruba rastgele ayrıldı. Araştırma boyunca kontrol grubuna paklitaksel veya farnesen verilmedi. Paklitaksel grubuna, 5mg/kg paklitaksel intraperitoneal olarak dört kez (1., 7., 14. ve 21. günlerde) verildi. Farnesen + paklitaksel grubuna, önce 5 mg/kg paklitaksel, 30 dakika sonra 50 mg/kg farnesen intraperitoneal olarak 4 kez (1., 7., 14. ve 21. günlerde) verildi. 0. ve 21. günlerde tüm sıçanların otoakustik emisyon ölçümü yapıldı. Daha sonra hayvanlar sakrifiye edildi ve biyokimyasal testler için kokleaları çıkarıldı. Bulgular: Paklitaksel, önemli ölçüde malondialdehit seviyelerini yükselterek ve glutatyon seviyelerini düşürerek kokleada oksidatif strese neden oldu. Ayrıca paklitaksel grubunun distorsiyon ürünü otoakustik emisyon değerleri diğer gruplara göre anlamlı derecede düşüktü. Farnesen+paklitaksel grubunda ise paklitakselin çeşitli biyokimyasal ve fonksiyonel parametrelerde oluşturduğu hasarda iyileşmeler gözlendi. Sonuç: Çalışma sonuçları doğal bir antioksidan olan farnesen’in sıçanlarda paklitaksel kaynaklı işitme kaybını azalttığını, farnesen ve paklitaksel kombinasyonunun gelecekte klinik kullanım için paklitaksel kaynaklı ototoksisiteden koruyabileceğini göstermektedir.

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Section: Introductionmentioning

confidence: 99%

Otoprotective effects of farnesene against oxidative damage induced by paclitaxel

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2022

Cukurova Medical Journal

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“…When plants are on the border between two biomes, like Cerrado (Brazilian Savanna) and Atlantic Forest, the production and accumulation of these sesquiterpene lactones is ampli ed (Gobbo-Neto et al 2010), which reinforces a strong correlation of defense against possible environmental effects (Ahern and Whitney 2014). As already mentioned for some species of Lychnophora, such as L. passerine and L. trichocarpha, the activity is directly related to the presence of lactones (Bernardes et al 2021) nevertheless, in L. salicifolia, popularly known as "Arnicão", there are no reports of accumulations of lactones, only the same previous discussed phenolic active compounds.…”

Section: Introductionmentioning

confidence: 83%

“…Generally, the in vivo anti-in ammatory action is attributed to the sesquiterpene lactones (Ugoline et al 2017). Sesquiterpene lactones isolated from other Lychnophora species exhibit an anti-in ammatory effect by neutrophil migration inhibition and TNF-α production in addition to antinociceptive activity (Bernardes et al 2021). However, in cellular models, the binding of goyazensolide derivatives with the cysteine residue of glutathione was observed through a reaction similar to Michael's addition.…”

Section: Introductionmentioning

confidence: 99%

Mapping Cutaneous Tissue Distribution of Sesquiterpene Lactone Goyazensolide Using MALDI Imaging

Lopes,

Kato,

Buqui

et al. 2024

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Species of Lychnophora, popularly known in Brazil as "Arnica-da-serra", are widely used in topical preparations as analgesics and anti-inflammatories. The most commonly used species is Lychnophora ericoides, and studies of seasonal and circadian rhythms show greater stability for phenolic constituents than for sesquiterpene lactones (an opposite behavior was observed). These lactones are considered defensive substances; thus, they were found in significant quantities in border regions between two biomes, at least for L. ericoides. Herbalists often report that seasonality influences on the increase of lactone levels in leaves and may have increase the allergenic potential. In the present study, we sought to develop a methodology for imaging tissues treated with solutions of the sesquiterpene lactone goyazensolide to observe skin retention using the Franz cell model. To this end, MALDI-MS parameters were optimized for imaging generation, and an LC-MS/MS protocol was used to confirm goyazensolide skin retention. The obtained data revealed that sesquiterpene lactones strongly bind to the skin structure.

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“…Recently, an in vivo study using lychnopholide, eremantholide C, and goyazensolide, three sesquiterpene lactones extracted from Lychnophora species, were assessed regarding their anti-inflammatory actions, using a monosodium urate (MSU) crystal-induced arthritis C57BL/6 mice animal model. The tested SL exerted anti-inflammatory effects by inhibiting neutrophil migration and blocking the release of TNF-α [ 54 ]. Budlein A, a SL from Viguiera robusta , presented an in vivo response in a model of acute gout arthritis in mice.…”

Section: Sesquiterpene Lactones In Medicine: Immunoregulatory Respons...mentioning

confidence: 99%

Anti-Inflammatory and Immunoregulatory Action of Sesquiterpene Lactones

et al. 2022

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Sesquiterpene lactones (SL), characterized by their high prevalence in the Asteraceae family, are one of the major groups of secondary metabolites found in plants. Researchers from distinct research fields, including pharmacology, medicine, and agriculture, are interested in their biological potential. With new SL discovered in the last years, new biological activities have been tested, different action mechanisms (synergistic and/or antagonistic effects), as well as molecular structure–activity relationships described. The review identifies the main sesquiterpene lactones with interconnections between immune responses and anti-inflammatory actions, within different cellular models as well in in vivo studies. Bioaccessibility and bioavailability, as well as molecular structure–activity relationships are addressed. Additionally, plant metabolic engineering, and the impact of sesquiterpene lactone extraction methodologies are presented, with the perspective of biological activity enhancement. Sesquiterpene lactones derivatives are also addressed. This review summarizes the current knowledge regarding the therapeutic potential of sesquiterpene lactones within immune and inflammatory activities, highlighting trends and opportunities for their pharmaceutical/clinical use.

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Sesquiterpene lactones from Lychnophora species: Antinociceptive, anti-inflammatory, and antioxidant pathways to treat acute gout

Cited by 18 publications

References 31 publications

Otoprotective effects of farnesene against oxidative damage induced by paclitaxel

Otoprotective effects of farnesene against oxidative damage induced by paclitaxel

Mapping Cutaneous Tissue Distribution of Sesquiterpene Lactone Goyazensolide Using MALDI Imaging

Anti-Inflammatory and Immunoregulatory Action of Sesquiterpene Lactones

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