Sesquiterpene lactones from the aerial parts of Vernonia blumeoides growing in Nigeria

Aliyu, A. B.; Moodley, Brenda; Chenia, Hafizah Y.; Koorbanally, Neil A.

doi:10.1016/j.phytochem.2014.11.010

Cited by 7 publications

(2 citation statements)

References 22 publications

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“…The 1 H and 13 C NMR spectroscopic data suggested that 3 has a eudesmanolide skeleton similar to known analogues. 36,37 The 1 H, 13 C, and HSQC NMR data for 3 supported the presence of four carbonyl groups (δ C 207.5, 174.6, 169.0, 165.4), four olefinic carbons (an exomethylene, δ C 120.2/δ H 6.18; 5.47 and a methine δ C 137.5/δ H 6.72 and the two respective quaternary carbons, δ C 133.4 and 134.0), four oxymethines, two oxymethylenes, one sp 3 quaternary carbon, four methines, two methylenes, and four methyl groups (Table 1). The core structure of the eudesmanolide skeleton was determined by analysis of the COSY and HMBC data.…”

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confidence: 99%

Antiprotozoal Sesquiterpene Lactones and Other Constituents from Tarchonanthus camphoratus and Schkuhria pinnata

Kimani¹,

Matasyoh

Kaiser

et al. 2017

J. Nat. Prod.

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In continuation of a search for new antiprotozoal agents from plants of the family Asteraceae, Tarchonanthus camphoratus and Schkuhria pinnata have been investigated. By following the promising in vitro activity of the dichloromethane extracts from their aerial parts, bioassay-guided chromatographic isolation yielded two known sesquiterpene lactones (1 and 2) from T. camphoratus and 20 known compounds of this type from S. pinnata. From the latter, a new eudesmanolide, (1R*,5S*,6R*,7R*,8R*,10R*)-1-hydroxy-8-[5″-hydroxy-4'-(2″-hydroxyisovaleroyloxy)tigloyloxy]-3-oxoeudesma-11(13)-en-6,12-olide (3), and two new germacranolides, 3β-(2″-hydroxyisovaleroyloxy)-8β-(3-furoyloxy)costunolide (14) and 1(10)-epoxy-3β-hydroxy-8β-[5'-hydroxy-4'-(2″-hydroxyisovaleroyloxy)tigloyloxy]costunolide (16), were obtained. Additionally, the flavonoid pectolinarigenin (24) and 3-hydroxy-4,5-dimethoxybenzenepropanol (25) were also isolated from S. pinnata. The compounds were characterized by analysis of 1D and 2D NMR spectroscopic and HR/MS data. In vitro antitrypanosomal activity and cytotoxicity against mammalian cells (L6 cell line) were evaluated for all the compounds. Santhemoidin A (13) and 3β-(2″-hydroxyisovaleroyloxy)-8β-(3-furoyloxy)costunolide (14) were the most active compounds found in this study, with IC values of 0.10 and 0.13 μM against Trypanosoma brucei rhodesiense trypomastigotes and selectivity indices of 20.5 and 29.7, respectively.

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confidence: 99%

Antiprotozoal Sesquiterpene Lactones and Other Constituents from Tarchonanthus camphoratus and Schkuhria pinnata

Kimani¹,

Matasyoh

Kaiser

et al. 2017

J. Nat. Prod.

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“…Its crude extract exhibited various treatments for diarrhea and malaria. One of the eudesmanolide sesquiterpene lactones—blumeoidolide-A ( 16 ), isolated from the aerial parts of this plant, demonstrated limited but interesting antibacterial activity against B. subtilis ATCC 6633 and two Staphylococcus strains [ 34 ] ( Table 1 ).…”

Section: Isolationmentioning

confidence: 99%

Antimicrobial Activity of Lactones

Mazur

Masłowiec

2022

Antibiotics

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The development of bacterial resistance to antibiotics and the consequent lack of effective therapy is one of the biggest problems in modern medicine. A consequence of these processes is an urgent need to continuously design and develop novel antimicrobial agents. Among the compounds showing antimicrobial potential, lactones are a group to explore. For centuries, their antimicrobial activities have been used in folk medicine. Currently, novel lactone compounds are continuously described in the literature. Some of those structures exhibit high antimicrobial potential and some are an inspiration for design and synthesis of future drugs. This paper describes recent developments on antimicrobial lactones with smaller ring sizes, up to seven membered ε-lactones. Their isolation from natural sources, chemical synthesis, synergistic activity with antibiotics, and effects on quorum sensing are presented herein.

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Identification and antimicrobial activity of the sesquiterpene lactone mixture extracted from Smallanthus sonchifolius dried leaves

Andrade

Carpiné

Dagostin

et al. 2017

Eur Food Res Technol

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Sesquiterpene lactones from the aerial parts of Vernonia blumeoides growing in Nigeria

Cited by 7 publications

References 22 publications

Antiprotozoal Sesquiterpene Lactones and Other Constituents from Tarchonanthus camphoratus and Schkuhria pinnata

Antiprotozoal Sesquiterpene Lactones and Other Constituents from Tarchonanthus camphoratus and Schkuhria pinnata

Antimicrobial Activity of Lactones

Identification and antimicrobial activity of the sesquiterpene lactone mixture extracted from Smallanthus sonchifolius dried leaves

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