Sesquiterpene lactones from Tithonia diversifolia act as peroxisome proliferator-activated receptor agonists

Lin, Hsiang‐Ru

doi:10.1016/j.bmcl.2012.02.043

Cited by 43 publications

(31 citation statements)

References 21 publications

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“…Furthermore, through in vitro studies using HepG2 cells, it is known that the compounds of the sesquiterpene lactone, thyrotundin and tagitinin A, can increase the activity of peroxisome proliferator-activated receptors (PPARs) γ which is to increase insulin sensitivity (Lin, 2012). Sesquiterpene lactones from Tithonia diversifolia plant also proved to increase glucose uptake in 3T3-L1 adipocyte cell cultures with glucose exposure (Zhao, Li, Chen, Xi, & Sun, 2012).…”

Section: Resultsmentioning

confidence: 99%

Ethanol Extract of Tithonia diversifolia (Hemsley) A Gray Standardized Ameliorates Hyperglycemia, Polyphagia, and Weight Loss in Diabetic Rats

Fauziyah¹,

Sunarti²,

Hanoum³

et al. 2018

Molekul

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Diabetes mellitus is a state of chronic hyperglycemia which causes various complications. Traditionally, The Tithonia diversifolia (Hemsley) A Gray leaf has long been used for the treatment of diabetes. The aim of this study is to investigate the effect of the T. diversifolia leaf on blood glucose, polyphagia, and weight loss in a diabetic rat model. Rats were made diabetic with intraperitonial injection of Nicotinamide and Streptozotocin and divided into 5 groups. Group 1 were healthy rats, group 2 were diabetic rats, while groups 3, 4, and 5 were diabetic rats treated with 25, 50, and 100 mg/kg body weight of 70% ethanol extract of Tithonia diversifolia leaf respectively for 28 days. Blood was taken after treatment for measuring glucose. The ethanol extract of T. diversifolia leaf decreased blood glucose in diabetic rats (P<0.05). The ethanol extract of T. diversifolia leaf significantly suppresses polyphagia and improves diabetic rat weight (P <0.05). In conclusion, Tithonia diversifolia ethanolic extract has anti-hyperglycemic effect and ameliorated the effect of diabetes mellitus symptoms, namely polyphagia and weight loss.

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Section: Resultsmentioning

confidence: 99%

Ethanol Extract of Tithonia diversifolia (Hemsley) A Gray Standardized Ameliorates Hyperglycemia, Polyphagia, and Weight Loss in Diabetic Rats

Fauziyah¹,

Sunarti²,

Hanoum³

et al. 2018

Molekul

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“…Several biological activities have been described for most of these compounds (Liao et al, , 2013Chagas-Paula et al, 2011, 2012Lin, 2012;Zhao et al, 2012;Sánchez-Mendoza et al, 2011;Gu et al, 2002). The tested STL from T. diversifolia usually exhibit expected biological activity because, in a general way, they are known for their key medicinal potential (Chagas-Paula et al, 2012; Ghantous et al, 2010).…”

Section: Discussionmentioning

confidence: 98%

“…Among the terpenoids, the sesquiterpene lactones (STL) comprise the most studied class because they are frequently the major compounds present in active extracts and fractions from leaves and flowers (Chagas-Paula et al, 2012). Although STL are plant-derived compounds with remarkable antiinflammatory and antitumor activity, they are usually known for their toxic properties (Chagas-Paula et al, 2011, 2012Merfort, 2011;Ghantous et al, 2010;Schmidt, 1999). Among all compounds from T. diversifolia already tested for biological activity, the tagitinins (Tags), STL, have shown relevant activity in diverse pathologic situations (Chagas-Paula et al, 2012;Gu et al, 2002;Liao et al, 2011;Sánchez-Mendoza et al, 2011;Zhao et al, 2012).…”

Section: Introductionmentioning

confidence: 98%

Anti-inflammatory sesquiterpene lactones from Tithonia diversifolia trigger different effects on human neutrophils

Abe¹,

Oliveira²,

Dalboni³

et al. 2015

Revista Brasileira de Farmacognosia

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a b s t r a c tThe tagitinins isolated of Tithonia diversifolia (Hemsl.) A. Gray, Asteraceae, are the most studied sesquiterpene lactones due to their wide spectrum of pharmacologic activities, especially related with nuclear factor-kappa B inhibition. Nevertheless, detailed studies about the mechanism of action of its active compounds are still lacking. Neutrophils perform a fundamental role in the inflammatory response to several etiologic factors. However, the effect of tagitinins on human neutrophil is not yet clearly known. We investigated the role of tagitinin C (1), tagitinin F (2) and tagitinin A (3) in activation and survival of human neutrophils to establish possible effects in their mechanisms of inflammation. Human neutrophils were purified from the peripheral blood and cultivated with tagitinins C (1), F (2) and A (3) in the presence or not of Escherichia coli lipopolysaccharide. The enzymatic activity, apoptosis and secretion of cytokines rate were determined after 18 h. Lipopolysaccharide-induced myeloperoxidase activity of human neutrophils was significantly inhibited only by tagitinin F (2). Apoptosis of neutrophils was increased in the presence of tagitinin C (1), and it occurred independently of the presence of lipopolysaccharide or dexamethasone. Tagitinins C (1), F (2) and A (3) decrease lipopolysaccharide-induced interleukin-6, interleukin-8 and Tumor necrosis factor alpha production by human neutrophils. Together, these results indicate that tagitinins exhibit anti-inflammatory action on human neutrophils. However, tagitinin F (2) was the only sesquiterpene lactone that decreased secretion of inflammatory products by neutrophils without inducing neutrophil apoptosis.

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“…Several natural products have been suggested to be dual PPARα/γ agonists [45]. Tirotundin and tagitinin A are sesquiterpene lactones derived from Tithonia diversifolia (a traditional Chinese medicine used for treating diabetes), which have been suggested to be dual PPARα/γ agonists [73], along with rosmarinic acid [71], daidzein, genistein and formononetin [74] (Table 6.1). However, more evidence is required to demonstrate their antidiabetic effects and their molecular mechanism.…”

Section: Natural Products That Modulate the Action Of Pparγmentioning

confidence: 99%

Discovery of Natural Products that Modulate the Activity of PPARgamma: A Source for New Antidiabetics

2014

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Sesquiterpene lactones from Tithonia diversifolia act as peroxisome proliferator-activated receptor agonists

Cited by 43 publications

References 21 publications

Ethanol Extract of Tithonia diversifolia (Hemsley) A Gray Standardized Ameliorates Hyperglycemia, Polyphagia, and Weight Loss in Diabetic Rats

Ethanol Extract of Tithonia diversifolia (Hemsley) A Gray Standardized Ameliorates Hyperglycemia, Polyphagia, and Weight Loss in Diabetic Rats

Anti-inflammatory sesquiterpene lactones from Tithonia diversifolia trigger different effects on human neutrophils

Discovery of Natural Products that Modulate the Activity of PPARgamma: A Source for New Antidiabetics

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