Sesquiterpenes from <i>Fissistigma glaucescens</i> inhibiting the proliferation of synoviocytes

Wu, You; Zhu, Cheng-Cong; Luo, Yu-Xi; Zhang, Bin; Ji, Xin-Shu; Xia, Song; Zhou, Xue-Ming

doi:10.1080/10286020.2021.1949300

Cited by 8 publications

(1 citation statement)

References 12 publications

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“…Many Annona species have been largely studied due to their medicinal properties and their specific contents of bioactive secondary metabolites [ 2 ]. This is the case for the genus Fissistigma , which includes diverse plants used in traditional medicine, such as Fissistigma glaucescens , F. polyanthoides , F. retusum , and others, mainly distributed in tropical areas of Asia [ 3 , 4 ]. Among these plants, the species F. oldhamii has received less attention thus far.…”

Section: Introductionmentioning

confidence: 99%

Fissistigma oldhamii (Hemsl.) Merr.: Ethnomedicinal, Phytochemistry, and Pharmacological Aspects

Bailly

2023

Plants

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The species Fissistigma oldhamii (Hemsl.) Merr. (Annonaceae) has long been used as a traditional herbal medicine in China to treat diverse human diseases. Decoctions from the roots of the plant (Guā Fù Mù) are used to treat body pain and inflammatory pathologies, such as rheumatic syndromes, sciatica, and osteoarthritis. The phytochemical content of the plant and the associated pharmacological activities have been analyzed. Seventy natural products were identified in the different parts of the plants, namely, the roots, stems, leaves, fruits, and seeds. The compounds comprise many tri- and tetracyclic alkaloids (aporphine-type), anthraquinones, terpenoids, flavonoids, and others. The pharmacological properties of these molecules were analyzed to point out the anti-inflammatory, antioxidant, anticancer, and/or antimicrobial effects, together with the underlying modulated pathways and molecular targets in some cases. The panel of phytoconstituents present in F. oldhamii extracts is large, with the majority of bioactive products identified in the roots and stems. Multiple molecules can contribute to the anti-inflammatory properties of the extracts. Network pharmacology analyses of the phytoconstituents are needed to better delineate the effective components and their targets.

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Section: Introductionmentioning

confidence: 99%

Fissistigma oldhamii (Hemsl.) Merr.: Ethnomedicinal, Phytochemistry, and Pharmacological Aspects

Bailly

2023

Plants

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Four New Polyhydroxy Cyclohexanes from the Stems of Fissistigma tientangense

Chen

Zhang

et al. 2023

Chemistry & Biodiversity

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Four undescribed polyhydroxy cyclohexanes, fissoxhydrylenes A-D (1 -4), together with two known biogenetically related polyhydroxy cyclohexanes (5 and 6) were isolated from the stems of Fissistigma tientangense Tsiang et P. T. Li. Their structures were elucidated by detailed analysis of NMR, HR-ESI-MS, IR, UV and Optical rotations data. The absolute configuration of 1 was confirmed by X-ray crystallographic. The absolute configurations of 2-4 were confirmed by chemical reaction and optical rotations. Compound 4 represent the first example of a no substituent polyhydroxy cyclohexanes from natural products. All isolated compounds were evaluated for their anti-inflammatory activities against the lipopolysaccharide-induced nitric oxide (NO) production in mouse macrophage RAW 264.7 cells in vitro. Compounds 3 and 4 showed inhibitory activities with the IC 50 values of 16.63 � 0.06 μM and 14.38 � 0.08 μM, respectively.

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Guaiane‐Type Sesquiterpenes from the Stems of Fissistigma oldhamii

Zhang

et al. 2023

Chemistry & Biodiversity

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Two new guaiane-type sesquiterpenes dysodensiols J and L, one new natural product dysodensiol K together with four known biogenetically related guaiane-type sesquiterpenes were isolated from the stems of Fissistigma oldhamii. Their structures were elucidated by detailed analysis of NMR, HR-ESI-MS, IR and Optical rotations data. Compound 1 contains an uncommon five-membered ether ring. The inhibitory effect of all compounds on the proliferation of primary synovial cells was evaluated. Compound 3 showed inhibitory activity with an IC 50 value of 6.8 μM. Compounds 5-7 exhibited moderate inhibitory activity with IC 50 values of 23.8, 26.6, and 27.1 μM, respectively.

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Sesquiterpenes from Fissistigma glaucescens inhibiting the proliferation of synoviocytes

Cited by 8 publications

References 12 publications

Fissistigma oldhamii (Hemsl.) Merr.: Ethnomedicinal, Phytochemistry, and Pharmacological Aspects

Fissistigma oldhamii (Hemsl.) Merr.: Ethnomedicinal, Phytochemistry, and Pharmacological Aspects

Four New Polyhydroxy Cyclohexanes from the Stems of Fissistigma tientangense

Guaiane‐Type Sesquiterpenes from the Stems of Fissistigma oldhamii

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