Sesquiterpenes from the leaves of Nicotiana tabacum and their anti-tobacco mosaic virus activity

Shen, Qinpeng; Xu, Xingmeng; Li, Lan; Zhao, Wei; Xiang, Neng-Jun; Yang, Guangyu; Yongkuan, Chen; Ming-ming, Miao; Liu, Chunbo; Liu, Zhihua

doi:10.1016/j.cclet.2016.01.048

Cited by 23 publications

(15 citation statements)

References 25 publications

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“…Compounds 342 and 343 showed the highest anti-TMV activity with 36.7% and 45.6% inhibiation rates as compared to the positive control ningnanmycin at 31.5% inhibition rates. The other compounds were active at rates of 22.7–29.2% . Three sesquiterpens, tabasesquiterpenes A ( 346 ), B ( 347 ), and C ( 348 ), balsamiferine ( 349 ), samboginone ( 350 ), and ent -4(15)-eudesman-1α,11-diol ( 351 ) have been isolated from the leaves of N.…”

Section: Metabolite Classes: Structures and Functionsmentioning

confidence: 99%

Ecological Roles and Biological Activities of Specialized Metabolites from the GenusNicotiana

Jassbi¹,

Zare²,

Asadollahi³

et al. 2017

Chem. Rev.

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Species of Nicotiana grow naturally in different parts of the world and have long been used both medicinally and recreationally by human societies. More recently in our history, Nicotiana tabacum has attracted interest as one of the most economically important industrial crops. Nicotiana species are frequently investigated for their bioactive natural products, and the ecological role of their specialized metabolites in responses to abiotic stress or biotic stress factors like pathogens and herbivores. The interest of tobacco companies in genetic information as well as the success of a few wild tobacco species as experimental model organisms have resulted in growing knowledge about the molecular biology and ecology of these plants and functional studies of the plant's natural products. Although a large number of reviews and books on biologically active natural products already exists, mostly from N. tabacum, we focus our attention on the ecological roles and biological activity of natural products, versus products from cured and processed material, in this Review. The studied compounds include alkaloids, aromatic compounds, flavonoids, volatiles, sesquiterpenoids, diterpenes alcohols, and sugar esters from trichomes of the plants, and recently characterized acyclic hydroxygeranyllinalool diterpene glycosides (HGL-DTGs). In this Review (1800s-2017), we describe the above-mentioned classes of natural products, emphasizing their biological activities and functions as they have been determined either in bioassay-guided purification approaches or in bioassays with plants in which the expression of specific biosynthetic genes has been genetically manipulated. Additionally, a review on the history, taxonomy, ecology, and medicinal application of different Nicotiana species growing around the globe presented in this Review may be of interest for pharmacognosists, natural products, and ecological chemists.

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Section: Metabolite Classes: Structures and Functionsmentioning

confidence: 99%

Ecological Roles and Biological Activities of Specialized Metabolites from the GenusNicotiana

Jassbi¹,

Zare²,

Asadollahi³

et al. 2017

Chem. Rev.

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“…[20][21][22][23] Various plants possess antiviral factors. 12,24 Natural-product-based antiviral agents are active against plant, animal, and human viruses, 30 and furthermore have the ability to decompose rapidly, thereby reducing the risk to the environment. 25,26 Actinidia chinensis is regionally distributed in the Qinling Mountains, Shaanxi Province, China.…”

Section: Discussionmentioning

confidence: 99%

“…ACRB extracts and isolated compounds for the experiment were obtained as described in Section 2.4. The positive control, an 8% aqueous solution of ningnanmycin, 12 was purchased from a local agricultural materials market (Deqiang Biological Co. Ltd, Harbin, China).…”

Section: Introductionmentioning

confidence: 99%

Antiphytoviral toxins of Actinidia chinensis root bark (ACRB) extract: laboratory and semi‐field trials

Zhang

Zhou

Wei

et al. 2018

Pest Management Science

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“…Nicosesquiterpene A and B are novel sesquiterpenes, which showed inhibition rates of 36.7% and 45.6%, respectively (Shen et al, 2016). Other novel sesquiterpenes such as nicotianasesterpenes A and B or tabasesquiterpenes A-C (Shang et al, 2016) were more efficient than NNM, showing inhibition rates in the range of 34-35%.…”

Section: Natural Productsmentioning

confidence: 98%

Chemical Outbreak for Tobacco Mosaic Virus Control

Luvisi¹,

Panattoni²,

Materazzi³

et al. 2017

IJAB

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Tobacco mosaic virus (TMV) represents a paradigm in virology, and its control may open the way to effective treatment against phytoviruses. However, the use of chemicals to eliminate the virus from infected plants is very difficult. In this state of the art survey we include trials on a) natural compounds derived from organisms, b) synthetic compounds and c) plant or microorganism extracts, from 2006 to 2015. Plants have been the main source of natural products for anti-TMV tests in the last ten years, and Nicotiana tabacum was the main focus of research, particularly between 2014-2015. Since 2012, there has been a great increase in publications (+45%) and identified compounds (+241%). Between 2012-2015, an average of 31 papers were published and 140 compounds were tested each year, compared to 9 papers and 26 compounds in 2006-2011. Unfortunately, there is little information on the action mechanisms of newly discovered or modified compounds. Cross references to the basic structure of compounds is provided in this review. This chemical outbreak this massive interest in chemical solutions to TMV could be due to the increasing availability of instruments for the analysis of organic compounds. Alternatively Another explanation could be that the chemistry advances in synthesis, which have provided countless drugs with potential benefits for TMV control, have overwhelmed overloaded the plant pathology screening needed to discriminate between compounds and to provide useful agrochemicals for farmers.

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Sesquiterpenes from the leaves of Nicotiana tabacum and their anti-tobacco mosaic virus activity

Cited by 23 publications

References 25 publications

Ecological Roles and Biological Activities of Specialized Metabolites from the GenusNicotiana

Ecological Roles and Biological Activities of Specialized Metabolites from the GenusNicotiana

Antiphytoviral toxins of Actinidia chinensis root bark (ACRB) extract: laboratory and semi‐field trials

Chemical Outbreak for Tobacco Mosaic Virus Control

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