Sesquiterpenoid Derivatives from Ferula ferulioides. IV.

Kojima, Keisuke; Isaka, Kimio; Purev, Ondognii; Jargalsaikhan, Gonbovanjilin; Suran, Dagdangin; Mizukami, Hajime; Ogihara, Yukio

doi:10.1248/cpb.48.353

Cited by 39 publications

(36 citation statements)

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“…In traditional medicine, Asafoetida plant is used against seizures, worms, neural diseases, intestinal dysmotility, renal pain, rheumatism, muscular clench, and hypertension, and for elimination of fatty foods' harms, as well as for enhancing appetite and memory (Lee et al, 2009;Leung, 1996;Mohammadi, 2009;Sadraei et al, 2003). Asafoetida has di-, tri-, and tetra-sulfide, coumarin derivatives, camuonephrole, episamarcandine, amblipernine, carnephrole, azafoetidine, froxolicin, azafoetidinole, saradaferine, and foetidine (Abd El-Razek et al, 2001;Bandyopadhyay, 2006;Banerji et al, 1998;Fraga, 1999;Kajimoto et al, 1989;Kojima et al, 2000;Nassar et al, 1995). Eucalyptus has antibacterial, antifungal, antioxidan, anti-infectious, and antispasmatic effects.…”

Section: Discussionmentioning

confidence: 99%

Concise review: Medicinal plants are effective against leishmaniasis

et al. 2017

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Leishmaniasis is an important zoonotic parasitic disease in tropical areas. It is a neglected disease and is a great health catastrophe in Iran. Pentavalent antimony compounds are used for its treatment, but they have adverse effects. Therefore, the use of natural herbs with low adverse effects seems necessary for treatment of Leishmaniasis. In this study, we tried to introduce the natural medicines effective against Leishmaniasis. In this review study, keywords searched included natural medicines, herbal medicines, medicinal plants, Leishmaniasis, and treatment in relevant publications published between 1990 and 2017. Searching was on databases including ISI Web of Science, PubMed, PubMed Central, Scopus, ISC, SID, Magiran and some other databases. The relevant articles were reviewed for the review study. The results showed that medicinal plants: Ferula assafoatida (with IC50 of 0.38 mg/ml), Glycyrrhiza glabra (with IC50 of 25mg/ml), Allium sativum (with IC50 of 0.57 mg/ml), Cephalis ipecacuana (with IC50 of 0.01 mg/ml), Artemisia aucheri (with IC50 of 0.46 mg/ml) and Eucalyptus globulus (with IC50 of 0.17 mg/ml) were the natural medicines effective against the disease. Compositions with di-, tri-,

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Section: Discussionmentioning

confidence: 99%

Concise review: Medicinal plants are effective against leishmaniasis

et al. 2017

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“…Dihydro furo [3,2-c]coumarin and corresponding quinolone skeleton has been a part of many naturally occurring compounds (Figure 1) [18][19][20][21][22]. It is pertinent to mention that dihydro furoquinolones have been found to exhibit broad spectrum of anti-fungal activity [23][24].…”

Section: Introductionmentioning

confidence: 99%

One Pot Three Component Diastereoselective Synthesis of Tricyclic Furoquinolones and Furocoumarins

Naik¹,

Kulkarni²,

Kumar³

et al. 2017

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“…It is also believed to have aphrodisiac properties and increase sexual appetite (Eigner and Scholz 1990). This genus presents interesting phytochemical features, such as the occurrence of sesquiterpenes and sesquiterpene coumarins (Abd El-Razek et al 2001;Kojima et al GRASAS Y ACEITES, 60 (4), JULIO-SEPTIEMBRE, [405][406][407][408][409][410][411][412]2009 …”

Section: Introductionmentioning

confidence: 99%

Antioxidant activity of the methanol extract of <i>Ferula assafoetida</i> and its essential oil composition

et al. 2009

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405(18.2 %), ␣.-Bisabolol (10.4%) and Arsine triethyl (8.7 %). Total phenol compounds, as determined by the Folin Ciocalteu method, were 94.8 Ϯ 5.9 mg gallic acid equivalent/g of extract powder and the total flavonoid content (by AlCl 3 method) was 90.9 Ϯ 6.3 mg quercetin equivalent/g of extract powder.KEY-WORDS: Antioxidant activity -Chelating ability -DPPH -Essential oil -Ferula assafoetida. INTRODUCTIONThe role of free radicals in many disease conditions has been well established. Several biochemical reactions in our body generate reactive oxygen species and these are capable of damaging crucial bio-molecules. If they are not effectively scavenged by cellular constituents, they lead to disease conditions (Halliwell et al. 1992). The harmful action of free radicals can be blocked by antioxidant substances, which scavenge the free radicals and detoxify the organism. Several plant extracts and different classes of phytochemicals have been shown to have antioxidant activity Wang et al. 1996;Zheng and Wang 2001). The search for newer natural antioxidants, especially of plant origin, has been increasing ever since. Plants have been a constant source of drugs and recently, much emphasis has been placed on finding new therapeutic agents from medicinal plants. Today many people prefer to use medicinal plants rather than chemical drugs.The Ferula genus from the family of Umbelliferae has been found to be a rich source of gum-resin (Fernch 1971). This resin enjoys a reputation as a folklore medicine (Abd El-Razek et al. 2001). It is considered to be a sedative, carminative, antispasmodic digestive, expectorant, laxative, analgesic, anthelminitic, antiseptic and a diuretic in its properties. It is also believed to have aphrodisiac properties and increase sexual appetite (Eigner and Scholz 1990 La actividad antioxidante de las partes aéreas de Ferula assafoetida se determinó empleando varios sistemas de ensayos in vitro. El IC 50 de la actividad captadora de radicales de DPPH fue 380 Ϯ 12 mg ml Ϫ1 . Los extractos también mostraron una buena actividad captadora de óxido nítrico (IC 50 fue 270 Ϯ 3) y capacidad quelatante de Fe 2ϩ (IC 50 fue 0.57 Ϯ 0.02 mg ml Ϫ1 ). La inhibición de la peroxidación (actividad antioxidante) de los extractos mostró valores del 82% (a las 24 horas) y 88% (a las 72 horas). El extracto mostró un ligero descenso del poder reductor con 25-800 µg ml Ϫ1 de extracto que no fue comparable con la vitamina C (p Ͻ 0.001). Los extractos ensayados mostraron una muy baja actividad antioxidante. Además, la composición química del aceite esencial de las partes aéreas fue determinada. Los principales compuestos fueron fenol, 2-metil-5-(1-metil etilo) (18.2 %), ␣.-Bisabolol (10.4%) and Arsine trietilo (8.7 %). Los fenoles totales, determinados por el método de Folin-Ciocalteau, fue de 94.8 Ϯ 5.9 mg de equivalentes de ácido gálico/g de extracto en polvo y el contenido total de flavonoides (por el método del AlCl 3 ) fue de 90.9 Ϯ 6.3 mg de equivalentes de quercitina/g de extracto en polvo.PALABRAS CLAVE: Aceite es...

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Sesquiterpenoid Derivatives from Ferula ferulioides. IV.

Cited by 39 publications

References 6 publications

Concise review: Medicinal plants are effective against leishmaniasis

Concise review: Medicinal plants are effective against leishmaniasis

One Pot Three Component Diastereoselective Synthesis of Tricyclic Furoquinolones and Furocoumarins

Antioxidant activity of the methanol extract of <i>Ferula assafoetida</i> and its essential oil composition

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