Sesquiterpenoids from Curcuma wenyujin with anti-influenza viral activities

Jie, Dong; Ma, Xi-Yan; Cai, Xiao-Qin; Yan, Pengcheng; Yue, Lei; Chen, Lin; Shao, Weiwei

doi:10.1016/j.phytochem.2012.09.008

Cited by 45 publications

(21 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chen et C. Ling has been used as an important medicinal plant in China for over 100 years (The State Pharmacopoeia Commission of P. R. China, 2010). C. wenyujin rhizome extract contains a variety of bioactive ingredients, such as curdione (Xia et al, 2012), aurantiamide (Ma et al, 2009;Xia et al, 2012), and sesquiterpene (Sun et al, 2009;Dong et al, 2013;Zhu et al, 2013a). These substances can not only induce apoptosis (Xiao et al, 2008;Lim et al, 2010), inhibit platelet aggregation (Xia et al, 2012), and tumor growth (Sun et al, 2009;Lim et al, 2010), but also serve as clinical agents of anti-oxidation, anti-microbial action (Dong et al, 2013;Zhu et al, 2013b), and anti-inflammation (Tohda et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Conservation and population genetic diversity of Curcuma wenyujin (Zingiberaceae), a multifunctional medicinal herb

et al. 2015

View full text Add to dashboard Cite

ABSTRACT. Curcuma wenyujin is an important multifunctional medicinal herb in China. Currently, populations of C. wenyujin are decreasing, and wild individuals have almost disappeared from their natural habitats. Moreover, little is known regarding the molecular characteristics of this plant. In this study, we investigated the genetic diversity and variation of five populations of C. wenyujin, using random amplified polymorphic DNA (RAPD) and inter-simple sequence repeat (ISSR) markers. We found that the percentages of polymorphic loci (PPL) at the species level (98.25% by RAPD and 100% by ISSR) were significantly higher than those at the population level (66.32% by RAPD and 67.14% by ISSR). The highest values of PPL, expected heterozygosity, and Shannon's information index were in Pop1, while the lowest values were in Pop2. Both DNA markers revealed a short Population genetic diversity of Curcuma wenyujin genetic distance between Pop1 and Pop2 (0.1424 by RAPD and 0.1904 by ISSR). Phylogenetic trees produced similar results, with Pop1, Pop2, and Pop5 in one group and Pop3 and Pop4 in another. There were no significant correlations between their genetic distances and their geographical distances. The highest genetic diversity was in Pop1 and the lowest was in Pop2, and genetic diversity at the species level was relatively low, but much higher than that at the population level. We recommended the establishment of a germplasm bank, in situ conservation, and propagation of wild individuals. The present study will improve the evaluation, protection, and utilization of the population resources of C. wenyujin.

show abstract

Section: Introductionmentioning

confidence: 99%

Conservation and population genetic diversity of Curcuma wenyujin (Zingiberaceae), a multifunctional medicinal herb

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Turmeric is host of medical properties with its wide spectrum of actions 8 such as Antiinflammatory 9 , anti-fungal 10 , anti-mutagenic 11 , anti-carcinogenic 12 , anti-coagulant 13 , antihepatotoxic 14 , anti-fertility 15 , anti-protozoa 16 , anti-viral 17 , anti-fibrotic 18 , anti-venom 19 , antiulcer 20 , anti-hypertensive 21 , anti-diabetic 22,23 and hypo-cholesterolemic 24 / hypo-lipid emic properties 25 .Recently explored uses Alzheimer's disease 26 , Rheumatoid arthritis 27 , Multiple sclerosis 28 , Inflammatory bowel disease 29 , Cataract 30 and HIV 31 .…”

Section: Introductionmentioning

confidence: 99%

Anti-Diabetic Effects of Turmeric in Alloxan Induced Diabetic Rats.

Santoshkumar¹,

Manjunath²,

Mariguddi³

et al. 2013

jemds

View full text Add to dashboard Cite

OBJECTIVE AND BACKGROUND: Turmeric (Curcuma longa) is one of the common constituents of our daily food. The present study was undertaken to evaluate the anti-diabetic effects of ethanolic extract of Rhizomes of curcuma longa in alloxan induced diabetic rats and compared with of Pioglitazone, which is the standard anti-diabetic agent. METHODS: Alloxan monohydrate is used to induce diabetes mellitus in albino rats in the dose of 120mg/kg i.p. and anti-diabetic activity of turmeric was studied by following study design. The rats are divided into 6 groups and each group contains 6 rats (N= 6) as follows. Group I: Normal control Given normal saline (10ml/kg/day). Group II: Diabetic control Given normal saline (10ml/kg/day). Group III: Euglycemic rats Given turmeric extract (300mg/kg/day). Group IV: Diabetic rats Given turmeric extract (300mg/kg/day). Group V: Diabetic control Given turmeric extract (500mg/kg/day). Group VI: Diabetic rats Given Pioglitazone (6mg/kg/day) Study was conducted for a period of 28 days and all the drugs were given orally once daily. Blood glucose levels were estimated at 1, 3, 5, 7 hrs. (acute study) and 7, 14, 21, 28 days (chronic study). The body weights of the rats in every groups recorded weekly and general behavior and health of the animal were monitored carefully. The data was analyzed statistically using student's paired and unpaired t-test. RESULTS: Ethanolic extract of turmeric produced significant (p < 005) decreases in blood glucose levels on 7 th , 14 th , 21 th and 28 days in diabetic

show abstract

“…170 The structure of 1α,8α-epidioxy-4α-hydroxy-5αH-guai-7(11),9-dien-12,8-olide 304, isolated from Curcuma wenyujin with anti-influenza viral activity, has been confirmed by single-crystal X-ray diffraction experiment. 171 The complete relative configuration of the known sesquiterpene (+)-dioxo-sarcoguaiacol has been established. This compound has now been isolated from Acorus calamus.…”

mentioning

confidence: 99%