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Objectives:Clonidine, a known antihypertensive, is currently used for many purposes including diabetic gastroparesis, postmenopausal hot flushes, opioid/nicotine/alcohol withdrawal. Its effects on carbohydrate metabolism appear to be variable. Hence, the present study was undertaken to evaluate the influence of clonidine on euglycemic and alloxan -induced diabetic rats and its interaction with glibenclamide.Materials and Methods:Alloxan - induced (150 mg/kg, i.p) diabetic rats were divided into six groups of six animals each. Group I - Normal Control; Group II - Nondiabetic + Clonidine (25 μg/kg); Group III - Diabetic Control; Group IV - Diabetic + Glibenclamide (5 mg/kg); Group V - Diabetic + Glibenclamide + Clonidine. All drugs were given orally once daily. Blood glucose was estimated from rat tail vein using glucometer before start of the experiment and at the end of 30 days.Results:After 30 days of treatment, clonidine (25 μg/kg) produced significant hyperglycemia in both euglycemic and diabetic rats. It also reduced the hypoglycemic effect of glibenclamide in diabetic rats.Conclusion:The results of present study indicate that clonidine has hyperglycemic effect and it also interacts with glibenclamide to reduce its hypoglycemic activity. If these findings are true to human beings then clonidine should not be used in diabetic patients on sulfonylureas.

Conducting polyaniline/Titanium di-oxide (PANI/TiO2) composites have been synthesized by insitu deposition technique by placing fine graded TiO 2 in polymerization mixture of aniline. The PANI/TiO 2 composites have been synthesized with various compositions viz., 10,20,30,40 and 50 wt % of TiO 2 in PANI. The ac conductivity was studied in the frequency range 10 2 -10 6 Hz. It is observed from the ac conductivity studies that the ac conductivity is found to be constant up to 10 5 Hz and there after it increases steeply which is a characteristic feature of disordered materials. The dielectric behaviour was also investigated in the frequency range 10 2 -10 6 Hz. It is observed from the dielectric studies that the value of dielectric constant decreases up to 20 wt % and later it increases rapidly up to 50 wt %. Similarly it is also seen that the tan δ values decreases rapidly up to 20 wt % and then increases up to 40 wt %, thereafter slowly increases up to 50 wt %. At higher frequencies these composites exhibit almost zero dielectric loss. The dimensions of TiO 2 particles in the matrix have a greater influence on the conductivity values and the observed dielectric values.

OBJECTIVE AND BACKGROUND: Turmeric (Curcuma longa) is one of the common constituents of our daily food. The present study was undertaken to evaluate the anti-diabetic effects of ethanolic extract of Rhizomes of curcuma longa in alloxan induced diabetic rats and compared with of Pioglitazone, which is the standard anti-diabetic agent. METHODS: Alloxan monohydrate is used to induce diabetes mellitus in albino rats in the dose of 120mg/kg i.p. and anti-diabetic activity of turmeric was studied by following study design. The rats are divided into 6 groups and each group contains 6 rats (N= 6) as follows. Group I: Normal control Given normal saline (10ml/kg/day). Group II: Diabetic control Given normal saline (10ml/kg/day). Group III: Euglycemic rats Given turmeric extract (300mg/kg/day). Group IV: Diabetic rats Given turmeric extract (300mg/kg/day). Group V: Diabetic control Given turmeric extract (500mg/kg/day). Group VI: Diabetic rats Given Pioglitazone (6mg/kg/day) Study was conducted for a period of 28 days and all the drugs were given orally once daily. Blood glucose levels were estimated at 1, 3, 5, 7 hrs. (acute study) and 7, 14, 21, 28 days (chronic study). The body weights of the rats in every groups recorded weekly and general behavior and health of the animal were monitored carefully. The data was analyzed statistically using student's paired and unpaired t-test. RESULTS: Ethanolic extract of turmeric produced significant (p < 005) decreases in blood glucose levels on 7 th , 14 th , 21 th and 28 days in diabetic

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