Sesquiterpenoids, hopanoids and bis(bibenzyls) from the Argentine liverwort Plagiochasma rupestre

Bardón, Alicia; Kamiya, Norma; Toyota, Masao; Takaoka, Shigeru; Asakawa, Yoshinori

doi:10.1016/s0031-9422(99)00452-5

Cited by 31 publications

(16 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Dumortiera hirsuta grows on wet rocks and is widespread over China. Previous studies on this species led to the isolation of several novel sesquiterpenoids and some bisbibenzyls [5,6]. In this paper, we report the isolation and characterization of four new monoterpene esters (1-4) from C. conicum in addition to seven known compounds including 5 from C. conicum and 6-11 from D. hirsute.…”

Section: Introductionmentioning

confidence: 89%

Terpenoids and bisbibenzyls from Chinese liverwortsConocephalumconicumandDumortierahirsuta

Fan

et al. 2006

Journal of Asian Natural Products Research

View full text Add to dashboard Cite

Four new monoterpene esters, 2alpha,5beta-dihydroxybornane-2-cinnamate (1), 2alpha,5beta-dihydroxybornane-5-acetyl-2-cinnamate (2), 2alpha,5beta-dihydroxybornane-2-p-hydroxycinnamate (3) and 2alpha,5beta-dihydroxy-bornane-2-cis-p-hydroxycinnamate (4), together with a known compound 3,4-dimethoxystyrene (5) were isolated from Chinese liverwort Conocephalum conicum and six known compounds, 5,7-dihydroxycalamenene (6), 7-hydroxycalamenene (7), lunularin (8), riccardin C (9), marchantin C (10) and riccardin D (11) were isolated from Dumortiera hirsuta. Their structures were elucidated by extensive spectral analysis and chemical correlations. Compounds 1 and 8 showed moderate cytotoxicity against human HepG2 cells with IC50 4.5 microg/ml and 7.4 microg/ml, respectively, while compound 8 also showed antimicrobacterial activity against Pseudomonas aeruginosa with minimum inhibitory concentration at 64 microg/ml.

show abstract

Section: Introductionmentioning

confidence: 89%

Terpenoids and bisbibenzyls from Chinese liverwortsConocephalumconicumandDumortierahirsuta

Fan

et al. 2006

Journal of Asian Natural Products Research

View full text Add to dashboard Cite

show abstract

“…Isolation from liverworts [4] Biological activities [17,18] Total synthesis 6 riccardin C Reboulia hemisphaerica (1982) [9] et al [4] COX inhibition [4] 1990 [27] Ptagiochasm intermedlum (2010) [19] cytotoxic [20,21] 1998 [5] inhibitory activities against HIV-1 RT [21] 2005 [28] inhibition of NOS [22,23] 2009 [25] LXRα agonist but LXRβ antagonist [24,25] antifungal [19] apoptosis of human prostate cancer [26] 8 plagiochin H ---9 isoriccardin C Marchantia polymorpha, M. palmata (1987) [10] COX inhibition [4] Plagiochasma rupestre (1999) [29] Ptagiochasm intermedlum (2010) [19] …”

Section: Namementioning

confidence: 99%

Syntheses of Macrocyclic Bis(bibenzyl) Compounds Derived from Perrottetin E

et al. 2010

View full text Add to dashboard Cite

Macrocyclic bis(bibenzyl) compounds are natural products from liverworts and are of growing interest due to recent reports on new isolated compounds and on their remarkable biological activities. We report here on a flexible and general approach to the total set of nine bis(bibenzyl) compounds of the riccardin and plagiochin type derived from perrottetin E. The structures were confirmed through their spectroscopic data, which were compared carefully with those for the isolated products to exclude any errors in arene connection and substitution pattern.

show abstract

“…) Steph. has been demonstrated to produce sesquiterpenoids and bisbenzyls (Bardón et al 1999). Pinguisone and sesquiterpenes have been isolated from cultures of Aneura pinguis (L.) Dumort.…”

Section: Triandrophyllum Subtrifidum Xmentioning

confidence: 99%

Bioprospecting: A Tool to Conserve Chilean Bryophytes

Cuvertino-Santoni

Montenegro

2013

Gayana Bot.

View full text Add to dashboard Cite

Here, we present the current state of knowledge on the diversity of Chilean bryophytes (mosses, liverworts, and hornworts), the secondary metabolites present in these plants, and the biological activity of extracts from populations of Chilean species. Our goal is to establish the potential of these plants as a source of useful molecules for pharmaceutical and agricultural industries, thus promoting their conservation. Only 3,7% of Chilean bryophytes (55 spp.) have been analyzed using chemical characterization of their extracts (methanol, ether, ethanol, dichloromethane, acetone and hexane). Only four species from Chilean and Argentinian populations (Porella chilensis (Lehm. & Lindenb.) Trevi., Riccardia polyclada (Mitt. ex Thurn) Hässel, Balantiopsis cancellata (Nees) Stephani, and Sphagnum magellanicum Brid.) have been evaluated for biological activity. The majority of these studies have concentrated on liverworts widely distributed in the Southern Hemisphere and in the temperate forests of the southern half of Chile and adjacent Argentina. We briefly discuss aspects related to the use of bioprospecting as a conservation tool as well as the maintenance of in vitro bryophyte cultures with the goal of conservation and production. KEYWORDS:Mosses, liverworts, hornworts, uses, secondary metabolites, biological activity, in vitro cultivation. RESUMENEsta revisión presenta el estado actual del conocimiento de la diversidad de las briófitas chilenas (musgos, hepáticas y antocerotas), de los metabolitos secundarios de estas plantas y de la actividad biológica de extractos obtenidos a partir de especies de poblaciones chilenas. Nuestro objetivo es determinar el potencial de estas plantas como fuente de moléculas útiles para las industrias farmacéutica y agroalimentaria, y promover su conservación. Sólo de un 3,7% de las briófitas chilenas (55 spp.) han sido analizados químicamente sus extractos (metanol, éter, etanol, diclorometano, acetona y hexano). Se ha evaluado la actividad biológica sólo de cuatro especies de poblaciones chileno-argentinas (Porella chilensis (Lehm. & Lindenb.) Trevi., Riccardia polyclada (Mitt. ex Thurn) Hässel, Balantiopsis cancellata (Nees) Stephani, y Sphagnum magellanicum Brid.). La mayor parte de los estudios se ha concentrado en hepáticas de amplia distribución en el Hemisferio Austral y en los bosques templados de Chile y Argentina. Se discuten brevemente aspectos relacionados a la bioprospección como herramienta para la conservación, y al cultivo in vitro de briófitas con fines productivos y de conservación. PALABRAS CLAVE:Musgos, hepáticas, antocerotas, usos, metabolitos secundarios, actividad biológica, cultivo in vitro.

show abstract

Sesquiterpenoids, hopanoids and bis(bibenzyls) from the Argentine liverwort Plagiochasma rupestre

Cited by 31 publications

References 16 publications

Terpenoids and bisbibenzyls from Chinese liverwortsConocephalumconicumandDumortierahirsuta

Terpenoids and bisbibenzyls from Chinese liverwortsConocephalumconicumandDumortierahirsuta

Syntheses of Macrocyclic Bis(bibenzyl) Compounds Derived from Perrottetin E

Bioprospecting: A Tool to Conserve Chilean Bryophytes

Contact Info

Product

Resources

About