Setting reaction of α-TCP spheres and an acidic calcium phosphate solution for the fabrication of fully interconnected macroporous calcium phosphate

Kiên, Phạm Trung; Ishikawa, Kunio; Tsuru, Kanji

doi:10.1016/j.ceramint.2015.07.146

Cited by 24 publications

(9 citation statements)

References 20 publications

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“…The setting mechanism of b-TCP GC is comparable to that of DCPD forming cement, a-TCP spheres cement or a-TCP foam granules cement. 7,14,15 When b-TCP granules are mixed with an acidic solution, they dissolve and supply Ca 21 and PO 4 3-…”

Section: Discussionmentioning

confidence: 99%

“…Recently, Kien et al reported that alpha-tricalcium phosphate [a-TCP: a-Ca 3 (PO 4 ) 2 ] spheres can be set when exposed to an acidic calcium phosphate solution (referred to hereafter as an acidic solution for simplicity). 15 It was found that DCPD crystals were found on the surface of a-TCP spheres, and the formed DCPD crystals bridged the a-TCP spheres one another, and formed interconnected porous structure. Kien et al chose a-TCP spheres instead of a-TCP granules to understand fundamental mechanism of the setting reaction even though fabrication of a-TCP spheres by grinding is not practical for clinical use.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, Kien et al reported that alpha‐tricalcium phosphate [α‐TCP: α‐ Ca 3 (PO 4 ) 2 ] spheres can be set when exposed to an acidic calcium phosphate solution (referred to hereafter as an acidic solution for simplicity) . It was found that DCPD crystals were found on the surface of α‐TCP spheres, and the formed DCPD crystals bridged the α‐TCP spheres one another, and formed interconnected porous structure.…”

Section: Introductionmentioning

confidence: 99%

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Fabrication of self‐setting β‐tricalcium phosphate granular cement

et al. 2017

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Bone defect reconstruction would be greatly improved if β-tricalcium phosphate (β-TCP) granules had the ability to self-set without sacrificing their osteoconductivity potential. This study aimed to identify a method to permit β-TCP self-setting whilst maintaining good osteoconductivity. When mixed with acidic calcium phosphate solution, β-TCP granules were found to readily set, forming a fully interconnected porous structure. On mixing, dicalcium phosphate dihydrate crystals formed on the surface of β-TCP granules, bridging the granules and resulting in the setting reaction. The setting time of the β-TCP granular cement (β-TCP GC) was approximately 1 min and its mechanical strength, in terms of diametral tensile strength, was approximately 0.8 MPa. The β-TCP GC and β-TCP granules both showed the same level of osteoconductivity within rat calvaria bone defects. At 2 and 4 weeks post-implantation, new bone formation was comparable between the two β-TCP based bone substitutes. We conclude that β-TCP GC has excellent potential for use as a cement in bone defect reconstruction. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 800-807, 2018.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Fabrication of self‐setting β‐tricalcium phosphate granular cement

et al. 2017

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“…13,[19][20][21][22][23][24] We previously reported that a-tricalcium phosphate [a-TCP: a-Ca 3 (PO 4 ) 2 ] spheres and granules set to form an interconnected porous structure when exposed to acidic calcium phosphate solution. 25,26 The setting reaction of the a-TCP granules was based on a dissolution-precipitation reaction. First, a-TCP granules dissolve into the acidic calcium phosphate solution, supplying Ca 21 (1)…”

Section: Introductionmentioning

confidence: 99%

Fabrication of interconnected porous calcite by bridging calcite granules with dicalcium phosphate dihydrate and their histological evaluation

Ishikawa

Koga

Tsuru

et al. 2015

J Biomedical Materials Res

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Interconnected porous calcite has attracted attention as an artificial bone replacement material and as a precursor for the fabrication of carbonate apatite, which is also an artificial bone replacement material. In this study, calcite granules were exposed to acidic calcium phosphate solution, and the feasibility of fabricating interconnected porous calcite using this process was evaluated. No setting reaction was observed under the nonloading condition. In contrast, under loading conditions, calcite granules were bridged with dicalcium phosphate dihydrate crystals, and the calcite granules set into interconnected porous calcite foam. When applied 0.4 MPa of loading pressure during sample preparation, compressive strength of the obtained interconnected porous calcite was ∼1.5 MPa. The exposure of the calcite granules to acidic calcium phosphate solution under loading conditions was the key for the setting reaction to occur. This is because calcite granules cannot contact one another under the nonloading condition because of bubble formation on the surfaces of the calcite granules. The interconnected porous calcite revealed excellent tissue response, and new bone was able to penetrate into the porous calcite 2 weeks after implantation. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A 104A: 652-658, 2016.

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“…Based on this nature, Kien et al and Arifta et al fabricated calcium phosphate sphere-based scaffolds with interconnected macropores, employing the setting reaction of a-tricalcium phosphate spheres at 37 or 100°C, however, by this method the bonding strength between spheres was limited, and the scaffolds could not have considerable mechanical strength. 18,19 The bioceramic sphere-based scaffolds prepared by sintering the randomly packed spheres are rarely reported. It is shared that ceramics have a unique and high melting temperature.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of β‐tricalcium phosphate composite ceramic scaffolds based on spheres prepared by extrusion‐spheronization

Tian

Fang

et al. 2018

J Am Ceram Soc

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In this study, β‐tricalcium phosphate/phosphate‐based glass (β‐TCP/PG) composite spheres were prepared by an extrusion‐spheronization method featuring high production and fine control of sphere size. Subsequently, fully interconnected β‐TCP composite ceramic sphere‐based (TCCS) scaffolds were fabricated by sintering the randomly packed β‐TCP/PG composite spheres. The results manifested that at least 20% microcrystalline cellulose (MCC) was required to obtain β‐TCP/PG composite spheres in good spherical shape. The prepared TCCS scaffolds showed hierarchical pore architecture, which consisted of interconnected macropores among the spheres, a hollow core in the sphere, plentiful medium‐sized pores in the sphere shell and micropores among the grains. The pore architecture and mechanical strength of the TCCS scaffolds could be tailored by adjusting the sintering temperature, sphere size, and amounts of PG and MCC in the β‐TCP/PG composite spheres. This work is believed to open up new paths for the design and fabrication of interconnected bioceramic scaffolds for application in bone regeneration.

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Setting reaction of α-TCP spheres and an acidic calcium phosphate solution for the fabrication of fully interconnected macroporous calcium phosphate

Cited by 24 publications

References 20 publications

Fabrication of self‐setting β‐tricalcium phosphate granular cement

Fabrication of self‐setting β‐tricalcium phosphate granular cement

Fabrication of interconnected porous calcite by bridging calcite granules with dicalcium phosphate dihydrate and their histological evaluation

Fabrication of β‐tricalcium phosphate composite ceramic scaffolds based on spheres prepared by extrusion‐spheronization

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