Seven Japanese Herbals Prolonged Cardiac Allograft Survival

Yin, Enzhi; Jin, Xiangyuan; Uchiyama, Masateru; Zhang, Q.; Yanagisawa, T.; Inoue, Ayano; Guo, Yuanfa; Hara, Masanori; Matsuyama, Shigefumi; Imazuru, Tomohiro; Kawamura, Masafumi; Niimi, Masanori

doi:10.1016/j.transproceed.2018.04.015

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…The book Shang Han Lun stipulates that the Guizhi Gancao Decoction is frequently used in classical prescriptions. It consists of two herbal medicines (Ramulus Cinnamomi and GRER) used to treat inflammatory and ischaemic diseases (Ming Liu et al, 2017; Yin et al, 2018; Zhao et al, 2018). Cinnamic acid, liquiritin, isoliquiritigenin, and glycyrrhetinic acid are active components involved in improving the circulatory system and preventing arrhythmia (Gu et al, 2020; F. Song et al, 2013; Wegener & Nawrath, 1997; H.‐J.…”

Section: Novel Indications and Relevant Mechanisms Of Glycyrrhizae Ra...mentioning

confidence: 99%

Glycyrrhizae Radix et Rhizoma: The popular occurrence of herbal medicine applied in classical prescriptions

Kang

Zhang

et al. 2023

Phytotherapy Research

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Glycyrrhizae Radix et Rhizoma is a well-known herbal medicine with a wide range of pharmacological functions that has been used throughout Chinese history. This review presents a comprehensive introduction to this herb and its classical prescriptions. The article discusses the resources and distribution of species, methods of authentication and determination chemical composition, quality control of the original plants and herbal medicines, dosages use, common classical prescriptions, indications, and relevant mechanisms of the active content. Pharmacokinetic parameters, toxicity tests, clinical trials, and patent applications are discussed. The review will provide a good starting point for the research and development of classical prescriptions to develop herbal medicines for clinical use.

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Section: Novel Indications and Relevant Mechanisms Of Glycyrrhizae Ra...mentioning

confidence: 99%

Glycyrrhizae Radix et Rhizoma: The popular occurrence of herbal medicine applied in classical prescriptions

Kang

Zhang

et al. 2023

Phytotherapy Research

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Efficacy and safety of the traditional herbal medication Chai-Ling-Tang (in China), Siryung-tang (in Republic of Korea) or Sairei-To (in Japan)

Bailly

2024

Journal of Ethnopharmacology

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The Guizhi Gancao Decoction Attenuates Myocardial Ischemia-Reperfusion Injury by Suppressing Inflammation and Cardiomyocyte Apoptosis

Gao

Song

Cao

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Guizhi Gancao Decoction (GGD) is a well-known traditional Chinese herbal medicine for the treatment of various cardiovascular diseases, such as myocardial ischemia-reperfusion (I/R) injury and arrhythmia. However, the mechanism by which GGD contributes to the amelioration of cardiac injury remains unclear. The aim of this study was to investigate the potential protective role of GGD against myocardial I/R injury and its possible mechanism. Consistent with the effect of the positive drug (Trimetazidine, TMZ), we subsequently validated that GGD could ameliorate myocardial I/R injury as evidenced by histopathological examination and triphenyltetrazolium chloride (TTC) staining. Moreover, terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay demonstrated that GGD suppressed myocardial apoptosis, which may be related to the upregulation of Bcl-2, PPARα, and PPARγ and downregulation of Bax, caspase-3, and caspase-9. Pretreatment with GGD attenuated the levels of proinflammatory cytokines including tumor necrosis factor-α (TNF-α), interleukin- (IL-) 6, and IL-1β in serum by inhibiting Toll-like receptor 4 (TLR4)/NF-κB signaling pathway. These results indicated that GGD exhibits cardioprotective effects on myocardial I/R injury through inhibition of the TLR4/NF-κB signaling pathway, which led to reduced inflammatory response and the subsequent cardiomyocyte apoptosis.

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Seven Japanese Herbals Prolonged Cardiac Allograft Survival

Cited by 3 publications

References 14 publications

Glycyrrhizae Radix et Rhizoma: The popular occurrence of herbal medicine applied in classical prescriptions

Glycyrrhizae Radix et Rhizoma: The popular occurrence of herbal medicine applied in classical prescriptions

Efficacy and safety of the traditional herbal medication Chai-Ling-Tang (in China), Siryung-tang (in Republic of Korea) or Sairei-To (in Japan)

The Guizhi Gancao Decoction Attenuates Myocardial Ischemia-Reperfusion Injury by Suppressing Inflammation and Cardiomyocyte Apoptosis

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