Seven new cytotoxic phenylspirodrimane derivatives from the endophytic fungus <i>Stachybotrys chartarum</i>

Zhang, Hong; Yang, Ming‐Hua; Zhuo, Fang-fang; Gao, Na; Cheng, Xiao-Bei; Wang, Xiao-Bing; Pei, Yue‐Hu; Kong, Ling–Yi

doi:10.1039/c8ra10195g

Cited by 20 publications

(15 citation statements)

References 29 publications

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“…It was found that 51 and 105 – 108 had cytotoxic potential versus U-2OS and MDA-MB-231 (IC 50 s 4.5–21.7 µM). Besides, 51 and 107 demonstrated powerful anti-proliferation and anti-apoptosis effectiveness versus U-2OS cells, while all metabolites had no influence (IC 50 >50 µM) versus MCF-7 cells [ 70 ]. These data may provide evidence for further research into the anticancer activities of these compounds.…”

Section: Secondary Metabolites From S Chartarummentioning

confidence: 99%

Stachybotrys chartarum—A Hidden Treasure: Secondary Metabolites, Bioactivities, and Biotechnological Relevance

Ibrahim

Choudhry

Asseri

et al. 2022

JoF

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Fungi are renowned as a fountainhead of bio-metabolites that could be employed for producing novel therapeutic agents, as well as enzymes with wide biotechnological and industrial applications. Stachybotrys chartarum (black mold) (Stachybotriaceae) is a toxigenic fungus that is commonly found in damp environments. This fungus has the capacity to produce various classes of bio-metabolites with unrivaled structural features, including cyclosporins, cochlioquinones, atranones, trichothecenes, dolabellanes, phenylspirodrimanes, xanthones, and isoindoline and chromene derivatives. Moreover, it is a source of various enzymes that could have variable biotechnological and industrial relevance. The current review highlights the formerly published data on S. chartarum, including its metabolites and their bioactivities, as well as industrial and biotechnological relevance dated from 1973 to the beginning of 2022. In this work, 215 metabolites have been listed and 138 references have been cited.

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Section: Secondary Metabolites From S Chartarummentioning

confidence: 99%

Stachybotrys chartarum—A Hidden Treasure: Secondary Metabolites, Bioactivities, and Biotechnological Relevance

Ibrahim

Choudhry

Asseri

et al. 2022

JoF

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“…In addition, Stachybotrys has been detected on damp paper, cotton, linen, cellulose-based building materials (drywalls, wallpapers in indoor environments), water-damaged indoor buildings, and air ducts [ 5 , 17 , 19 , 28 , 31 , 32 , 33 , 34 , 35 ]. Most Stachybotrys species are cellulolytic saprobes [ 36 ], as well as plant pathogens [ 37 , 38 ] and endophytes [ 39 , 40 , 41 , 42 , 43 ]. Memnoniella species exhibit saprobic lifestyles and have been reported from dead plant materials and soil [ 20 , 39 ].…”

Section: Introductionmentioning

confidence: 99%

“…Most Stachybotrys species are cellulolytic saprobes [ 36 ], as well as plant pathogens [ 37 , 38 ] and endophytes [ 39 , 40 , 41 , 42 , 43 ]. Memnoniella species exhibit saprobic lifestyles and have been reported from dead plant materials and soil [ 20 , 39 ]. Some taxa of Memnoniella and Stachybotrys ( M. echinata and S. chartarum ) coexist in similar ecological habitats such as indoor environments [ 39 ].…”

Section: Introductionmentioning

confidence: 99%

“…Memnoniella species exhibit saprobic lifestyles and have been reported from dead plant materials and soil [ 20 , 39 ]. Some taxa of Memnoniella and Stachybotrys ( M. echinata and S. chartarum ) coexist in similar ecological habitats such as indoor environments [ 39 ]. Mainly, S. chartarum and a few other species of Stachybotrys (i.e., S. elegans and S. microsporus ) have veterinary and medical importance as they produce several mycotoxins [ 44 , 45 , 46 , 47 , 48 ].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, S. nielamuensis [ 50 ] (Tibet), S. subcylindrosporus [ 33 ] (Hainan), S. variabilis [ 51 ] (Qinghai), S. yunnanensis [ 52 ] (Yunnan), and S. zhangmuensis [ 50 ] (Tibet) were described from China. Memnoniella chromolaenae , M. echinata and M. sinensis were reported from Yunnan Province, China and Thailand [ 24 , 39 , 53 ].…”

Section: Introductionmentioning

confidence: 99%

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Stachybotrys musae sp. nov., S. microsporus, and Memnoniella levispora (Stachybotryaceae, Hypocreales) Found on Bananas in China and Thailand

Samarakoon

Wanasinghe

Phookamsak

et al. 2021

Life

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A study was conducted to investigate saprobic fungal niches of Stachybotryaceae (Hypocreales) associated with leaves of Musa (banana) in China and Thailand. Three hyphomycetous taxa were collected during the dry season of 2018 and 2019. After a careful phenotypic characterization (both macro- and microscopically) and a phylogenetic tree reconstruction using a concatenated sequence dataset of internal transcribed spacer (ITS), calmodulin (cmdA), RNA polymerase II second largest subunit (rpb2), β-tubulin (tub2), and the translation elongation factor 1-alpha (tef1) gene regions, we report three species of Stachybotryaceae. Stachybotrys musae is introduced as a novel taxon from Yunnan, China, while S.microsporus is reported from Chiang Rai Province in Thailand on Musa. In addition, Memnoniella levispora is also reported from China for the first time.

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Chartarlactams Q−T, Dimeric Phenylspirodrimanes with Antibacterial and Antiviral Activities

Liu

Guo

et al. 2020

Chemistry & Biodiversity

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Four new phenylspirodrimane‐type dimers, namely chartarlactams Q−T, along with stachyin B were isolated from the fermentation broth of a sponge‐derived fungus Stachybotrys chartarum WGC‐25 C‐6. Chartarlactams Q−T were structurally featured by the dimerization of two units of phenylspirodrimane linked by a C−N bond. Their structures were determined on the basis of extensive spectroscopic analysis, while quantum ECD calculation and modified Mosher's method were used for the assignment of absolute configurations. Chartarlactams Q−S and stachyin B showed moderate inhibition against bacterial pathogen Staphylococcus aureus with MIC values ranging from 4 μg/mL to 16 μg/mL, and chartarlactam T exhibited significant inhibition toward ZIKV virus.

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Seven new cytotoxic phenylspirodrimane derivatives from the endophytic fungus Stachybotrys chartarum

Abstract: The diverse structures and anticancer activities of phenylspirodrimane derivatives are investigated.

Cited by 20 publications

References 29 publications

Stachybotrys chartarum—A Hidden Treasure: Secondary Metabolites, Bioactivities, and Biotechnological Relevance

Stachybotrys chartarum—A Hidden Treasure: Secondary Metabolites, Bioactivities, and Biotechnological Relevance

Stachybotrys musae sp. nov., S. microsporus, and Memnoniella levispora (Stachybotryaceae, Hypocreales) Found on Bananas in China and Thailand

Chartarlactams Q−T, Dimeric Phenylspirodrimanes with Antibacterial and Antiviral Activities

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