Several roles of CCKA and CCKB receptor subtypes in CCK-8-induced and LiCl-induced taste aversion conditioning

Mosher, Jack T.; Johnson, Michael F.; Birkemo, Lawrence; Ervin, Gregory N.

doi:10.1016/0196-9781(96)00028-9

Cited by 13 publications

(2 citation statements)

References 28 publications

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“…The CTA effects after administration of CCK 8 are completely blocked by the CCK 1 ‐receptor antagonist MK‐329 and only partially blocked by the CCK 2 ‐receptor antagonist L‐365.260 ( Mosher et al ., 1996 ). The partial antagonistic effect of L‐365.260 was ascribed to an anxiolytic effect of the antagonist, as it is also able to partially antagonize LiCl‐induced CTA.…”

Section: Discussionmentioning

confidence: 99%

PEGylated cholecystokinin is more potent in inducing anorexia than conditioned taste aversion in rats

Verbaeys

León-Tamaríz

Pottel

et al. 2008

British J Pharmacology

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Background and purpose: The physiological involvement of endogenous cholecystokinin (CCK) in the termination of feeding has been challenged by evidence of aversive effects of exogenous CCK 8 . We previously prolonged the anorectic effect of CCK by conjugation to polyethylene glycol (PEGylation) to produce PEG-CCK 9 . In this study, we investigated the ability of different doses of PEG-CCK 9 to induce conditioned taste aversion (CTA) and satiety and identified the receptors involved in CTA induction. Experimental approach: Induction of CTA, measured by the saccharin preference ratio determined in a two-bottle CTA procedure, and of satiety in adult male Wistar rats after intraperitoneal (i.p.) injection of different doses of PEG-CCK 9 (1, 2, 4, 8, 16 or 32 mg kg À1 ) was compared. Devazepide (100 mg kg À1 ) and 2-NAP (3 mg kg À1 ), two selective CCK 1 -receptor antagonists, were co-administered i.p. with PEG-CCK 9 (8 mg kg À1 ) and the CTA effects monitored. Key results: PEG-CCK 9 dose-dependently induced CTA, with a minimal effective dose of 8 mg kg À1 , whereas the minimal effective dose to induce satiety was 1 mg kg À1 . The CTA effects of PEG-CCK 9 were completely abolished by i.p. administration of devazepide prior to PEG-CCK 9 treatment and only partially abolished by administration of 2-NAP. Conclusions and implications: Although PEG-CCK 9 -induced satiety and PEG-CCK 9 -induced CTA both increased with dose, the conjugate was more potent in inducing satiety, suggesting that the anorexia could not be completely attributed to the aversiveness of the drug. As observed with induction of satiety, PEG-CCK 9 -induced CTA was mediated by CCK 1 -receptors.

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Section: Discussionmentioning

confidence: 99%

PEGylated cholecystokinin is more potent in inducing anorexia than conditioned taste aversion in rats

Verbaeys

León-Tamaríz

Pottel

et al. 2008

British J Pharmacology

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“…The effect of CCK receptor blockade on acquisition of this preference was assessed in Experiment 3. Since gastric distension may activate CCK release and ensuing stimulation ofCCK A receptors, and since stimulation of these receptors has aversive consequences (Mosher, Birkemo, Johnson, & Ervin, 1998;Mosher, Johnson, Birkemo, & Ervin, 1996), we hypothesized that a CCK A antagonist would enhance place preference.…”

Section: Methodsmentioning

confidence: 99%

The importance of the stomach for conditioned place preference produced by drinking sucrose in rats

Arnould

Ågmo

1999

Psychobiology

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Sucrose produces conditioned place preference when the sweetener is delivered immediately before confmement in the place preference box. To evaluate the role of the oral and gastric effects of sucrose, rats were allowed to drink sucrose or were given sucrose or water intragastrically by gavage. The rats developed a preference in all cases in which the reinforcing event was delivered 3 min 30 sec before confmement, but not when an interval of 15 min was used. Contiguity between reinforcing event and conditioning is of importance. In an additional experiment, we tried to replicate the effect obtained with plain water and evaluated the role of cholecystokinin (CCK) receptors. Before water administration, the rats were subcutaneously injected with saline, devazepide (0.01 mg/kg) , or L-365,260 (0.01 mg/kg). Only the group treated with devazepide showed significant place preference. CCK A receptor blockade seems to enhance the reward value of gastric distension, and distension alone appears to be an unreliable reinforcing event.Ingestive behaviors are associated with a multitude of physiological reactions. The sight and smell of food activate digestive processes that anticipate the arrival of food in the gut (Brand, Cagan, & Nairn, 1982). These responses are further reinforced by taste stimuli and by the activation of mechanoreceptors in the esophagus and, eventually, in the stomach (Fantino, 1984). Food is then digested and absorbed, producing several modifications in the composition of blood. One of these changes is an increase in the concentration of cholecystokinin (CCK;

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Psychotropic and neurotropic activity1

Vogel¹,

Vogel²,

Schölkens³

et al. 2002

Drug Discovery and Evaluation

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Several roles of CCKA and CCKB receptor subtypes in CCK-8-induced and LiCl-induced taste aversion conditioning

Cited by 13 publications

References 28 publications

PEGylated cholecystokinin is more potent in inducing anorexia than conditioned taste aversion in rats

PEGylated cholecystokinin is more potent in inducing anorexia than conditioned taste aversion in rats

The importance of the stomach for conditioned place preference produced by drinking sucrose in rats

Psychotropic and neurotropic activity1

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