Severe Acute Respiratory Syndrome: Radiographic Appearances and Pattern of Progression in 138 Patients

Wong, Kin Fai Ellick; Antonio, Gregory E.; Hui, David S.; Lee, Nelson; Yuen, Edmund H.Y.; Wu, Alan; Leung, Chi Bon; Rainer, Timothy Hudson; Cameron, Peter; Chung, Sydney S.C.; Sung, Joseph J.Y.; Ahuja, Anil T.

doi:10.1148/radiol.2282030593

Cited by 276 publications

(254 citation statements)

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“…There was no significant correlation between the FVC, FEV1, FEV1/FVC ratio, TL,CO and the worst CXR score [16], as well as the serum lactic dehydrogenase level, during the acute illness. Neither was there any significant correlation between these pulmonary function data and the administration of steroid or ribavarine during the acute phase of the illness.…”

Section: Cases Of Sars (N=206)mentioning

confidence: 70%

“…A total of 23 of the 46 patients (50%) were healthcare workers. The mean ¡ SD of the percentage of lung involvement based on the worst CXR appearance during the acute illness, using a scoring system similar to that of WONG et al [16], was 40.6 ¡ 29.9%. In total, 10 patients (22%) required admission to the intensive care unit (ICU) and the mean arterial oxygen tension (Pa,O 2 )/inspiratory oxygen fraction (FI,O 2 ) ratio among these patients in the ICU was 95.5 ¡ 65.6.…”

Section: Resultsmentioning

confidence: 96%

“…Classifying impairment of measured exercise capacity [7], 10 patients (23%) had a V9O 2 ,max o25 mL?kg . None of the patients had ventilatory limitation of exercise as defined by all three of the following criteria: 1) a ratio of the V9E at peak exercise (V9E,max) to the maximal voluntary ventilation (MVV; calculated as FEV1645.12-15.85 [16]) w0.8; 2) MVV-V9E,max v12 L?min -1 ; and 3) maximum HR v90% pred. In four patients, the breathing reserve was low and the first two of the previous criteria were achieved.…”

Section: Cases Of Sars (N=206)mentioning

confidence: 99%

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Pulmonary function and exercise capacity in survivors of severe acute respiratory syndrome

Kc¹

2004

Eur Respir J

148

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The aim of this study was to investigate pulmonary function and exercise capacity in a group of survivors of the severe acute respiratory syndrome (SARS).At 3 months after hospital discharge, 46 survivors of SARS underwent the following evaluation: spirometry, static lung volumes and carbon monoxide transfer factor (TL,CO). In total, 44 of these patients underwent cardiopulmonary exercise testing.No abnormalities were detected in the pulmonary function tests in 23 (50%) of the patients. Abnormalities of forced vital capacity (FVC), forced expiratory volume in one second (FEV1), FEV1/FVC and TL,CO were detected in seven (15%), 12 (26%), one (2%) and 18 (39%) patients, respectively. All of these abnormalities were mild except in one case. In 18 patients (41%), the maximum aerobic capacity was below the lower limit of the normal range. Breathing reserve was low in four patients and significant oxygen desaturation was detected in a further four patients. Comparison of the measured exercise capacity with resting pulmonary function tests showed many cases of discordance in impairment.In conclusion, pulmonary function defects were detected in half of the recovered severe acute respiratory syndrome patients 3 months after hospital discharge, but the impairment was mild in almost all cases. Many patients had reduced exercise capacity that cannot be accounted for by impairment of pulmonary function.

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Section: Cases Of Sars (N=206)mentioning

confidence: 70%

Section: Resultsmentioning

confidence: 96%

Section: Cases Of Sars (N=206)mentioning

confidence: 99%

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Pulmonary function and exercise capacity in survivors of severe acute respiratory syndrome

Kc¹

2004

Eur Respir J

148

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“…4 Nuestro trabajo intenta aportar elementos para establecer el riesgo de evolución adversa en pacientes pediátricos con infección respiratoria por H1N1 al ingreso de su hospitalización; la identificación de patrones radiológicos podría ser de utilidad para predecir la evolución clínica y, eventualmente, ser empleada como herramienta para la toma de conductas médicas. Según nuestros hallazgos, los patrones de vidrio esmerilado y condensación al ingreso en pacientes con influenza A H1N1 se correlacionan con una evolución clínica más desfavorable.…”

Section: Discussionunclassified

Infección respiratoria por influenza A H1N1 en niños: Hallazgos radiológicos y correlación con el pronóstico clínico en pacientes internados en un hospital pediátrico

et al. 2011

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Arch Argent Pediatr 2011;109(6):525-529 / 525 RESUMEN Introducción. En 2009, la OMS declaró a la infección por el virus Influenza A H1N1 como pandemia mundial. Se ha comunicado que el patrón radiológico podría predecir la evolución clínica en pacientes afectados. Objetivo. Describir los hallazgos radiológicos en las radiografías de tórax (Rx) de frente, obtenidas al ingreso institucional, en pacientes pediátricos internados con infección respiratoria por Influenza A H1N1 y su correlación con la evolución clínica. Población y métodos. Estudio retrospectivo, observacional y descriptivo de la historia clínica y la Rx de frente al ingreso en 47 pacientes con diagnóstico de infección respiratoria por Influenza A H1N1. Resultados. La Rx fue patológica en el 94% de los pacientes. El patrón de condensación fue más frecuente en pacientes que requirieron mayor cantidad de días de oxígeno y mayor riesgo de internación en unidad de cuidados intensivos. El patrón en vidrio esmerilado se asoció también con mayor cantidad de días de oxígeno suplementario. Conclusiones. Las Rx presentaron patrones predominantes en vidrio esmerilado y refuerzo peribronquial. Los niños con hallazgos radiológicos de condensación lobular y vidrio esmerilado al ingreso presentaron una evolución clínica más grave. Palabras clave: virus Influenza A H1N1, radiografía tórax, niños.

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“…have abnormal chest radiographs, all of which show airspace consolidation that initially tends to be peripheral and lower zone in distribution [29][30][31]. Whilst most patients have abnormal chest radiograph on presentation, the patterns are usually no cavitation, hilar lymphadenopathy or pleural effusion at presentation [32].…”

Section: Bedside and Clinical Diagnosis Of Severe Acute Respiratory Smentioning

confidence: 99%

Diagnosis and pharmacotherapy of severe acute respiratory syndrome: what have we learnt?

Tsang¹

2004

Eur Respir J

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In 2003, the onset of severe acute respiratory syndrome (SARS) caused worldwide chaos. Although SARS was eradicated by isolation towards the end of 2003, sporadic cases have been reported in Singapore, Taiwan and mainland China.In this review, SARS is discussed as a disease, as well as its diagnosis, management and pharmacotherapy.Respiratory physicians and healthcare professionals have to be aware of advances in the understanding of the diagnosis and management of severe acute respiratory syndrome. More research is required in order to prepare for if this respiratory infection recurs, but there are concerns that adequate pharmaceutical support may be lacking for the development of a vaccine.

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Severe Acute Respiratory Syndrome: Radiographic Appearances and Pattern of Progression in 138 Patients

Abstract: Predominant peripheral location; common progression pattern from unilateral focal air-space opacity to unilateral multifocal or bilateral involvement during treatment; and lack of cavitation, lymphadenopathy, and pleural effusion are the more distinctive radiographic findings of SARS.

Cited by 276 publications

References 4 publications

Pulmonary function and exercise capacity in survivors of severe acute respiratory syndrome

Pulmonary function and exercise capacity in survivors of severe acute respiratory syndrome

Infección respiratoria por influenza A H1N1 en niños: Hallazgos radiológicos y correlación con el pronóstico clínico en pacientes internados en un hospital pediátrico

Diagnosis and pharmacotherapy of severe acute respiratory syndrome: what have we learnt?

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