Severe allergic reaction to human insulin in the patient with diabetic ketoacidosis

Oray, Neşe Çolak; Bayram, Başak; Altıntaş, Emel; Sivrikaya, Semra; Savran, Yusuf

doi:10.1016/j.tjem.2017.07.004

Cited by 4 publications

(2 citation statements)

References 7 publications

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“…Severe allergic reactions may be treated with combinations of antihistamines in addition to epinephrine and systemic steroids. The ultimate goal is switching to a different insulin formulation and generating a proper medication regimen to appropriately maintain blood glucose levels within the normal range [16].…”

Section: Discussionmentioning

confidence: 99%

New-Onset Insulin Allergy After COVID-19 Infection in an Insulin-Dependent Type-2 Diabetic Patient: A Rare Complication

Qureshi

Naeem²,

Tariq³

et al. 2021

Cureus

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Coronavirus disease 2019 (COVID-19) is an infectious respiratory disease caused by the novel coronavirus severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Initially, it was reported in December 2019 and became a global pandemic in March 2020, with many presentations and after-effects. We report the case of a 68-year-old female patient who presented to the emergency room with the chief complaint of a skin rash and itching all over her body, developing within a few minutes of insulin injection. The patient had tested positive for COVID-19 almost eight days ago and was self-quarantined. She was a known diabetic for the past 28 years. Her blood glucose levels were maintained within the normal range by a combination regimen of oral anti-diabetic drugs and subcutaneous humulin 70/30 (70% neutral protamine Hagedorn (NPH) insulin and 30% regular human insulin) injections. After careful examination and thorough history taking, a newly acquired insulin allergy was diagnosed in the patient, attributed to her disrupted immune system due to the recent COVID-19 infection.

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Section: Discussionmentioning

confidence: 99%

New-Onset Insulin Allergy After COVID-19 Infection in an Insulin-Dependent Type-2 Diabetic Patient: A Rare Complication

Qureshi

Naeem²,

Tariq³

et al. 2021

Cureus

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“…The basic mechanism driving this is insulin insufficiency. Insulin doses were disregarded because insulin was not available or available to low-income individuals in rural regions [6][7]. The knowledge among low-income individuals found to be below level and responsible for hospital admissions in all patients who are diabetes and established DKA.…”

Section: Introductionmentioning

confidence: 99%

Requirement of Intravenous Fluid and Insulin in the Management of Diabetic Ketoacidosis to Overcome the Crisis

Qasim¹,

Hashir²,

Batool³

et al. 2021

PJMHS

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Objective: The aim of this study is to determine the requirement of intravenous fluid and insulin in the treatment of diabetic ketoacidosis to overcome the crisis. Study Design: Cross-sectional Place and Duration:Study was conducted at Medicine department of King Abdullah Teaching Hospital Mansehra and Nishtar Medical University Hospital Multan for six months duration from15thDecember, 2020 to 15thJune, 2020. Methods: Total seventy patients of both genders were presented in this study. Patients were aged between 18-65 years. Patients details demographics age, sex and body mass index were recorded after taking written consent. Patients had diabetic ketoacidosis were presented in this study. Frequency of intravenous fluid and insulin were assessed to overcome the crisis of diabetic ketoacidosis by using portland protocol. Complete data was analyzed by SPSS 22.0 version. Results: Mean age of the patients was 30.51±7.41 years with mean BMI 25.18±3.48 kg/m2. 38(54.3%) cases were females and 32 (45.7%) patients were males. 42 (60%) cases had previous history of diabetes and the rest28 (40%) were newly diagnosed.Prevalence of DKA was more common in low socio-economic status found in 39 (55.7%) cases. Vomiting was the most common symptom found in 35 (50%) cases, followed by infection of insulin doses 18 (25.7%) cases, abdominal pain found in 15 (21.43%) patients. 32 (45.7%) patients who had increased diuresis received 11L of fluid in the treatment of DKA, 91-100 units of insulin were given to 18 (25.71%) cases, and for management of acidosis 24 (34.3%) patients took 2-days. There was no any mortality found in this study. Conclusion:We concluded in this study that early diagnosed of diabetic ketoacidosis is necessary for treatment. Removal of adequate fluid was necessary to avoid mortality. Keywords:Intravenous fluid, Insulin, Diabetic ketoacidosis, Diabetes

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RSSDI consensus recommendations on insulin therapy in the management of diabetes

Chawla¹,

Makkar

Aggarwal

et al. 2019

Int J Diabetes Dev Ctries

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Severe allergic reaction to human insulin in the patient with diabetic ketoacidosis

Cited by 4 publications

References 7 publications

New-Onset Insulin Allergy After COVID-19 Infection in an Insulin-Dependent Type-2 Diabetic Patient: A Rare Complication

New-Onset Insulin Allergy After COVID-19 Infection in an Insulin-Dependent Type-2 Diabetic Patient: A Rare Complication

Requirement of Intravenous Fluid and Insulin in the Management of Diabetic Ketoacidosis to Overcome the Crisis

RSSDI consensus recommendations on insulin therapy in the management of diabetes

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