Severe allergic reaction to intravenous injection of glucagon.

Multicenter Phase Ii Randomized Study Evaluating Dose–response of Antiperistaltic Effect of L‐menthol Sprayed Onto the Gastric Mucosa for Upper Gastrointestinal Endoscopy

“…Antispasmodic agents such as hyoscine‐ N ‐butylbromide and glucagon are used to inhibit gastric peristalsis. However, these agents can cause adverse drug reactions, such as cardiovascular events, adverse effect of ocular, urinary and salivary systems, and anaphylactic shock with hyoscine‐ N ‐butylbromide and delayed hypoglycemia and anaphylactic reactions with glucagon 4–10 . Some of the adverse events of these antispasmodic agents are dose dependent 11 …”

“…However, these agents can cause adverse drug reactions, such as cardiovascular events, adverse effect of ocular, urinary and salivary systems, and anaphylactic shock with hyoscine-Nbutylbromide and delayed hypoglycemia and anaphylactic reactions with glucagon. [4][5][6][7][8][9][10] Some of the adverse events of these antispasmodic agents are dose dependent. 11 Upper GI endoscopy itself can also lead to cardiovascular complications such as arrhythmias, but is generally a safe procedure for the purpose of diagnosis.…”

Antiperistaltic effect and safety of l-menthol sprayed on the gastric mucosa for upper GI endoscopy: a phase III, multicenter, randomized, double-blind, placebo-controlled study

“…14 Glucagon can induce nausea and vomiting, as well as anaphylactic and allergic reactions. [15][16][17] Peppermint oil and L-menthol have been used since antiquity to treat a variety of conditions, including GI disorders. 18 These substances relax GI smooth muscle in vitro by blocking the entry of calcium ions into GI smooth muscle cells.…”

A Phase I Study Evaluating Tolerability, Pharmacokinetics, and Preliminary Efficacy of L-Menthol in Upper Gastrointestinal Endoscopy

“…Hyoscine‐ N ‐butylbromide can cause cardiovascular events; adverse effects on the ocular, urinary and salivary systems; and anaphylactic shock 5 , 6 , 7 , 8 , 9 . Glucagon, also administered as an antispasmodic, can cause delayed hypoglycemia and anaphylactic reactions 6 , 8 , 10 , 11 , 12…”