Severe Anemia in Papua New Guinean Children from a Malaria-Endemic Area: A Case-Control Etiologic Study

Manning, Laurens; Laman, Moses; Rosanas-Urgell, Anna; Michon, P; Aipit, Susan; Bona, Cathy; Siba, Peter; Müeller, Ivo; Davis, Timothy M. E.

doi:10.1371/journal.pntd.0001972

Cited by 42 publications

(47 citation statements)

References 49 publications

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“…Our results correlate with the data of other researchers who studied the PVI-associated malaria in children in malaria-endemic regions: among children under 5 years, the absolute majority of cases of PVI was accompanied by a complicated course of malaria [4,10,14].…”

Section: Discussionsupporting

confidence: 90%

Impact of Coinfection of Pv B19 on the Course and Prognosis of Malaria Caused by Plasmodium Falciparum

Николаевна

Khamitova

Slita

et al. 2018

Russian Journal of Infection and Immunity

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Parvovirus infection (PVI) is widespread in the world; more than 80% of the adult population have antibodies of IgG class to parvovirus B19. Malaria is a vector-borne parasitic disease caused by the protozoa of the genus Plasmodium, that is widespread in the countries of Africa, Southeast Asia, Oceania. The objective of the present study was to evaluate the effect of parvovirus B19 infection on the clinical course of malaria and the outcome of the underlying disease. During the period 2016–2018 blood plasma samples of 316 patients from the hospital of the Friya Prefecture of the Republic of Guinea (GR) with confirmed diagnosis of malaria were examined for the presence of PVB19 DNA. The clinical course of malaria in 316 examined patients was divided into group of either mild or complicated. In total, PVB19 DNA was detected in blood plasma in 55 of 316 patients (17.41±2.13%). But in the group with co-infection of PVB19 and P. falciparum complications were observed in 40 of 55 (72.73±2.75%) patients, and in 6 of 55 cases (10.91±4.40%) the disease resulted in death. In the group of patients with malaria without PVI, complications occurred in 99 of 261 patients (37.9±3.0%); of those 2 (0.77±0.54%) died. It was found that the most numerous group in the structure of malaria patients is represented by children under 5 (median 3) years (89, or 28.25±2.53%). Our results correlate with the data of other researchers who studied the PVI-associated malaria in children in malaria-endemic regions: among children under 5 years, the absolute majority of cases of PVI was accompanied by a complicated course of malaria. The primary parvovirus infection can aggravate the course of malaria, especially when combined with other unfavorable conditions (iron deficiency, malnutrition, helminthic infections, co-infections, etc.). Thus, infection with PVB19 becomes a critical factor, which can provoke a severe life-threatening anemia, and also cause other complications.

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Section: Discussionsupporting

confidence: 90%

Impact of Coinfection of Pv B19 on the Course and Prognosis of Malaria Caused by Plasmodium Falciparum

Николаевна

Khamitova

Slita

et al. 2018

Russian Journal of Infection and Immunity

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“…Anemia in malaria is multifactorial and mainly due to haemolysis and dyserythropoiesis [39]. Recently, two studies in children of Papua New Guinea showed that certain common infections, and especially B19V-infection can play a critical role in the etiology of severe anemia besides other factors, such as malnutrition and iron deficiency, in a highly endemic area for malaria [21,40]. This finding was further supported by yet another study showing that high B19V IgM levels were significantly associated with severe anemia in Kenyan children [20].…”

Section: Discussionmentioning

confidence: 99%

Co-infection of human parvovirus B19 with Plasmodium falciparum contributes to malaria disease severity in Gabonese patients

Toàn

Song

et al. 2013

BMC Infect Dis

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BackgroundHigh seroprevalence of parvovirus B19 (B19V) coinfection with Plasmodium falciparum has been previously reported. However, the impact of B19V-infection on the clinical course of malaria is still elusive. In this study, we investigated the prevalence and clinical significance of B19V co-infection in Gabonese children with malaria.MethodsB19V prevalence was analyzed in serum samples of 197 Gabonese children with P. falciparum malaria and 85 healthy controls using polymerase chain reaction (PCR), enzyme-linked immunosorbent assay (ELISA), and direct DNA-sequencing.ResultsB19V was detected in 29/282 (10.28%) of Gabonese children. B19V was observed more frequently in P. falciparum malaria patients (14.21%) in comparison to healthy individuals (1.17%) (P<0.001). Notably, the mild-malaria group revealed significantly lower hematocrit levels in B19V/P. falciparum co-infection than in P. falciparum mono-infection (P<0.05). Genetic analysis revealed a predominance of B19V genotype-1 (71.43%) in the studied population. However, B19V-genotype 2 was observed significantly more often in children with severe-malaria than in mild-malaria (P=0.04).ConclusionOur findings reveal that B19V-infection is frequent in Gabonese children with P. falciparum malaria and signifies a possible contribution of B19V on the clinical course of malaria in a genotype-dependent manner. B19V co-infection should be considered as a additional diagnostic measure in malaria patients with life threatening anemia.

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“…B19V infection and malaria. Of relevance to potential vaccine development, B19V occurs in areas where malaria is endemic (747), and serological surveys have suggested worse chronic anemia in children who are seropositive for B19V (IgG) or have evidence of recent infection (IgM and viral DNA) (748)(749)(750)(751). Acute B19V infection may occur concurrently with malaria (752,753).…”

Section: Clinical Manifestations Diseases Caused By B19v Infectionmentioning

confidence: 99%

Human Parvoviruses

2017

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Parvovirus B19 (B19V) and human bocavirus 1 (HBoV1), members of the large Parvoviridae family, are human pathogens responsible for a variety of diseases. For B19V in particular, host features determine disease manifestations. These viruses are prevalent worldwide and are culturable in vitro, and serological and molecular assays are available but require careful interpretation of results. Additional human parvoviruses, including HBoV2 to -4, human parvovirus 4 (PARV4), and human bufavirus (BuV) are also reviewed. The full spectrum of parvovirus disease in humans has yet to be established. Candidate recombinant B19V vaccines have been developed but may not be commercially feasible. We review relevant features of the molecular and cellular biology of these viruses, and the human immune response that they elicit, which have allowed a deep understanding of pathophysiology.

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Severe Anemia in Papua New Guinean Children from a Malaria-Endemic Area: A Case-Control Etiologic Study

Cited by 42 publications

References 49 publications

Impact of Coinfection of Pv B19 on the Course and Prognosis of Malaria Caused by Plasmodium Falciparum

Impact of Coinfection of Pv B19 on the Course and Prognosis of Malaria Caused by Plasmodium Falciparum

Co-infection of human parvovirus B19 with Plasmodium falciparum contributes to malaria disease severity in Gabonese patients

Human Parvoviruses

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