Severe bleeding diathesis in a premature baby with extensive hepatic necrosis due to portal vein thrombosis of prenatal onset

Ries, M.; Zenker, M.; Kandler, Christina; Rauch, Ralf; Fischer, Eva

doi:10.1007/s002770050526

Cited by 5 publications

(3 citation statements)

References 7 publications

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“…Hepatic necrosis has been described in newborns and has certain etiologies. The most commonly recognized etiologies include neonatal giant cell hepatitis (2, 3), asphyxia, hypovolemia and septicemia (4), circulatory failure because of congenital cardiac or great vessel anomalies (5), neonatal hemochromatosis (6), infantile hepatic hemangioendothelioma (7, 8), viral infections (9, 10) metabolic diseases (11–14), and portal vein thrombosis associated with systemic circulatory insufficiency (15). Although the pathological exam of the explanted liver showed an organized portal vein thrombus, this is believed to be a secondary process because of absence of any sign of ischemic damage within the hepatic lobules.…”

Section: Discussion and Literature Reviewmentioning

confidence: 99%

A reduced segment II/III graft for neonatal liver failure with absence of detectable hepatocytes. A case report and literature review

Alawi

Mitros

Bishop

et al. 2011

Pediatric Transplantation

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When hepatic failure occurs in newborns, most cases are because of viral hepatitis, metabolic diseases, and neonatal hemochromatosis. It is rare to have liver failure presenting in the first day after birth. We report a unique case of a newborn baby with liver failure in the first day of life who received a reduced segment II and III graft when she was 19 days old and became the youngest survivor of LDLT. Common and rare causes of liver failure in this age group were excluded by appropriate testing. She underwent a liver biopsy that showed a liver devoid of hepatocytes. Similar pathological findings were found in the explanted liver. She was discharged from the hospital with normal graft function three months after the transplant.

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Section: Discussion and Literature Reviewmentioning

confidence: 99%

A reduced segment II/III graft for neonatal liver failure with absence of detectable hepatocytes. A case report and literature review

Alawi

Mitros

Bishop

et al. 2011

Pediatric Transplantation

View full text Add to dashboard Cite

show abstract

“…In one report, PVT was discovered after birth in two children who presented with seizures secondary to a cerebral infarction consistent with an embolic event7. In the second report, PVT was discovered after birth in a neonate born at 29 weeks of gestation due to the development of hydrops secondary to acardiac twinning8. There was hepatic necrosis and liver failure.…”

Section: Discussionmentioning

confidence: 99%

“…Recent interest has focused on the risk of prothrombotic risk factors in neonatal venous thrombosis8–10. Heller et al looked at the incidence of prothrombotic risk factors in neonates with PVT5.…”

Section: Discussionmentioning

confidence: 99%