Severe cutaneous allergic reactions following topical antifungal therapy

Tang, M.M.; Corti, Michela AngelaMaria; Stirnimann, Regina; Pelivani, Nedzmidin; Yawalkar, Nikhil; Borradori, Luca; Simon, Dagmar

doi:10.1111/j.1600-0536.2012.02151.x

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Antimicrobials1

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Cited by 6 publications

(1 citation statement)

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“…44 Erythema multiforme-like reactions also have been described from topical use. 45 Commercial patch test preparations of the most common imidazole allergens do exist. Nonimidazole antifungals remain a safe option for allergic patients.…”

Section: Antimicrobialsmentioning

confidence: 99%

Contact Allergy to Topical Medicaments, Part 1: A Double-edged Sword

Ng¹

2021

Cutis

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Section: Antimicrobialsmentioning

confidence: 99%

Contact Allergy to Topical Medicaments, Part 1: A Double-edged Sword

Ng¹

2021

Cutis

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The prevalence of skin eruptions and mycoses of the buttocks and feet in aged care facility residents: A cross-sectional study

Nakagami¹,

Takehara²,

Kanazawa³

et al. 2014

Archives of Gerontology and Geriatrics

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Recent advances on topical antimicrobials for skin and soft tissue infections and their safety concerns

Lam

Lee

Wong

et al. 2017

Critical Reviews in Microbiology

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Antimicrobial resistance of disease-related microorganisms is considered a worldwide prevalent and serious issue which increases the failure of treatment outcomes and leads to high mortality. Considering that the increased resistance to systemic antimicrobial therapy often needs of the use of more toxic agents, topical antimicrobial therapy emerges as an attractive route for the treatment of infectious diseases. The topical antimicrobial therapy is based on the absorption of high drug doses in a readily accessible skin surface, resulting in a reduction of microbial proliferation at infected skin sites. Topical antimicrobials retain the following features: (a) they are able to escape the enzymatic degradation and rapid clearance in the gastrointestinal tract or the first-pass metabolism during oral administration; (b) alleviate the physical discomfort related to intravenous injection; (c) reduce possible adverse effects and drug interactions of systemic administrations; (d) increase patient compliance and convenience; and (e) reduce the treatment costs. Novel antimicrobials for topical application have been widely exploited to control the emergence of drug-resistant microorganisms. This review provides a description of antimicrobial resistance, common microorganisms causing skin and soft tissue infections, topical delivery route of antimicrobials, safety concerns of topical antimicrobials, recent advances, challenges and future prospective in topical antimicrobial development.

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Severe cutaneous allergic reactions following topical antifungal therapy

Cited by 6 publications

References 2 publications

Contact Allergy to Topical Medicaments, Part 1: A Double-edged Sword

Contact Allergy to Topical Medicaments, Part 1: A Double-edged Sword

The prevalence of skin eruptions and mycoses of the buttocks and feet in aged care facility residents: A cross-sectional study

Recent advances on topical antimicrobials for skin and soft tissue infections and their safety concerns

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