Severe cytomegalovirus (CMV) community-acquired pneumonia (CAP) precipitating a systemic lupus erythematosus (SLE) flare

Cunha, Burke A.; Gouzhva, Olena; Nausheen, Sara

doi:10.1016/j.hrtlng.2008.07.001

Cited by 19 publications

(14 citation statements)

References 12 publications

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“…Active CMV infection is also frequent in children with SLE [92], and CMV has been implicated in its development and exacerbation [93-97]. Serological signs of active CMV infection have been detected in 10% of patients with SLE, and the presence of viral infection is associated with higher disease activity scores [98].…”

Section: The Virus As An Immunopathological Agent: Autoimmunity Immumentioning

confidence: 99%

Cytomegalovirus-induced immunopathology and its clinical consequences

2011

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Human cytomegalovirus (CMV) is a ubiquitous DNA virus that causes severe disease in patients with immature or impaired immune systems. During active infection, CMV modulates host immunity, and CMV-infected patients often develop signs of immune dysfunction, such as immunosuppression and autoimmune phenomena. Furthermore, active viral infection has been observed in several autoimmune diseases, and case reports have linked primary CMV infection and the onset of autoimmune disorders. In addition, CMV infection promotes allograft rejection and graft-versus-host disease in solid organ and bone marrow transplant recipients, respectively, further implicating CMV in the genesis and maintenance of immunopathological phenomena. The mechanisms by which CMV could induce inhibition of host defense, inflammation, and autoimmunity are discussed, as is the treatment of virus-induced immunopathology with antivirals.

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Section: The Virus As An Immunopathological Agent: Autoimmunity Immumentioning

confidence: 99%

Cytomegalovirus-induced immunopathology and its clinical consequences

2011

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“…For example, pancreatitis, colonic perforation, pneumonia and cavitary lung lesions are rare in both CMV infection and active SLE, but have been reported to occur simultaneously [37–41]. Case reports have documented a variety of symptoms associated with CMV infection in SLE including fatigue, arthralgia, pneumonia and colitis [31,36,42].…”

Section: And Slementioning

confidence: 99%

Cytomegalovirus infection in childhood-onset systemic lupus erythematosus

Rozenblyum¹,

Allen²,

Silverman³

et al. 2013

International Journal of Clinical Rheumatology

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Systemic lupus erythematosus (SLE) is a multisystem disease with significant morbidity and even mortality. Cytomegalovirus (CMV) is a ubiquitous herpesvirus that, similar to SLE, can also lead to significant morbidity and mortality in the immunocompromised host. The relationship between SLE and CMV is complex, with observations suggesting that CMV induces the autoimmunity of SLE in addition to occurring in the immunocompromised host with known SLE. In this article, we first consider CMV infection in the immunocompetent host, and further examine how this infection differs in the patient with SLE. We focus on disease mechanisms, CMV detection and treatment. We review the differences between CMV infection, syndrome and disease, as identifying the correct state will determine the appropriate treatment. We propose guidelines for the screening and management of CMV infection in childhood-onset SLE, and recognize that further study in this population is required to increase our understanding of the interplay between these disease entities.

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“…If a patient with SLE flare has increased serum transaminases, CMV should be suspected as the cause of the SLE flare. 13,14,17,19 CMV characteristically involves the liver, which is manifested by mild elevations of the serum transaminases. SLE patients with flare and increased serum transaminases do not have lupoid hepatitis (autoimmune hepatitis) and should be viewed as having CMV-precipitated SLE flare until proved otherwise.…”

Section: Differential Diagnosismentioning

confidence: 99%

Cytomegalovirus Pneumonia: Community-Acquired Pneumonia in Immunocompetent Hosts

Cunha

2010

Infectious Disease Clinics of North America

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Cytomegaloviruses (CMVs) are DNA viruses and are members of the Herpesviridae family. Morphologically, CMV resembles other herpes viruses, particularly herpes simplex viruses, with important cytopathic differences. CMVs are recognized pathogens that cause community-acquired pneumonia (CAP) in compromised hosts, such as, those who undergo transplants and those on immunosuppressive drugs or steroids. This article discusses the clinical presentation, diagnosis, and therapy for this viral CAP.

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Severe cytomegalovirus (CMV) community-acquired pneumonia (CAP) precipitating a systemic lupus erythematosus (SLE) flare

Cited by 19 publications

References 12 publications

Cytomegalovirus-induced immunopathology and its clinical consequences

Cytomegalovirus-induced immunopathology and its clinical consequences

Cytomegalovirus infection in childhood-onset systemic lupus erythematosus

Cytomegalovirus Pneumonia: Community-Acquired Pneumonia in Immunocompetent Hosts

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