Severe Drug Eruption in Guinea Conakry

Cissé, Mohamed; Tounkara, Thierno; Diané, B.; Soumah, M.M.; Keïta, Moussa; Sako, F.B.; Traore, Fodé Amara; Baldé, H.; Camara, Aissata Dabo; Doumbouya, Alhousseine; Camara, Amara

doi:10.4236/jcdsa.2014.45045

Cited by 3 publications

(4 citation statements)

References 16 publications

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“…Our results suggest that in both children and adults in Africa, the mortality of severe CADRs remains particularly high, linked in part to insufficient technical platform and HIV infection, as already noted by other authors [5,12]. The comparison of the frequencies of the different types of severe CADRs encountered during our study in other countries is difficult because studies differ method of recruiting patients.…”

Section: Discussionsupporting

confidence: 49%

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Severe cutaneous drug reactions in Guinean children: a monocentric retrospective study of 35 cases

Tounkara¹,

Baldé²,

Soumah³

et al. 2018

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Background: Data on Severe cutaneous drug reactions (CADRs) are not common among in sub-Saharan Africa children. The purpose of this study was to document the clinical, etiological and evolutionary aspects of Severe CDRs in children hospitalized at the dermatology department of university hospitals of Conakry. Material and Methods: Retrospective study, conducted from 1 January 2000 to 31 December 2014. Were included all children aged 0-17 years hospitalized for severe CARDs. The data collected were Socio-demographic, clinical, para-clinical and evolution variables. The data was entered and analyzed using the Excel 8.0 software. Results: During a study period, 4437 patients of all ages was hospitalized in dermatology department. 35 patients were included with an average age of 11.3 years and a sex ratio of 1.5.The main clinical patterns were: Stevens Johnson syndrome 37.14% (13/35) Lyell syndrome 25.71 % and generalized bullous fixed eruption 22.85%. The drug was identified as 32 patients (91.42%): Sulfadoxine-Pyriméthamine 40.62%, cotrimoxazole 21.85%, nevirapin 12.5%, ampicillin 6.25%, traditional Pharmacopoeia 6.25% and griseofulin 3.12%. It was taken following self-medication in 14 patients, including a parental initiative in 9 patients. 7 patients had a history of drug allergy and 4 were HIV positive. We recorded 5 deaths. Conclusion: Our study confirms the rarity of severe CADRs in children. The importance of the sulfadoxine-pyrimethamine in the occurrence of severe CADRs in children is the particularity of our series.

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Section: Discussionsupporting

confidence: 49%

“…They are the cause of hospitalization in dermatology services for about 1.5% of patients in France [2], 4.11% in Tunisia [3], 27% in Togo [4], 10.40% patients in Guinea [5] and have a high degree of semiological variability.…”

Section: Introductionmentioning

confidence: 99%

Severe cutaneous drug reactions in Guinean children: a monocentric retrospective study of 35 cases

Tounkara¹,

Baldé²,

Soumah³

et al. 2018

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“…10 Penelitian yang dilakukan Mohamed dkk dan Leelavathy dkk juga menyatakan hal yang sama. 15,16 Selain nevirapin, ada beberapa obat ARV yang juga dikaitkan dengan kejadian erupsi alergi obat seperti zidovudin (2,9%), lamivudin (2,9%), tenofovir (5-7%) dan efavirenz (14,5%). 5,10 Beberapa penelitian sebelumnya juga menyebutkan obat ARV yang dikaitkan dengan erupsi obat pada pasien HIV/AIDS.…”

Section: Pembahasanunclassified

Manifestasi Erupsi Alergi Obat Antiretroviral Pada Pasien HIV/AIDS di Klinik Teratai Rsup Dr. Hasan Sadikin Bandung Periode 2005 – 2014

Armeinesya

Rowawi²,

Hamda³

2018

jsk

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Kasus human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) telah menjadi masalah kesehatan dunia. High active antiretroviral therapy (HAART) telah menurunkan angka kematian dan kesakitan pada pasien HIV. Pasien HIV memilki risiko tinggi mengalami erupsi alergi obat dibandingkan masyarakat umum. Penelitian ini bertujuan untuk mengindentifikasi manifestasi erupsi alergi obat ARV pada pasien HIV/AIDS periode 2005–2014 di Klinik Teratai RSUP Dr. Hasan Sadikin Bandung. Penelitian ini menggunakan pendekatan cross-sectional. Data dikumpulkan dari rekam medis pasien HIV/AIDS dengan erupsi alergi obat ARV di Klinik Teratai RSUP Dr. Hasan Sadikin Bandung tahun 2005–2014. Dalam penelitian ini didapatkan sebanyak 111 pasien HIV/AIDS mengalami erupsi alergi obat karena ARV. Erupsi alergi obat ARV banyak terjadi pada wanita (55%) dan pada rentang usia 20-29 tahun (55%). Jumlah CD4 pada pasien HIV/AIDS dengan erupsi alergi obat saat pertama kali terdiagnosis HIV terbanyak adalah <200 sel/mm3 (55%). Manifestasi kulit yang paling umum terjadi adalah ruam makulopapular (89,7%). Reaksi erupsi alergi obat umumnya disebabkan oleh nevirapin (82,5%). Dari penelitian ini didapatkan bahwa ruam makulopapular merupakan manifestasi erupsi alergi obat ARV yang paling sering muncul. Obat yang paling banyak ditemukan menyebabkan erupsi alergi obat adalah nevirapin. Kata kunci: erupsi alergi obat, HIV/AIDS, obat ARV

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“…Any unintended harmful reaction to a medicine or drug is known as an adverse drug reaction (ADR) according Guinea [6] and have a high degree of semiological variability. Two per cent of these can be severe, with severe sequelae or life threatening [7] .…”

Section: Introductionmentioning

confidence: 99%

Cutaneous Adverse Drug Reaction in Morocco – Evaluating the Knowledge of Pharmacists

2020

IJFMT

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Background. Pharmacy professionals, as the most available members of medical team, have an important role in educating patients about Cutaneous Adverse Drug Reaction (CADR). Our aim was to evaluate pharmacists' knowledge of the cutaneous drug reaction, and their recommendations under hypothetical situations, through a written questionnaire. Methods. based cross-sectional study was conducted among community pharmacists working at the private sector of the rabat-salé-zemmour-zaer region using a structured interviewing questionnaire. Results. Ninety-eight pharmacists completed the questionnaire (response rate 48%). The mean overall score was 52.87 ± 23.19% correct answers. The majority of pharmacists (66,32 %) estimated that they view more than a Patient with CADR each month, and only forty-seven pharmacists underwent CADR related training during the year preceding the survey. Pharmacists obtained the highest correct scores on the true/false statements inquiring about Cutaneous reaction due to drugs definition, classification and the most common medication classes implicated in Cutaneous reaction due to drugs, Overall, the true/false questions were relatively easier to address, compared with the multiple choice questions (63.60 ± 13.15% vs. 51.18 ± 24.12%, respectively; p < 0.01). Only 14 pharmacists were familiar with Cutaneous reaction due to drugs sach as ( Drug Reaction With Eosinophilia, contact dermatitis, Nail Disorders, bullous pemphigoid ). Longer time since training completion was associated with a lower total score (38,77 ± 9% vs. 61,22 ± 11% for the pharmacists who were in practice 5 years or less and those with longer time in practice, respectively; p < 0.05). Conclusion. Pharmacists were knowledgeable regarding some aspects of CADR. However, our study, as in previous studies among health care professionals, identified some gaps in knowledge. These findings indicate the need for better education of pharmacists regarding CADR and its supported.

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Severe Drug Eruption in Guinea Conakry

Cited by 3 publications

References 16 publications

Severe cutaneous drug reactions in Guinean children: a monocentric retrospective study of 35 cases

Severe cutaneous drug reactions in Guinean children: a monocentric retrospective study of 35 cases

Manifestasi Erupsi Alergi Obat Antiretroviral Pada Pasien HIV/AIDS di Klinik Teratai Rsup Dr. Hasan Sadikin Bandung Periode 2005 – 2014

Cutaneous Adverse Drug Reaction in Morocco – Evaluating the Knowledge of Pharmacists

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