Severe eosinophilic asthma and aspirin-exacerbated respiratory disease associated to eosinophilic gastroenteritis treated with mepolizumab: a case report

Abstract

Background: Mepolizumab (MEP) is the first anti Interleukin (IL)-5 add-on therapy approved for the treatment of severe refractory eosinophilic asthma. Case presentation:We describe here the case of a 49 years-old woman with Aspirin-exacerbated respiratory disease (AERD), chronic rhinosinusitis, nasal polyposis and eosinophilic gastroenteritis successfully treated with MEP. Several laboratory and clinical items improved during therapy; moreover MEP showed to be useful as steroid sparing agent. Conclusions:This case supports that the use of mepolizumab can be effective also in other eosinophilic conditions different from asthma and this opens to new therapeutic perspectives. Publisher's NoteSpringer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Basophil activation and serum IL‐5 levels as possible monitor biomarkers in severe eosinophilic asthma patients treated with anti‐IL‐5 drugs

“…During the follow-up, serum IL-5 levels showed a significant increase, almost exclusively in the mepolizumab group (Figure 1A), as previously observed. 7,8 Serum IL-5 levels did not differ at T0, T3, and T6 among patients with different treatment responses (not shown).…”

Appraisal of the Real-World Effectiveness of Biologic Therapies in Aspirin-Exacerbated Respiratory Disease

“…[20][21][22][23][24] Some reports have shown efficacy of antieIL-5/ IL-5Ra therapy in AERD. 19,25 Investigational biologics such as antiethymic stromal lymphopoietin may also have potential for future use in AERD, because thymic stromal lymphopoietin has been shown to contribute to AERD pathogenesis. 26 In this retrospective study, we aimed to explore various clinical outcomes in subjects with AERD who had used 1 or more of the 5 available respiratory biologics for the management of this disease.…”

Organ-Specific Hypereosinophilic Syndrome Presenting as Eosinophilic Gastroenteritis

“…Relapses are common and may require repeat dosing or a long-term maintenance regimen. Table 2 quickly summarizes the other available options [15][16][17][18][19]. Our patient was diagnosed with HES and EGID and quickly responded to steroids.…”