Severe IgA-mediated autoimmune haemolytic anaemia in Hodgkin lymphoma: A very rare event

Moncharmont, P.; Ghesquières, Hervé; Sebban, Catherine; Debourdeau, Philippe; Pavic, Michel; Biron, Pierre; Rigal, Dominique

doi:10.1080/10428190601120357

Cited by 6 publications

(4 citation statements)

References 14 publications

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“…The incidence of autoimmune disease at diagnosis of HL is comparable to rates reported in a limited number of studies, which range between 2.6 and 13.6% …”

Section: Discussionsupporting

confidence: 76%

Treatment outcomes of children with Hodgkin lymphoma between 2000 and 2010: First report by the South African Children's Cancer Study Group

Geel

Chirwa

Rowe

et al. 2017

Pediatric Blood & Cancer

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“…The incidence of autoimmune disease at diagnosis of HL is comparable to rates reported in a limited number of studies, which range between 2.6 and 13.6% …”

Section: Discussionsupporting

confidence: 76%

Treatment outcomes of children with Hodgkin lymphoma between 2000 and 2010: First report by the South African Children's Cancer Study Group

Geel

Chirwa

Rowe

et al. 2017

Pediatric Blood & Cancer

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“…An analysis including 5,177 patients with AIHA included only 5 cases (<0.1%) due to autoantibodies which were exclusively of the IgA isotype . Case reports of IgA‐mediated WAIHA include an infant, a woman with superficial thrombophlebitis, a patient with Hodgkin lymphoma, and a patient with a history of renal transplant .…”

Section: Discussionmentioning

confidence: 99%

Finding the elusive and causative autoantibody: An atypical case of autoimmune hemolytic anemia

Fetzko

Ahmed

Cooling

2015

Clinical Case Reports

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Key Clinical MessageAn isolated IgA-mediated autoimmune hemolytic anemia can present a diagnostic challenge. When a routine direct antiglobulin test (DAT) is negative but clinical suspicion remains high, further testing with monospecific antisera should be performed. As with IgG-mediated WAIHA, steroids are first-line treatment, though splenectomy is often required to achieve a durable treatment response.

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“…It is not clear why sometimes AIHA manifests after successful treatment and when the patient is in complete remission. Further research is needed to explain these observations [5, 6, 13, 14]. …”

Section: Discussionmentioning

confidence: 99%

Lymphocyte Rich Hodgkin's Lymphoma Presented with Warm Hemolytic Anemia: A Case Report and Literature Review

Hurtado-Cordovi

Verma

Gotlieb

et al. 2011

Case Reports in Hematology

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Hodgkin's lymphoma accounts for ten percent of all lymphomas. In the United States, there are about 8000 new cases every year. This paper describes a case of lymphocyte-rich Hodgkin's lymphoma (LRHL) manifested by autoimmune hemolytic anemia (AIHA). A 27-year-old Israeli male presented with dizziness associated with one month of low-grade fevers and night sweats; he also complained of persistent cough, pruritus, and ten-pound weight lost during this time. The CBC revealed hemoglobin of 5.9 gm/dL, and direct Coomb's test detected multiple nonspecific antibodies consistent with the diagnosis of AIHA. Chest, abdomen, and pelvic CT scan showed mediastinal lymphadenopathy and splenomegaly. Lymph node biopsy revealed classic LRHL. AIHA resolved after completion of the first cycle of chemotherapy with adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD); after six cycles, he went into complete remission. Although infrequent, AIHA can be responsible for the presenting symptoms of HL.

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Severe IgA-mediated autoimmune haemolytic anaemia in Hodgkin lymphoma: A very rare event

Cited by 6 publications

References 14 publications

Treatment outcomes of children with Hodgkin lymphoma between 2000 and 2010: First report by the South African Children's Cancer Study Group

Treatment outcomes of children with Hodgkin lymphoma between 2000 and 2010: First report by the South African Children's Cancer Study Group

Finding the elusive and causative autoantibody: An atypical case of autoimmune hemolytic anemia

Lymphocyte Rich Hodgkin's Lymphoma Presented with Warm Hemolytic Anemia: A Case Report and Literature Review

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