Severe Intrauterine Growth Restriction Pregnancies Have Increased Placental Endoglin Levels

Yinon, Yoav; Nevo, Ori; Xu, Jin; Many, Ariel; Rolfo, Alessandro; Todros, Tullia; Post, Martin; Caniggia, Isabella

doi:10.2353/ajpath.2008.070640

Cited by 102 publications

(80 citation statements)

References 42 publications

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“…Oxygen will also regulate the placental expression of endoglin via TGF-beta3. Reduced placental perfusion leading to placental hypoxia might contribute to the increased expression of endoglin (Yinon et al, 2008). In our study, we found that the increased sENG levels in normal twin amniotic fluids, which compared with normal singletons.…”

Section: Figuresupporting

confidence: 57%

Early Anti-Angiogenic Proteins Expression in Amniotic Fluid of Twin Fetuses

et al. 2011

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Multiple pregnancies are thought to be associated with a high incidence of perinatal complications such as preterm labor, preeclampsia and low birth weight. But the true mechanisms of these obstetric complications are still uncertain. The components of amniotic fluid reflect the pathophysiology features of the fetus. Amniotic fluid soluble fms-like tyrosine kinase 1(sFLT1), soluble endoglin (sENG), and adiponectin reflect the oxidative stress and pro-inflammatory status and are associated with preeclampsia and fetal growth restriction. We prospectively collected amniotic fluids during amniocentesis from singleton and twin pregnancies. Samples were analyzed for levels of sFLT1, sENG, and adiponectin by enzyme-linked immunosorbent assay. The levels of sENG and sFLT1 were significantly increased in twin pregnancies. Adiponectin was not significantly different between the two groups. These findings would suggest that twin fetuses suffer from more oxidative stress and pro-inflammatory status from the early trimesters.

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Section: Figuresupporting

confidence: 57%

Early Anti-Angiogenic Proteins Expression in Amniotic Fluid of Twin Fetuses

et al. 2011

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“…Levine et al (11) demonstrated higher circulating endoglin in women with SGA neonates. Yinon et al (12) have shown that placental endoglin mRNA concentration were higher in severely growth restricted infants. Jeyebalan et al (13) noted that maternal circulating endoglin concentrations were not higher in growth restricted babies compared to uncomplicated pregnancies.…”

Section: Discussionmentioning

confidence: 99%

Fetal ve erken postnatal serum endoglin düzeylerinin doğum ağırlığı ve maternal preeklampsi ile ilişkisi

Turan

Türkyılmaz²,

Elbeğ³

et al. 2016

J Contemp Med

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ORJINAL RESEARCH oRJİNAL ARAŞTIRMA Amaç: Bu çalışmanın amacı fetal ve erken postnatal serum endoglin düzeylerinin fetal büyümedeki rolünü ve maternal preeklampsinin endoglin düzeylerine olan ilişkisini araştırmaktır. Materyal ve Method:Bu çalışmaya 55 yenidoğan prospektif olarak çalışmaya dahil edildi ve 4 gruba ayrıldı:1)Normal gebelik ve gebelik haftasına göre düşük doğum ağırlıklı yenidoğanlar (n:13,small for gestational age:SGA) 2)normal gebelik ve gebelik haftasına göre fazla doğum ağırlıklı yenidoğanlar (n:19, large for gestational age:LGA)3) Preeklamptik anneden doğan gebelik haftasına göre normal ağırlıklı yenidoğanlar (n:12, appropriate for gestational age:AGA)) 4)kontrol grup: preeklampsi ve herhangi bir hastalığı olmayan anneden doğan gebelik haftasına göre normal ağırlıklı yenidoğanlar (n:11).Kanlar umblikal kordondan ve postnatal 4.saatte periferal venden toplandı. Serum endoglin düzeyleri ELISA kit kullanılarak ölçüldü. Bulgular: Endoglin çalışılan tüm umblikal kord ve yenidoğan serumlarında saptandı. Fetal ve erken postnatal serum endoglin düzeyleri arasında SGA, LGA, preeklamptik ve kontrol grupları bakımından fark saptanmadı. Fetal ve erken postnatal serum endoglin düzeyleri SGA grupta AGA gruptan yüksek saptandı. Sonuçlar: Fetal ve erken postnatal serum endoglin düzeyleri yenidoğanlarda değişmemektedir. SGA yenidoğanlarda serum endoglin düzeyleri farklılık göstermektedir. Sonuçlarımız artan endoglin düzeylerinin SGA patofizyolojisinde rol oynayabileceğini düşündürmektedir.Normal ve komplike gebeliklerden doğan yenidoğanlarda endoglinin fetal büyümedeki rolünu belirlemek için geniş serili çalışmalara ihtiyaç vardır.

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“…These finding suggest that endoglin levels may responsible for the pathogenesis of PE and/or IUGR. 17 Increase in soluble endoglin may, in turn, create an anti-angiogenic milieu in the circulation and lead to the maternal manifestations of preeclampsia. The effect of gestational age at delivery on the differences in level is not known and further studies are required in this aspect to explore whether primary pathology is uteroplacental response to fetal placental vasculature or uterine circulation constraints on placenta and foetus.…”

Section: Discussionmentioning

confidence: 99%