Severe mood disorders and schizophrenia in the adult offspring of antenatally depressed mothers in the Northern Finland 1966 Birth Cohort: Relationship to parental severe mental disorder

Taka-Eilola, Tiina; Veijola, Juha; Murray, Graham; Koskela, Jari; Mäki, Pirjo

doi:10.1016/j.jad.2019.02.011

Cited by 12 publications

(10 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the quantitative analyses of eight studies, maternal prenatal depression increased the risk of depression among offspring (OR = 1.36; 95% CI 1.07–1.72, k = 8, N = 36,985) (Betts, Salom, et al., 2015 ; Herva et al., 2008 ; Kingsbury et al., 2016 ; Pawlby et al., 2009 ; Pearson et al., 2013 , 2013 ; Plant et al., 2015 ; Taka‐Eilola Nee Riekki et al., 2019 ; Zohsel et al., 2017 ). There was a statistically significant heterogeneity ( I 2 = 76%, p < .01).…”

Section: Resultsmentioning

confidence: 99%

Research Review: Developmental origins of depression – a systematic review and meta‐analysis

D’Arcy

Meng

2020

Child Psychology Psychiatry

View full text Add to dashboard Cite

Background: Many observational studies have found a direct association between adverse in utero, perinatal and postnatal exposures and offspring's depression. These findings are consistent with the 'developmental origins of disease hypothesis'. But no review has comprehensively summarized the roles of these exposures. This review aims to systematically scrutinize the strength of associations between individual prenatal, perinatal, and postnatal exposures and subsequent depression in offspring. Methods: We conducted a systematic review and meta-analysis to synthesize the literature from the EMBASE, HealthStar, PsychoInfo, and Medline databases since their inception to September 1, 2019. English language articles on population-based prospective cohort studies examining the associations between in utero, perinatal, and postnatal exposures and offspring's depression were searched. Random-effects models were used to calculate pooled estimates, and heterogeneity and sensitivity tests were conducted to explore potential confounders in the relationships of depression and early-life factors. Qualitative analysis was also conducted. Results: Sixty-four prospective cohort studies with 28 exposures studied in the relationships to offspring's depression met inclusion criteria. The meta-analysis found 12 prenatal, perinatal, and postnatal characteristics were associated with an increased risk of depression in offspring: low birth weight, premature birth, small gestational age, maternal education, socioeconomic status, having younger parents (<20 years), having older parents (≥35 years), maternal smoking, paternal smoking, maternal stress, maternal anxiety, and prenatal depression. Heterogeneity and sensitivity tests supported the findings. By and large, study characteristics had no effects on conclusions. Qualitative analyses generally supported the findings of meta-analysis and reported on additional risk factors. Conclusions: This review provides a robust and comprehensive overview of the lasting psychopathological effects of in utero, perinatal, and postnatal exposures. The findings highlight the need for clinical and public health interventions focusing on the identified risk factors. Large prospective cohort studies are warranted to investigate the combined effects of multiple co-existing early-life exposures.

show abstract

Section: Resultsmentioning

confidence: 99%

Research Review: Developmental origins of depression – a systematic review and meta‐analysis

D’Arcy

Meng

2020

Child Psychology Psychiatry

View full text Add to dashboard Cite

show abstract

“…Key characteristics (ie, title, author information, study design, sample size, location, measuring scales, mean ages of offspring at assessment, and number of male and female participants) of the included articles were reported based on the MOOSE guidelines 63 and are shown in Table 1. 39,42,43,[60][61][62] Primary Analysis (Figure 2). The posterior probability (PP) that the pooled OR was greater than 1 was 98.6%; the posterior distribution for the pooled OR in Figure 3 provides a graphic summary of the association.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Second, a single standard diagnostic criterion for depression or major depressive disorder in both the mothers and offspring was not specified. For example, Taka-Eilola et al 62 used a single structured question during antenatal visits for its 1966 birth cohort study due to the absence of specific screening scales at the time. Although this could be a potential limitation, it also makes the study more generalizable by being less dependent on a single diagnostic method.…”

Section: Limitationsmentioning

confidence: 99%

Risk of Depression in the Adolescent and Adult Offspring of Mothers With Perinatal Depression

et al. 2020

View full text Add to dashboard Cite

IMPORTANCE Maternal depression during pregnancy is associated with emotional and behavioral difficulties of offspring during childhood that can increase the risk of depression in adolescence and adulthood. OBJECTIVE To investigate the association between perinatal maternal depression and an increased long-term risk of depression in their adolescent and adult offspring. DATA SOURCES A systematic search of the electronic databases of PubMed and PsycINFO was conducted from May 2019 to June 2019. STUDY SELECTION A total of 6309 articles were identified, of which 88 articles were extracted for full-text review by 2 reviewers. Only articles reporting data from prospective longitudinal studies that assessed maternal depression during antenatal and/or postnatal periods and resulting offspring 12 years or older with measures of established psychometric properties were included. Exclusion criteria consisted of all other study designs, mothers with other medical and psychiatric comorbidities, and offspring younger than 12 years. DATA EXTRACTION AND SYNTHESIS Data were extracted by 2 independent reviewers, and discrepancies were mediated by an expert third reviewer. Meta-analysis was performed using Bayesian statistical inference and reported using Meta-analysis of Observational Studies in Epidemiology (MOOSE) guideline. The association of depression timing with the sex of offspring was explored using metaregression. MAIN OUTCOMES AND MEASURES Offspring depression was evaluated using standardized depression scales or clinical interviews. RESULTS Six studies with a total of 15 584 mother-child dyads were included in the meta-analysis, which found the offspring of mothers who experienced perinatal depression to have increased odds of depression (odds ratio [OR], 1.70; 95% credible interval [CrI], 1.60-2.65; posterior probability [PP] [OR >1], 98.6%). Although metaregression found no evidence for an overall association between perinatal depression timing and offspring depression (antenatal vs postnatal, PP [OR >1] = 53.8%), subgroup analyses showed slightly higher pooled odds for the antenatal studies (OR, 1.78; 95% CrI, 0.93-3.33; PP [OR >1] = 96.2%) than for the postnatal studies (OR, 1.66; 95% CrI, 0.65-3.84; PP [OR >1] = 88.0%). Female adolescent offspring recorded higher rates of depression in metaregression analyses, such that a 1% increase in the percentage of female (relative to male) offspring was (continued)

show abstract

“…Chronic stress during early life, such as exposure to prenatal and postnatal depression or deficits in parental care, can have persistent adverse behavioural effects (Murgatroyd et al., 2010, 2015; Peña et al., 2017). Such long‐term stress‐related disruptions in behaviour have been documented in both human and rodent studies of offspring exposed to a variety of early‐life stressors, including maternal depression (Hammen & Brennan, 2003; Peña et al., 2017; Raposa et al., 2014; Taka‐Eilola (nèe Riekki) et al, 2019). Offspring subjected to early‐life stress have increased susceptibility to maternal depression themselves, suggesting genetic and/or epigenetic mechanisms by which maternal stress could be intergenerationally inherited (Champagne, 2008; Elwood et al., 2019; Kluczniok et al., 2016; Nephew et al., 2015; Séjourné et al., 2011).…”

Section: Introductionmentioning

confidence: 99%

“…Taka-Eilola (nèe Riekki) et al, 2019). Offspring subjected to early-life stress have increased susceptibility to maternal depression themselves, suggesting genetic and/or epigenetic mechanisms by which maternal stress could be intergenerationally inherited (Champagne, 2008;Elwood et al, 2019;Kluczniok et al, 2016;Nephew et al, 2015;Séjourné et al, 2011).…”

mentioning

confidence: 99%

Intergenerational changes in hippocampal transcription in an animal model of maternal depression

Alyamani

Nephew

Murgatroyd

2021

Eur J of Neuroscience

View full text Add to dashboard Cite

Chronic stress during early life, such as exposure to prenatal and postnatal depression or deficits in parental care, can have persistent adverse behavioural effects (Murgatroyd et al., 2010(Murgatroyd et al., , 2015Peña et al., 2017). Such long-term stressrelated disruptions in behaviour have been documented in both human and rodent studies of offspring exposed to a variety of early-life stressors, including maternal depression (Hammen

show abstract

Severe mood disorders and schizophrenia in the adult offspring of antenatally depressed mothers in the Northern Finland 1966 Birth Cohort: Relationship to parental severe mental disorder

Cited by 12 publications

References 60 publications

Research Review: Developmental origins of depression – a systematic review and meta‐analysis

Research Review: Developmental origins of depression – a systematic review and meta‐analysis

Risk of Depression in the Adolescent and Adult Offspring of Mothers With Perinatal Depression

Intergenerational changes in hippocampal transcription in an animal model of maternal depression

Contact Info

Product

Resources

About