Severe neonatal anemia affected by massive fetomaternal hemorrhage: a single-center retrospective observational study

Tao, Enfu; Ye, Diya; Gao, Long; Hu, Yuting; Fu, Qibo; Yuan, Tianming; Jiang, Mizu

doi:10.1080/14767058.2020.1845313

Cited by 12 publications

(6 citation statements)

References 28 publications

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“…We did not identify any findings suggestive of intrauterine infection, including TORCH (toxoplasmosis, rubella, cytomegalovirus, herpes simplex, and other organisms), coagulation system abnormalities, or blood type incompatibility. In contrast, the high value of alpha‐fetoprotein (1510.3 ng/mL) from maternal blood indicated that the anemia of the neonate was caused by severe FMH 3 . The maternal blood also contained anti‐HLA‐A31 and B61 antibodies, and a cross‐matching test between mother's serum and father's platelets was positive.…”

Section: Figurementioning

confidence: 98%

“…In contrast, the high value of alpha-fetoprotein (1510.3 ng/mL) from maternal blood indicated that the anemia of the neonate was caused by severe FMH. 3 The maternal blood also contained anti-HLA-A31 and B61 antibodies, and a cross-matching test between mother's serum and father's platelets was positive. Genetic analysis of HLA-and HPA-typing was shown in Table S1.…”

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confidence: 98%

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Neonatal alloimmune thrombocytopenia associated with fetomaternal hemorrhage

Kuroda,

Kashimada,

Okazaki

2023

Pediatrics International

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Section: Figurementioning

confidence: 98%

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confidence: 98%

Neonatal alloimmune thrombocytopenia associated with fetomaternal hemorrhage

Kuroda,

Kashimada,

Okazaki

2023

Pediatrics International

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“…Alpha-fetoprotein (AFP), a fetal glycoprotein, has been under clinical scrutiny. Certain observations indicate that placental implantation can cause a surge in AFP concentrations, sometimes escalating to levels 2 to 5 times the standard range [9]. Placental growth factor (PIGF) is another pivotal entity.…”

Section: Introductionmentioning

confidence: 99%

Predictive value of coagulation function, alpha-fetoprotein and placental growth factor in patients with perilous placenta previa

Qiao

2024

Am J Transl Res

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Objective: To analyze the predictive value of coagulation function, alpha-fetoprotein (AFP) and placental growth factor (PIGF) for postpartum hemorrhage in patients with perilous placenta previa (PPP). Methods: The clinical data of 104 PPP patients were retrospectively analyzed. The patients were divided into a hemorrhage group (n=68) and a non-hemorrhage group (n=36). A total of 55 healthy pregnant women were recruited as controls. The coagulation function, AFP and PIGF were compared between the three groups. Multivariate logistic regression was performed to determine independent risk factors for hemorrhage. Results: PT, TT, APTT, FIB and AFP were significantly higher while PIGF was lower in the PPP group than the control group (all P<0.05). Placental adhesion (OR 3.924, 95% CI 1.389-11.083, P=0.01), anterior placenta (OR 4.583, 95% CI 1.589-13.22, P=0.005), AFP (OR 0.208, 95% CI 0.068-0.635, P=0.006) and PIGF (OR 3.963, 95% CI 1.385-11.34, P=0.01) were independent risk factors for hemorrhage. Conclusion: Coagulation function, AFP and PIGF could predict postpartum hemorrhage in PPP patients.

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“…Two or three out of every 10,000 pregnant women are reported to have FMH (fetomaternal haemorrhage) ( Tao et al, 2022 ). The essence of detecting FMH is the quantitative detection of fetal red blood cells in the peripheral blood of pregnant women ( Troia et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

A novel enzyme-linked immunostaining technique based on silk membrane for the prenatal detection of fetomaternal haemorrhage

Li,

Duan

et al. 2023

Front. Bioeng. Biotechnol.

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Objective: Developing a simple, rapid, reliable, sensitive, and cost-effective method for prenatal detection of fetomaternal haemorrhage by combining multi-aperture silk membrane with enzyme-linked immunosorbent assay (ELISA), which does not require any complicated instruments and can be visually colored, so as to provide a new method for clinical detection of fetomaternal haemorrhage.Methods: As a carrier, a chemically treated silk membrane was used to immobilize anti-A/anti-B antibody reagent. PBS washed slowly after vertically dropping red blood cells. After adding biotin-labeled anti-A/anti-B antibody reagent, PBS is slowly washed, enzyme-labeled avidin is added, and TMB is used for color development after washing.Results: When there were both anti-A and anti-B fetal erythrocytes in pregnant women’s peripheral blood, the final color was dark brown. When there are no anti-A and anti-B fetal red blood cells in pregnant women’s peripheral blood, the final color development results do not change, which corresponds to the color of chemically treated silk membrane.Conclusion: The new enzyme-linked immunosorbent assay (ELISA) based on a silk membrane can distinguish fetal red blood cells from maternal red blood cells prenatally and can be used for prenatal detection of fetomaternal haemorrhage.

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Severe neonatal anemia affected by massive fetomaternal hemorrhage: a single-center retrospective observational study

Cited by 12 publications

References 28 publications

Neonatal alloimmune thrombocytopenia associated with fetomaternal hemorrhage

Neonatal alloimmune thrombocytopenia associated with fetomaternal hemorrhage

Predictive value of coagulation function, alpha-fetoprotein and placental growth factor in patients with perilous placenta previa

A novel enzyme-linked immunostaining technique based on silk membrane for the prenatal detection of fetomaternal haemorrhage

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