Severe obstructive sleep apnea associated with stage iii-iv lung cancer mortality: a cohort study

Huang, Hsuan-Rong; Lin, Shi‐Ming; Chuang, Li‐Pang; Li, H.-Y.; Chang, Chi-Jen; Chen, N.-H.

doi:10.1016/j.sleep.2019.11.443

Cited by 1 publication

(2 citation statements)

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“…31,32 Our findings confirmed that HIF1α was highly expressed in Lung adenocarcinoma patients with OSA but had no dose relationship with the AHI, which is inconsistent with reports that the expression of HIF1α was associated with the severity of OSA in lung cancer. 20 Due to the patients included in the cohort had more severe OSA (AHI >30, n=11, 59. ±20.8) comparing us (AHI >30, n=4, 38.9±11.6).…”

Section: Discussionmentioning

confidence: 99%

“…Several studies are in favor of a link between the increasing severity of OSA and lung cancer incidence and mortality. 6 , 20 , 21 However, the association of the severity of OSA in specific Lung adenocarcinoma have not yet been fully elucidated. Firstly, lung adenocarcinoma patients were classified into three groups according to OSA severity as measured by AHI, and there was a significant difference in AHI, ODI, LS P O 2 , as well as TNM stage and Metastatic spreading.…”

Section: Discussionmentioning

confidence: 99%

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MiR-142-3p as an Indicator of OSA Severity Predicts Prognosis in Lung Adenocarcinoma with OSA

Yang¹,

He²,

Zhang³

et al. 2022

NSS

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The aim was to explore the correlation between Obstructive sleep apnea (OSA) and Lung adenocarcinoma malignant prognosis and evaluate the miR-142-3p was used as an OSA severity indicator to predict the prognosis of Lung adenocarcinoma patients. Methods: This study comprised of 21 diagnosed lung adenocarcinoma patients with or without OSA. The sleep-related variables and tumor pathology were recorded. Hypoxia-inducible factor-1α (HIF1α) and ki67 expression were analyzed by immunohistochemistry in tumor samples. Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to assess the level of miR-142-3p. Results: Lung adenocarcinoma with OSA showed higher apnea-hypopnea index (AHI), oxygen desaturation index (ODI), and the lower lowest pulse oxygen saturation (LS P O 2 ) compared to Lung adenocarcinoma without OSA (P<0.05), and patients with severer OSA have an advanced TNM stage (P=0.004) and metastasis rate (p=0.032). In addition, OSA may down-regulate the miR-142-3p expression in patients with Lung adenocarcinoma, and the patients with low miR-142-3p expression exhibited severe OSA. MiR-142-3p levels significantly decreased in the advanced TNM stage (p=0.015), and the expression of miR-142-3p was negatively associated with AHI (r= −0.505, p=0.020), ODI (r= −0.513, p=0.017). Conclusion: OSA severity may increase Lung adenocarcinoma malignant prognosis. OSA may down-regulate the expression of miR-42-3p. The expression of miR-142-3p was inversely correlated with AHI and ODI as a surrogate of OSA severity. Additionally, the low miR-142-3p expression level was significantly associated with advanced TNM stage in Lung adenocarcinoma patients.

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Section: Discussionmentioning

confidence: 99%