Severe Ocular Bacterial Infections: A Retrospective Study Over 13 Years

Attisano, C; Cibinel, Monica; Strani, G. F.; Panepinto, Giovanna; Pollino, Cristina; Furfaro, Gabriella; Giardini, Franco; Machetta, Federica; Grignolo, Federico; Grandi, Giuseppe

doi:10.1080/09273948.2016.1181767

Cited by 5 publications

(2 citation statements)

References 11 publications

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“…Streptococcus is an important pathogen that causes panophthalmitis [13] and other diseases [14]. However, the distribution and drug resistance of Streptococcus in the conjunctival sac of children are rarely reported.…”

Section: Introductionmentioning

confidence: 99%

Bacteriological profiles and drug susceptibility of Streptococcus isolated from conjunctival sac of healthy children

Zhang

Zhou

et al. 2020

BMC Pediatr

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Background: To investigate bacterial flora and antibiotics susceptibility of Streptococcus pneumoniae isolated from the conjunctival sac of heathy children. Methods: Bacteria were isolated from the secretions of conjunctival sac of healthy children between 2015 and 2018. Antimicrobial susceptibility of isolated S. pneumoniae strains were determined using microbroth dilution method. Results: The sac secretions were collected from a total of 6440 children. 1409 samples presented bacterial growth, accounting for 21.8% of the samples. Among the 22 bacterial species isolated, 528 samples presented Grampositive Staphylococcus spp. growth, accounting for 37.4% of the isolates, followed by Corynebacterium spp., counting for 30% of the isolates and Streptococcus pneumoniae, counting for 21.4% of the isolates. Antibiotics susceptibility tests showed that the majority of S. pneumoniae isolates were sensitive to most antibiotics tested. However, 72.8 and 81.2% of the isolates were resistant to erythromycin and tetracycline, respectively, and over 10% of them were resistant to gentamicin, tobramycin and rifampicin. Conclusions: The bacterial flora of healthy children is mainly consisted of Gram-positive bacteria belonging to Corynebacterium spp. and Streptococcus spp.; most of S. pneumoniae isolates were sensitive to antibiotics except erythromycin and tetracycline.

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Section: Introductionmentioning

confidence: 99%

Bacteriological profiles and drug susceptibility of Streptococcus isolated from conjunctival sac of healthy children

Zhang

Zhou

et al. 2020

BMC Pediatr

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“…Ocular bacterial infection is the most common cause of infectious keratitis and related to various types of ocular infections [174]. The infectious pathogens can potentially cause serious intraocular infections leading to visual impairments and blindness [175]. Utilization of antibiotics is commonly treated in form of topical installations (e. g. eye drop, ointment) as it is the most convenient and non-invasive route of drug administration [176].…”

Section: Discussionmentioning

confidence: 99%

Biopolymer nanocomposites for food and healthcare applications

Siripongpreda

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This dissertation focuses on development of biopolymers by integrating nanomaterials to improve the properties of pristine polymers for enhancing the performances of chemical sensors and laser desorption/ionization mass spectroscopy (LDI-MS) applied for food quality control health monitoring and biomedical applications. The dissertation is divided into 4 parts: the first part, polylactic acid and cellulose were used for dual detection platform of biogenic amines for food spoilage indication. Highly porous PLA film is fabricated by adding nanosized calcium carbonate resulted in high sensing element entrapment. On another side of platform, pristine cellulose is modified with graphene oxide and exploited a substrate for LDI-MS. This dual platform is used for food quality monitoring. The second part, a bacterial nanocellulose hydrogel with reswelling ability and high swelling ratio is fabricated by introducing carboxymethyl cellulose into the nanocellulose network, and the obtained hydrogel is used as a colorimetric sensor for sweat pH and glucose. The third part, the surface of a commercial contact lens is modified with nanocomposite composed of levofloxacin and cellulose nanofibrils to create a theranostic contact lens for ocular infection, which the cellulose nanofibril helps improving drug entrapment, wettability and pH-sensitiveness to the pristine contact lens in order to control the releasing amount of levofloxacin depending on infection severity. The developed theranostic contact lens also indicates severity of infection by colorimetric pH sensor. Lastly, fourth part, chitosan is incorporated with developed titanium dioxide/nitrogen-doped graphene nanocomposites to enhance laser-absorbing and desorption property, leading to enhanced ionization efficiency of analytes without using an additional matrix, and utilizes as a novel substrate of LDI-MS for biomolecules determination.

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Theranostic contact lens based on cellulose nanofibrils/levofloxacin nanocomposite for ocular bacterial infection

et al. 2023

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Severe Ocular Bacterial Infections: A Retrospective Study Over 13 Years

Abstract: In vitro susceptibility tests showed that levofloxacin and moxifloxacin (introduced only in 2010) had the highest efficacy against bacterial isolates.

Cited by 5 publications

References 11 publications

Bacteriological profiles and drug susceptibility of Streptococcus isolated from conjunctival sac of healthy children

Bacteriological profiles and drug susceptibility of Streptococcus isolated from conjunctival sac of healthy children

Biopolymer nanocomposites for food and healthcare applications

Theranostic contact lens based on cellulose nanofibrils/levofloxacin nanocomposite for ocular bacterial infection

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