Severe Oxalosis With Systemic Manifestations

Samarneh, Majed; Shtaynberg, Norbert; Goldman, Melvin; Epstein, Edward; Kleiner, Morton; El‐Sayegh, Suzanne

doi:10.4021/jocmr525w

Cited by 4 publications

(3 citation statements)

References 20 publications

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“…Коли швидкість клубочкової фільтрації падає нижче 30-40 мл/хв/1,73 м 2 , елімінація сечі не здатна підтримувати оксалемію в межах нормальних рівнів (<6 мкмоль/л) і поріг насичення оксалатом кальцію може бути перевищений, коли рівні перевищують 30 мкмоль/л, викликаючи відкладення у тканинах у вигляді моногідрату і дигідрату. Це явище називається оксалоз і викликає значну запальну реакцію у вигляді гранульом навколо кристалів [7,83]. Крім того, ЩК є уремічним токсином [84].…”

Section: таблиця 2 продукти з високим вмістом оксалатівunclassified

“…Навмисне або випадкове споживання етиленгліколю, який найчастіше використовується в якості охолоджуючої рідини, може викликати серйозний гіпероксалемічний криз [89]. Токсичність етиленгліколю пов›язана з його біотрансформацією в гліколеву кислоту, що викликає гіпероксалурію і оксалоз [83]. Використання нестероїдних протизапальних препаратів, зокрема при лікуванні остеоартрозу, сприяє загостренню оксалатної нефропатії [90].…”

Section: таблиця 2 продукти з високим вмістом оксалатівunclassified

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Metabolism oxalic acid: failure causes and consequences of molecular-biochemical factors for the formation of oxalate-induced diseases

Korol

Vasylchenko

2019

Ukr. J. Nephrol. and Dial.

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Mechanisms mediating oxalate-induced alterations in renal have attracted the attention of scientists in recent years.Various mechanisms have been proposed to explain crystal retention. The present review assesses the biochemical mechanisms of oxalate-induced alterations and diagnostically significant markers of organ damage caused by oxalate. The article focuses on the modern data of molecular-biochemical aspects of the formation of oxalate-induced diseases.

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Section: таблиця 2 продукти з високим вмістом оксалатівunclassified

Metabolism oxalic acid: failure causes and consequences of molecular-biochemical factors for the formation of oxalate-induced diseases

Korol

Vasylchenko

2019

Ukr. J. Nephrol. and Dial.

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“…Many case studies also note oxalate-induced central nervous system dysfunction without evidence of micro-crystal accumulation in the brain 59 . Oxalate toxicity is associated with damage to the function and structure of nerves 6,[60][61][62][63] .…”

Section: Oxalates Are a Likely Contributor To Many Modern Health Probmentioning

confidence: 99%

Lost Seasonality and Overconsumption of Plants: Risking Oxalate Toxicity

Norton¹

2017

jevohealth

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In many plants, oxalate crystals are present. These relatively large microcrystals have the potential to inflict mechanical injury. On the other hand, ionic, soluble, and nano-crystal forms of oxalate are readily absorbed. Bioaccumulation in humans is well documented. Crystals and ionic oxalate are associated with pain and both functional and chronic disorders. Today's many health challenges have led people to select foods purported to be healthier, many of which are high in oxalate. Modern dietary approaches have placed great emphasis on the health benefits of vegetables, nuts, and spices. Many of these are high oxalate foods that are now distributed through a global food system in which seasons have been erased, making harm from dietary oxalate more likely now than ever before. Lack of awareness of this potential creates fertile ground for continued increases in human suffering and public health problems.

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Sodium Thiosulfate Ameliorates Oxidative Stress and Preserves Renal Function in Hyperoxaluric Rats

et al. 2015

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BackgroundHyperoxaluria causes crystal deposition in the kidney, which leads to oxidative stress and to injury and damage of the renal epithelium. Sodium thiosulfate (STS, Na2S2O3) is an anti-oxidant, which has been used in human medicine for decades. The effect of STS on hyperoxaluria-induced renal damage is not known.MethodsHyperoxaluria and renal injury were induced in healthy male Wistar rats by chronic exposure to ethylene glycol (EG, 0.75%) in the drinking water for 4 weeks. The treatment effects of STS, NaCl or Na2SO4 were compared. Furthermore, the effects of STS on oxalate-induced oxidative stress were investigated in vitro in renal LLC-PK1 cells.ResultsChronic EG exposure led to hyperoxaluria, oxidative stress, calcium oxalate crystalluria and crystal deposition in the kidneys. Whereas all tested compounds significantly reduced crystal load, only STS-treatment maintained tissue superoxide dismutase activity and urine 8-isoprostaglandin levels in vivo and preserved renal function. In in vitro studies, STS showed the ability to scavenge oxalate-induced ROS accumulation dose dependently, reduced cell-released hydrogen peroxide and preserved superoxide dismutase activity. As a mechanism explaining this finding, STS was able to directly inactivate hydrogen peroxide in cell-free experiments.ConclusionsSTS is an antioxidant, which preserves renal function in a chronic EG rat model. Its therapeutic use in oxidative-stress induced renal-failure should be considered.

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Severe Oxalosis With Systemic Manifestations

Cited by 4 publications

References 20 publications

Metabolism oxalic acid: failure causes and consequences of molecular-biochemical factors for the formation of oxalate-induced diseases

Metabolism oxalic acid: failure causes and consequences of molecular-biochemical factors for the formation of oxalate-induced diseases

Lost Seasonality and Overconsumption of Plants: Risking Oxalate Toxicity

Sodium Thiosulfate Ameliorates Oxidative Stress and Preserves Renal Function in Hyperoxaluric Rats

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