Severe Sepsis Attenuates Alveolar Macrophage PPARGamma Activity

Esper, Annette; Kleinhenz, Jennifer M.; Ward, Laura; Brown, Lou Ann S.; Hart, C. Michael; Martin, Grégory

doi:10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a3867

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Specifically, one study was an observational study of patients with severe sepsis or septic shock[6] and the other study was a randomized control trial of albumin vs. hetastarch in patients with acute respiratory distress syndrome (ARDS)[7]. Patients were enrolled from the adult ICUs at Grady Memorial Hospital, Emory University Hospital and Emory University Hospital Midtown from May 2009 to September 2012.…”

Section: Methodsmentioning

confidence: 99%

Safety of research bronchoscopy in critically ill patients

Prebil

Andrews

Cribbs

et al. 2014

Journal of Critical Care

View full text Add to dashboard Cite

Objective Bronchoscopy and bronchoalveolar lavage are common procedures in intensive care units, however no contemporaneous safety and outcomes data have been reported, particularly for critically ill patients. Design Retrospective analysis of prospectively collected data from teaching hospital adult intensive care units. Interventions One hundred mechanically ventilated patients with severe sepsis, septic shock, acute lung injury and/or acute respiratory distress syndrome underwent bronchoscopy with unilateral bronchoalveolar lavage (BAL). Data collected included demographics, presence of sepsis or acute lung injury, PaO2 to FiO2 ratio, PEEP, APACHE score, SOFA score, and peri-procedural or post-procedural complications. Results Men comprised 51% of the patients; 81% of patients were black and 15% were white. The mean age was 52 (SD ± 16) years. The mean APACHE score was 22 (± 7.5) while the median SOFA score was 9 (IQR 5–12). Ten patients (10%) had complications during or immediately after the procedure. Hypoxemia during or immediately after the BAL was the most common complication. 90% of complications were related to transient hypoxemia; while bradycardia and hypotension each occurred in one patient. Age, female gender and higher PEEP were associated with complications. Conclusions Bronchoscopy with BAL in critically ill patients with sepsis and ALI is well tolerated with low risk of complications, primarily related to manageable hypoxemia.

show abstract

Section: Methodsmentioning

confidence: 99%