Severe subcutaneous generalized edema in a patient with dermatomyositis

Ito, Yoshinaga; Kawabata, Daisuke; Yukawa, Naoichiro; Yoshifuji, Hajime; Usui, Takashi; Tanaka, Masao; Fujii, Tomoyuki; Mimori, Tsuneyo

doi:10.1007/s10165-006-0560-9

Cited by 17 publications

(10 citation statements)

References 10 publications

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“…In support of the growing number of cases of EDM, efforts are underway to elucidate the underlying mechanism behind this dramatic third spacing. Recent hypotheses as to the causative process include elevated VEGF expression, 8 increased vascular permeability in an inflammatory state, 9 and elevated serum type I interferon. 6 However, none of these hypotheses have sufficient data delineating differences in the underlying pathogenesis that would distinguish DM from EDM.…”

Section: Discussionmentioning

confidence: 99%

Paraneoplastic Edematous Dermatomyositis: A Rare Syndrome Observed in a Case of Small Cell Lung Cancer

Zarrabi

Choy

Sweeney

et al. 2017

Clinics and Practice

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Dermatomyositis with subcutaneous edema is a rare process with few reported cases. We report a 63-year-old with lung cancer who presented with an erythematous skin rash and was found to have biopsyproven dermatomyositis. Her course was complicated by generalized edema, myalgias, muscle weakness, dysphagia, and laryngeal edema. The edema was severe and caused respiratory distress requiring intubation. The patient underwent therapy with high-dose glucocorticoids and intravenous immunoglobulin but failed treatment. Altogether, she presented as an extreme case and rare variant of dermatomyositis, known as edematous dermatomyositis. Diagnostic and treatment guidelines do not account for this variant and literature pertaining to edematous dermatomyositis is sparse. Moreover, this disease was a paraneoplastic manifestation of her small cell lung cancer, which is rarely observed. There are no cases reporting edematous dermatomyositis as a paraneoplastic manifestation of small cell lung cancer, and we highlight the high rate of morbidity and mortality in such patients.

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Section: Discussionmentioning

confidence: 99%

Paraneoplastic Edematous Dermatomyositis: A Rare Syndrome Observed in a Case of Small Cell Lung Cancer

Zarrabi

Choy

Sweeney

et al. 2017

Clinics and Practice

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“…In our patient, generalized edema was the dominant skin manifestation of dermatomyositis, and generalized edema associated with juvenile dermatomyositis has been reported infrequently in the literature. [10][11][12][13] Our patient also had other skin findings including Gottron's papules and periungual telangiectasia. In most patients, edema begins with the initial manifestation of myopathy; however, it also can be observed with a recurrence of myopathy, as was true with our patient.…”

Section: Discussionmentioning

confidence: 54%

Juvenile Dermatomyositis Presenting With Anasarca

et al. 2008

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Generalized edema can occur during the course of juvenile dermatomyositis. In this article, a 4-year-old boy with generalized nonpitting edema and proximal weakness is reported. Characteristic cutaneous lesions, laboratory tests, results of electromyography, and magnetic resonance imaging findings resulted in a diagnosis of juvenile dermatomyositis. He was treated with corticosteroids and methotrexate. It is concluded that the generalized edema may appear as the presenting cutaneous manifestation of juvenile dermatomyositis.

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“…Thirteen cases received intravenous immunoglobulin. 7,10,[14][15][16][17][18]21,22 Our case received the medium dose of corticosteroid in adjunction with hydroxychloroquine, and the clinical response in resolving localized edema was good.…”

Section: Discussionmentioning

confidence: 99%

Hepatocellular Carcinoma-Associated Polymyositis Presenting With Unilateral Upper Limb Subcutaneous Edema

et al. 2018

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Inflammatory myopathy is characterized by proximal muscle weakness which is highly suspected through an autoimmune pathogenesis. Extramuscular manifestations including fever, arthralgia, and pulmonary complications are common. 1 Diagnosis of both polymyositis (PM) and dermatomyositis (DM) relies on characteristic clinical manifestations, increased serum muscle enzymes, and a standard electromyography (EMG). Periorbital edema is often accompanied by a heliotrope rash. 1 However, subcutaneous edema in limbs is extremely rare. A literature search uncovered 33 cases of limb edema associated with inflammatory myopathy, of whom seven were localized edema, while the remaining were considered generalized edema. All seven patients with localized edema were diagnosed with DM. In this article, we report on a case of PM with localized subcutaneous edema and hepatocellular carcinoma (HCC). To the best of our knowledge, this is the first case of localized edema to be associated with PM.

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Severe subcutaneous generalized edema in a patient with dermatomyositis

Cited by 17 publications

References 10 publications

Paraneoplastic Edematous Dermatomyositis: A Rare Syndrome Observed in a Case of Small Cell Lung Cancer

Paraneoplastic Edematous Dermatomyositis: A Rare Syndrome Observed in a Case of Small Cell Lung Cancer

Juvenile Dermatomyositis Presenting With Anasarca

Hepatocellular Carcinoma-Associated Polymyositis Presenting With Unilateral Upper Limb Subcutaneous Edema

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