Severe thrombocytopenia and agranulocytosis associated with metamizole

García, Pedro L. Fernández; Camacho, María Fernanda Ibáñez; Pérez, Eugenia López

doi:10.1016/j.medcle.2016.11.009

Search citation statements

Order By: Relevance

Paper Sections

Select...

Discussion1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Metamizole can affect hematopoietic cells in terms of an allergic reaction [5][6][7]. This has been described particularly for granulocytes, but an analysis of 161 reports of metamizole-associated agranulocytosis failed to identify individual risk factors [8].…”

Section: Discussionmentioning

confidence: 99%

Case Report: Simultaneously Induced Neutropenia and Hemolysis After a Single Metamizole Dose

et al. 2023

View full text Add to dashboard Cite

Background and objective Metamizole is a non-opioid ampyrone sulfonate compound with potent analgesic, antipyretic, and spasmolytic effects. Agranulocytosis is a rare life-threatening complication of metamizole. Case Here, we present the case of a 62-year-old patient who developed agranulocytosis as well as hemolysis after a single administration of metamizole. Conclusion This case illustrates the inherent allergic potential of metamizole and its effects on different hematopoietic cell types. Key PointsAgranulocytosis and hemolysis occurred simultaneously as a result of the first and single administration of metamizole.It is unclear which individual factors determine the extent of a potential allergic reaction.Patients receiving metamizole for the first time may benefit from a close follow-up, in particular within the first few weeks.

show abstract