Severe visual loss by inhalation of methanol

Figuerola, Belén; Mendoza, Angi; Roca, Montserrat; Lacorzana, Javier

doi:10.22336/rjo.2021.34

Cited by 5 publications

(3 citation statements)

References 6 publications

(6 reference statements)

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“…Metabolic acidosis mainly contributes to systemic toxicity, and ocular effects are thought to be a direct effect of formic acid. Ocular symptoms appear 6-48 h after consumption (6,7) . The main presentation of methanol toxicity is toxic optic neuropathy with or without optic disk and retinal swelling (7) .…”

Section: Discussionmentioning

confidence: 99%

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Novel optical coherence tomography findings in a patient with methanol toxicity: a case report

Işik,

Ersoz,

Dokur

et al. 2025

ABO

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We report a case of acute methanol toxicity with unique optical coherence tomography findings. A 56-year-old man was referred to our ophthalmology clinic with a history of handmade vodka consumption and vision loss. On ophthalmologic examination, his vision was 20/100 in his right eye and 20/200 in his left eye. Bilateral mild optic disk hyperemia was detected on fundus examination. Because of the severity of systemic symptoms in such cases, it is very difficult to include optical coherence tomography in the ophthalmologic examination. However, we managed to perform optical coherence tomography and recorded shallow subretinal fluid and a prominent middle limiting membrane sign as acute retinal structural changes in the patient. The patient was treated with hemodialysis, intravenous ethanol, and sodium bicarbonate. On the fourth day of treatment, visual acuity improved to 20/20 in both eyes. In addition, the prominent middle limiting membrane sign and subretinal fluid disappeared. In this unusual case, retinal pigment epithelium damage and retinal ischemia may have contributed to the prominent middle limiting membrane and subretinal fluid, which are novel optical coherence tomography findings of methanol toxicity.

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Section: Discussionmentioning

confidence: 99%

“…According to some studies, corticosteroids improve the visual function of patients with methanol toxicity; however, the validity of this claim remains questionable (6,10) . We did not include corticosteroids in the treatment of this patient.…”

Section: Discussionmentioning

confidence: 99%

Novel optical coherence tomography findings in a patient with methanol toxicity: a case report

Işik,

Ersoz,

Dokur

et al. 2025

ABO

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show abstract

“…Accidental oral ingestion is the primary exposure route [1,3,[9][10][11]. Inhalation and dermal absorption associated with occupational exposure or intentional abuse have been increasingly reported [8,[12][13][14][15][16][17][18][19]. Methanol intoxication is caused by its metabolite formate, an inhibitory enzyme of the mitochondrial respiratory chain.…”

Section: Introductionmentioning

confidence: 99%

Clinical Characteristics of Methanol-Induced Optic Neuropathy: Correlation between Aetiology and Clinical Findings

Sun

Zhang

et al. 2022

Journal of Ophthalmology

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Purpose. To show the clinical characteristics, identify the magnetic resonance imaging (MRI) and optical coherence tomography (OCT) features, and observe the visual outcome of methanol-induced optic neuropathy. Methods. Clinical data were retrospectively collected from in-patients diagnosed with methanol-induced optic neuropathy in the Neuro-Ophthalmology Department of the Chinese People’s Liberation Army General Hospital from January 2016 to January 2021. Results. Eight patients were included in this study. The exposure time was 6–34 h for ingestion, 3-4 months for inhalation, and more than ten years for skin absorption. All patients demonstrated bilateral acute visual impairment. Seven of eight patients had other accompanying systemic symptoms. Seven of eight patients demonstrated optic nerve lesions in MRI, and five presented with a hyperintense T2 signal in a “central” type. OCT showed the macular ganglion cell layer and inner plexiform layer (mGCL-IPL) thinning before the peripapillary retinal nerve fiber layer (pRNFL) thinning. The visual improvement was achieved transiently for seven of eight patients after treatment. One patient with a mitochondrial DNA mutation maintained a bilateral no-light perception (NLP) from the onset to the last visit. All patients had poor visual prognoses, with either light perception or NLP. Conclusions. Methanol-induced optic neuropathy is a rare bilateral optic neuropathy with a poor visual outcome. A centrally hyperintense T2 signal of the optic nerve is common in methanol-induced optic neuropathy. The thinning of the mGCL-IPL is more sensitive than that of the pRNFL for early diagnosis. A mitochondrial genetic defect may be a predisposing factor for methanol-induced optic neuropathy.

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Maculopapillary Bundle Degeneration in Optic Neuropathies

Lambiri,

Levin

2024

Curr Neurol Neurosci Rep

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Severe visual loss by inhalation of methanol

Cited by 5 publications

References 6 publications

Novel optical coherence tomography findings in a patient with methanol toxicity: a case report

Novel optical coherence tomography findings in a patient with methanol toxicity: a case report

Clinical Characteristics of Methanol-Induced Optic Neuropathy: Correlation between Aetiology and Clinical Findings

Maculopapillary Bundle Degeneration in Optic Neuropathies

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