1994
DOI: 10.1016/s0190-9622(94)70088-5
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Severely atypical medium-sized congenital nevus with widespread satellitosis and placental deposits in a neonate: The problem of congenital melanoma and its simulants

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Cited by 25 publications
(12 citation statements)
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“…These GCMN are commonly associated with benign melanocytic growths within the substance of the lesion, termed ''proliferative nodules'' (PNs).These may be clinically and pathologically confused with MM. [9][10][11][12] In addition to proliferative nodules, GCMN are often associated with ''satellite nevi.'' 13 These are smaller CMN that are present at birth or arise months to years later.…”
Section: Clinical Presentation Key Pointsmentioning
confidence: 99%
See 1 more Smart Citation
“…These GCMN are commonly associated with benign melanocytic growths within the substance of the lesion, termed ''proliferative nodules'' (PNs).These may be clinically and pathologically confused with MM. [9][10][11][12] In addition to proliferative nodules, GCMN are often associated with ''satellite nevi.'' 13 These are smaller CMN that are present at birth or arise months to years later.…”
Section: Clinical Presentation Key Pointsmentioning
confidence: 99%
“…11,64,84,87 Others state the MM cells are sharply demarcated from adjacent CMN cells relative to PN. 12 Immunohistochemistry with various antibodies and comparative genomic hybridization have also been proposed as potential methods for discerning PN from MM. 88,89 Despite the worrisome clinical and histologic findings of PN, most laboratory investigations seem to support their benignity.…”
Section: Histologymentioning
confidence: 99%
“…Other than the 3 patients we describe herein, only 6 other patients have been described. [1][2][3][4][5][6] The nature of the placental deposits in 1 of our patients has been partially described in a prior report by Carroll et al 7 Prior observers [1][2][3][4][5][6] contend that the cells in these cases are benign melanocytes. This entity must be distinguished from the placental infiltration of melanoma cells originating from maternal melanoma [8][9][10] and fetal congenital melanoma.…”
Section: Discussionmentioning
confidence: 72%
“…Additional details of this patient have been described previously. 7 A review of the literature and further characterization of this process provide further support for a benign infiltration of the placenta by melanocytes in this setting and assist in its distinction from malignant melanoma.…”
Section: Commentmentioning
confidence: 86%
“…Neither cellular atypia nor widespread involvement, including lymph nodes and placenta, proves malignancy (Carroll et al, 1994;Hara, 1993). The risk of melanoma in early infancy may have been overestimated by misinterpretation of the histologic findings and extent of the lesions.…”
mentioning
confidence: 99%