Severity of cholestasis and advanced histological stage but not menopausal status are the major risk factors for osteoporosis in primary biliary cirrhosis

Longitudinal evaluation of hepatic osteodystrophy in children and adolescents with chronic cholestatic liver disease

“…These data contrast with in vitro studies demonstrating that serum with hyperbilirubinemia reduced the mitogenic activity of osteoblast-like cells (5). Some clinical studies also showed that osteoporosis is more frequent in cholestatic patients than in non-cholestatic patients with liver disease (18)(19)(20). However, the present data agree with previous clinical and experimental studies that did not detect an association between cholestasis and bone mass loss (21,22).…”

Risk factors for osteoporosis in patients with end-stage liver disease

“…Previous studies have reported that cholestatic liver disease, including primary biliary cirrhosis and primary sclerosing cholangitis are risk factors for osteoporosis (21)(22)(23). However, in the current study, the prevalence of osteoporosis tended to be higher in cholestatic disease than in non-cholestatic disease, although there was no significant difference identified.…”

Systemic abnormalities in liver disease

“…It has been reported that osteoporosis occurs in approximately 20%-30% of patients with PBC [185,186] , and older age and severity of the disease were the main risk factors for osteoporosis [187] . Moreover, there were 2-fold relative increases in the risk of bone fractures in patients with PBC compared with the general population [188] .…”

“…The liver as an organ. In: Guyton Table 3 Drugs that may need to be administered at reduced doses in patients with liver cirrhosis [187] 2968…”