Severity of clinical manifestations and laryngeal exposure difficulty predicted by glossoptosis endoscopic grades in Robin sequence patients

Manica, Denise; Schweiger, Cláudia; Sekine, Leo; Fagondes, Simone Chaves; Gasparin, Marisa; Levy, Deborah Salle; Kuhl, Gabriel; Collares, Marcus Vinícius Martins; Maróstica, Paulo José Cauduro

doi:10.1016/j.ijporl.2016.09.036

Cited by 11 publications

(8 citation statements)

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“…Moreover, such categorization was also applied on a previous study. 10 Continuous variables were described by median and interquartile range (25th to 75th percentiles). Categorical variables were described by absolute number (n) and percentage (%).…”

Section: Discussionmentioning

confidence: 99%

“…As the obstruction of the airway at the tongue base level is the hallmark of RS, its accurate evaluation is essential. Preliminary findings suggest association of endoscopic classifications and clinical manifestation in glossoptosis patients . In the present study, we look at the diagnostic accuracy of these approaches, nested in a prospective cohort, looking deeper at individual performance characteristics of existing airway classification systems.…”

Section: Discussionmentioning

confidence: 99%

“…We have deliberately chosen the grade 3 from Cole et al to be the positive outcome, because it seemed to us that the amount of compromise it described was the only one that unequivocally required an immediate intervention. Moreover, such categorization was also applied on a previous study …”

Section: Methodsmentioning

confidence: 99%

“…However, de Sousa et al evaluated awake patients, as they were not able to reproduce the sleep state. Clinical manifestations associated with these grading scales was also not extensively studied, although preliminary findings suggested an existing association between worse classification grades and more severe clinical manifestations …”

Section: Introductionmentioning

confidence: 99%

“…Clinical manifestations associated with these grading scales was also not extensively studied, although preliminary findings suggested an existing association between worse classification grades and more severe clinical manifestations. 10 The main objective of the present research was to compare current endoscopic grading systems of glossoptosis and ascertain their performance in identifying ominous clinical manifestations. In doing so, we aimed at verifying the utility and accuracy of FFL in this disorder and expand its application in clinical practice.…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic accuracy of current glossoptosis classification systems: A nested cohort cross‐sectional study

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Diagnostic accuracy of current glossoptosis classification systems: A nested cohort cross‐sectional study

et al. 2017

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Predictors of Respiratory Dysfunction at Diagnosis of Robin Sequence

et al. 2021

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Objectives/Hypothesis: Robin sequence (RS) consists of associated micrognathia, glossoptosis, and respiratory dysfunction, with or without cleft palate. Studies on how different patient characteristics impact the severity of respiratory dysfunction are scarce and contradictory; this study investigates how different features affect respiratory obstruction severity at diagnosis of RS in controlled analysis.Study Design: Retrospective cohort study that enrolled 71 RS patients under 90 days old who received care in our institution from 2009 to 2020.Methods: The primary outcome, respiratory dysfunction, was categorized into four severity groups and analyzed using a multinomial logistic regression model that considered age, sex, mandible length, cleft palate, syndromic diagnosis, other airway anomalies, and degree of glossoptosis.Results: Mandible length, syndromic diagnosis, and Yellon grade 3 glossoptosis were related to poorer respiratory outcomes (need for respiratory support). In univariate analysis, for each additional 1 mm of mandible length at diagnosis, a mean reduction of 28% in the risk of needing respiratory support was observed (OR = 0.72; 0.58-0.89); syndromic diagnosis and grade 3 glossoptosis also raised the risk (OR = 6.50; 1. respectively). In multivariate analysis, only mandible length significantly maintained its effects (OR = 0.73; 0.56-0.96), a 27% reduction.Conclusions: Mandible length was an independent predictor for more severe respiratory dysfunction in RS patients, with larger mandibles showing protective effects. Syndromic diagnosis and Yellon grade 3 glossoptosis are also likely to be associated with poorer respiratory outcomes, although this was not demonstrated in multivariate analysis.

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