Severity of COPD and its relationship with IL-10

Silva, Bruna S A; Lira, Fábio Santos; Ramos, Dionei; Uzeloto, Juliana Souza; Rossi, Fabrí­cio Eduardo; Freire, Ana Paula Coelho Figueira; Silva, Rebeca N.; Trevisan, Iara Buriola; Gobbo, Luís Alberto

doi:10.1016/j.cyto.2017.10.018

Cited by 48 publications

(36 citation statements)

References 43 publications

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“…Few studies have investigated the role of IL-10 in the systemic inflammation of people with COPD. Similar to our results, recent studies have demonstrated that COPD people show reduced plasma levels [ 30 , 31 ]. Interleukin-10 has been shown to suppress all the proinflammatory cytokines and is effective in blocking the synthesis of IL-8 [ 32 ].…”

Section: Discussionsupporting

confidence: 93%

Acute Effects of Whole-Body Vibration on Inflammatory Markers in People with Chronic Obstructive Pulmonary Disease: A Pilot Study

Lage

Lacerda

Neves

et al. 2018

Rehabilitation Research and Practice

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Whole-body vibration (WBV) has gained prominence in the rehabilitation of individuals with chronic obstructive pulmonary disease (COPD) because it is a safe and low intensity exercise that promises beneficial effects on physical performance and quality of life. However, its effects on plasma cytokine levels in COPD are still unclear. The aim of the current study was to investigate the acute effects of WBV on inflammatory biomarkers in people with COPD. Twenty-six participants, COPD people (n=13) and healthy controls (n=13), were included. Both groups performed WBV at amplitude of 2 mm and frequency of vibration of 35 Hz, during six series of 30 seconds. They were assessed for lung function, body composition, 6-minute walking test (6MWT), handgrip strength test, plasma concentrations of interleukin (IL), IL-6, IL-8, and IL-10, and soluble tumor necrosis factor alpha (TNF-α) receptors (sTNFR-1 and sTNFR-2). People with COPD had moderate disease [forced expiratory volume in the first second (FEV1) = 58.1%], as well as a worse performance in the 6MWT. The plasma cytokine profile at rest showed that participants with COPD had higher levels of IL-8 and lower levels of IL-10. After one session of WBV, we found an increased plasma IL-10 level in the COPD group, with similar levels for healthy controls. One session of WBV modified the plasma IL-10 level. No effects were found on the other investigated cytokines.

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Section: Discussionsupporting

confidence: 93%

Acute Effects of Whole-Body Vibration on Inflammatory Markers in People with Chronic Obstructive Pulmonary Disease: A Pilot Study

Lage

Lacerda

Neves

et al. 2018

Rehabilitation Research and Practice

View full text Add to dashboard Cite

show abstract

“…31,32 Furthermore, many studies have explored the association of cytokines with the lung function of patients with stable COPD. 30,[33][34][35] Previous studies have shown correlations between plasma levels of TNF-α, IL-1β, IL-6, IL-10, IL-15, and IL-17 with the severity of bronchial obstruction. [33][34][35] Bradford et al, in a combined analysis of two large studies, including 2123 subjects from "COPDGene" and 1117 subjects from "SPIROMICS", with analysis of six cytokines (IL-2, IL-6, IL-8, IL-10, TNF-α, and IFN-γ), found an association of four biomarkers (IL-6, IL-8, and IL-10) with worse airflow obstruction.…”

Section: Discussionmentioning

confidence: 99%

<p>Systemic Cytokine Profiles of CD4+ T Lymphocytes Correlate with Clinical Features and Functional Status in Stable COPD</p>

Uzeloto

Toledo-Arruda

Silva

et al. 2020

COPD

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“…An increase in the serum level of IL-10 can reduce the effects of various inflammatory factors, such as IL-6 and IL-8, and further inhibit the airway inflammatory response and airway secretions, thereby improving the ventilation function. 33 , 34 IL-35 exerts a certain inhibitory effect on inflammatory response, and it also negatively regulates the activity of immune factors, thereby improving the lung function of patients. 35 Another study suggested that IL-35 plays a role in retarding the pathogenesis of COPD by regulating the inflammatory response of Th2- and Th17-mediated COPD.…”

Section: Discussionmentioning

confidence: 99%

Increased serum IL-17 and decreased serum IL-10 and IL-35 levels correlate with the progression of COPD

Jiang¹,

Zhang²,

Jiang³

et al. 2018

COPD

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PurposeThis study aimed to measure the serum levels of interleukin (IL)-17, IL-10, and IL-35 in patients with stable chronic obstructive pulmonary disease (COPD) and disclose the correlations between their expression levels and clinical factors of patients.MethodsA total of 75 patients with stable COPD (47 males and 28 females) and 30 healthy controls (15 males and 15 females) were included in this study. The serum levels of IL-17, IL-10, and IL-35 were determined by enzyme-linked immunosorbent assay. The correlations between their expression levels and clinical factors of patients were determined using linear regression methods.ResultsThe serum level of IL-17 was upregulated in stable COPD, and increased IL-17 expression was positively correlated with the Global Initiative for Chronic Obstructive Lung Disease (GOLD) grading, modified Medical Research Council (mMRC) score, and long clinical history (P<0.05), but negatively correlated with the pulmonary function (P<0.05) of patients. The serum levels of IL-10 and IL-35 were downregulated in stable COPD, and decreased IL-10 and IL-35 levels negatively correlated with the smoking status, GOLD grading, mMRC score, and long clinical history (P<0.05), but positively correlated with the pulmonary function (P<0.05) of patients. Moreover, the level of IL-17 negatively correlated with IL-10 and IL-35, but IL-10 positively correlated with IL-35.ConclusionThe serum levels of IL-17, IL-10, and IL-35 correlated with the clinical factors of COPD, indicating that they can serve as indicators to estimate the progression of COPD.

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Severity of COPD and its relationship with IL-10

Abstract: Our findings suggest that patients with severe COPD can exhibit compromised "inflammatory status", characterized by higher IL6, IL-6/IL-10 ratio and lower IL-10 concentration. Furthermore, IL-10 seems to be an interesting cytokine to be investigated in this kind of patients.

Cited by 48 publications

References 43 publications

Acute Effects of Whole-Body Vibration on Inflammatory Markers in People with Chronic Obstructive Pulmonary Disease: A Pilot Study

Acute Effects of Whole-Body Vibration on Inflammatory Markers in People with Chronic Obstructive Pulmonary Disease: A Pilot Study

<p>Systemic Cytokine Profiles of CD4+ T Lymphocytes Correlate with Clinical Features and Functional Status in Stable COPD</p>

Increased serum IL-17 and decreased serum IL-10 and IL-35 levels correlate with the progression of COPD

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