Sevoflurane and emergence behavioral changes in pediatrics

Moos, Daniel D.

doi:10.1016/j.jopan.2004.11.008

Cited by 16 publications

(10 citation statements)

References 24 publications

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“…In several studies agitation has been reported in people after anesthesia (29,30); however, Matthews et al (31) reported no complications in various animal species such as horse. Likewise, we did not find such complications in Angora goats.…”

Section: Discussionmentioning

confidence: 99%

Comparison of sevoflurane and isoflurane effects on cardiovascular andrespiratory system during spontaneous ventilation in Angora goats

Kumandaş¹,

Elma²

2015

Turk J Vet Anim Sci

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IntroductionIsoflurane and sevoflurane are noncombustible halogenated anesthetic agents. In addition to a faster anesthesia induction and shorter recovery time, isoflurane also provides good muscle relaxation. Sevoflurane is more preferable than isoflurane because it has lower irritation of the respiratory tract than isoflurane and it has some advantages such as easy induction and a fast recovery compared to isoflurane (1-3).Propofol, a nonbarbiturate derivative, is a sedative and hypnotic drug that can be used in small animals for anesthesia and maintenance of sedation. Due to its shorter half-life and absence of accumulation in the body (4-6), it can be used safely in animals such as small ruminants (4,7). Information of the possible side effects of these types of anesthetics on small ruminants, however, is not present yet (8)(9)(10)(11)(12).Goats are preferred as an animal model in experimental studies such as orthopedic, cardiovascular, respiratory, and cerebrovascular studies (13-15). Sevoflurane, isoflurane, and halothane are often used as anesthetic agents. However, anesthetic requirements have not been determined in the goat for these agents accurately. Therefore, the aim of this research was to compare the anesthetic effects of two different inhalation anesthetics that are used in the maintenance of anesthesia with propofol medication. Materials and methodsThe study was approved by the Animal Research Local Ethics Committee of Kırıkkale University (Decision No: 70/09). Seven healthy adult female Angora goats were used in this study. Prestudy screening included a physical examination and complete blood count to ensure animals were in good health. The same goats were used for both anesthesia groups within a 2-week interval. Once anesthesia was induced with propofol, it was maintained either with isoflurane or sevoflurane.Feed and water were withheld from animals 18 h and 2 h prior to anesthesia respectively in order to prevent ruminal tympani during anesthesia. The medial auricular artery was catheterized (Wellcath-x plus 22G, Vellmed, Turkey) to measured systolic arterial pressure (SAP), diastolic arterial pressure (DAP), and mean arterial pressure (MAP). The caudal auricular vein was Abstract: Seven healthy Angora goats were used to compare the effects of isoflurane and sevoflurane on the cardiovascular and respiratory systems during anesthesia periods. Once anesthesia was induced with propofol at 5.1 ± 0.9 mg/kg, it was maintained with isoflurane at 1%-3% in the first treatment period and sevoflurane at 2%-4% in the second treatment period after a 15-day interval. Heart rates measured immediately after anesthesia induction and 5 min later were found to be statistically significant between anesthetic groups (P < 0.05). Mean blood pressure in the isoflurane group decreased (75.7 ± 7.2 to 59.8 ± 9.8 mmHg) (P < 0.05) throughout the anesthesia period. It was determined that respiratory rate in sevoflurane treatment was lower than that in isoflurane treatment. In terms of time to stand up, sevoflurane-adminis...

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Section: Discussionmentioning

confidence: 99%

Comparison of sevoflurane and isoflurane effects on cardiovascular andrespiratory system during spontaneous ventilation in Angora goats

Kumandaş¹,

Elma²

2015

Turk J Vet Anim Sci

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“…Both desflurane and sevoflurane have been associated with a higher rate of emergence agitation than halothane. 43 Welborn et al 25 reported a 55% rate of emergence agitation with desflurane, whereas Aono et al 44 reported a rate of 40% among preschool boys given sevoflurane.…”

Section: Respiratory Effectsmentioning

confidence: 99%

Inhaled anesthetic agents

Stachnik

2006

American Journal of Health-System Pharmacy

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The inhaled anesthetics have been shown to be both safe and effective in inducing and maintaining anesthesia. These agents differ in potency, adverse-effect profile, and cost. Newer anesthetic gases, such as sevoflurane and desflurane, appear to have more favorable physico-chemical properties. These factors, as well as patient characteristics and duration and type of procedure, must be considered when selecting an inhaled anesthetic.

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“…By maintaining nitrous oxide after the discontinuation of sevoflurane, the concentration of the latter decreased while hypnosis was maintained, thereby the incidence of emergence agitation decreased in comparison to a second group in which nitrous oxide and sevoflurane were discontinued concomitantly. Therefore, emergence agitation could be related to the intrinsic effects of sevoflurane [32]. Cohen et al [29] speculated that a variable rate of neurologic recovery from sevoflurane resulting in a dissociative state may increase the sensitivity and the reactivity of children to their environment.…”

Section: Rapid Awakening In a Hostile Environmentmentioning

confidence: 99%