Sevoflurane downregulates interleukin-6 and interleukin-8 levels in patients after cardiopulmonary bypass surgery: a meta-analysis

Yu, Qing; Li, H M; Li, L L; Wang, S Y; Wu, Yue

doi:10.4238/2015.december.29.9

Cited by 11 publications

(7 citation statements)

References 35 publications

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“…KCNK2 (potassium channel subfamily K member 2) is targeted by five inhalational anesthetic agents. These agents have antiinflammatory effects both systemically 61 and in the lungs 62 and meta-analysis of clinical studies shows protection against pulmonary complications after cardiac surgery 63 . A recent trial suggested that one of these inhalation agents, sevoflurane, offers promise for reducing epithelial injury and improving outcomes in patients with acute respiratory distress syndrome 64 .…”

Section: Discussionmentioning

confidence: 99%

Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function

Wyss¹,

Sofer²,

Lee³

et al. 2018

Nat Commun

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Nearly 100 loci have been identified for pulmonary function, almost exclusively in studies of European ancestry populations. We extend previous research by meta-analyzing genome-wide association studies of 1000 Genomes imputed variants in relation to pulmonary function in a multiethnic population of 90,715 individuals of European (N = 60,552), African (N = 8429), Asian (N = 9959), and Hispanic/Latino (N = 11,775) ethnicities. We identify over 50 additional loci at genome-wide significance in ancestry-specific or multiethnic meta-analyses. Using recent fine-mapping methods incorporating functional annotation, gene expression, and differences in linkage disequilibrium between ethnicities, we further shed light on potential causal variants and genes at known and newly identified loci. Several of the novel genes encode proteins with predicted or established drug targets, including KCNK2 and CDK12. Our study highlights the utility of multiethnic and integrative genomics approaches to extend existing knowledge of the genetics of lung function and clinical relevance of implicated loci.

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Section: Discussionmentioning

confidence: 99%

Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function

Wyss¹,

Sofer²,

Lee³

et al. 2018

Nat Commun

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“…However, in all of these reports, rats received sevoflurane treatment as early as 2 h after the onset of LPS challenge for another 4 h; time dependent effects of sevoflurane treatment were not examined. Interestingly, a recent meta-analysis of patients who underwent cardiopulmonary bypass showed that serum levels of the pro-inflammatory cytokines IL-6 and IL-8 were significantly decreased in sevoflurane pre- and posttreated patients [ 20 ], supporting the notion that sevoflurane anesthesia inhibits the inflammatory response. In this regard our results add to these findings and show that sevoflurane posttreatment promptly prevents inflammation and oxidative responses, but inhibits lung injury in a time dependent manner during mechanical ventilation.…”

Section: Discussionmentioning

confidence: 99%

“…Because many injurious events take place before treatment is available, from a clinical aspect, it would be interesting to know whether inhaled anesthetics act protectively when applied ex post. In fact, the organ-protective effects of sevoflurane or isoflurane posttreatment were demonstrated for patients receiving a cardiopulmonary bypass [ 20 ], as well as for several other experimental injury models [ 14 , 15 , 21 – 26 ]. For instance, sevoflurane posttreatment protected rats from cerebral ischemia-reperfusion injury [ 14 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Sevoflurane posttreatment prevents oxidative and inflammatory injury in ventilator-induced lung injury

et al. 2018

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Mechanical ventilation is a life-saving clinical treatment but it can induce or aggravate lung injury. New therapeutic strategies, aimed at reducing the negative effects of mechanical ventilation such as excessive production of reactive oxygen species, release of pro-inflammatory cytokines, and transmigration as well as activation of neutrophil cells, are needed to improve the clinical outcome of ventilated patients. Though the inhaled anesthetic sevoflurane is known to exert organ-protective effects, little is known about the potential of sevoflurane therapy in ventilator-induced lung injury. This study focused on the effects of delayed sevoflurane application in mechanically ventilated C57BL/6N mice. Lung function, lung injury, oxidative stress, and inflammatory parameters were analyzed and compared between non-ventilated and ventilated groups with or without sevoflurane anesthesia. Mechanical ventilation led to a substantial induction of lung injury, reactive oxygen species production, pro-inflammatory cytokine release, and neutrophil influx. In contrast, sevoflurane posttreatment time dependently reduced histological signs of lung injury. Most interestingly, increased production of reactive oxygen species was clearly inhibited in all sevoflurane posttreatment groups. Likewise, the release of the pro-inflammatory cytokines interleukin-1β and MIP-1β and neutrophil transmigration were completely prevented by sevoflurane independent of the onset of sevoflurane administration. In conclusion, sevoflurane posttreatment time dependently limits lung injury, and oxidative and pro-inflammatory responses are clearly prevented by sevoflurane irrespective of the onset of posttreatment. These findings underline the therapeutic potential of sevoflurane treatment in ventilator-induced lung injury.

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“…Finally, sevoflurane administration may reduce inflammatory markers. In a recent meta-analysis of patients undergoing coronary artery bypass grafting (CABG) surgery, sevoflurane pretreatment significantly reduced concentrations of the pro-inflammatory cytokines interleukin (IL)-6 and IL-8 compared with controls [ 79 ].…”

Section: Emerging Topics In Inhalation Anesthesiamentioning

confidence: 99%

A clinical review of inhalation anesthesia with sevoflurane: from early research to emerging topics

et al. 2017

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A large number of studies during the past two decades have demonstrated the efficacy and safety of sevoflurane across patient populations. Clinical researchers have also investigated the effects of sevoflurane, its hemodynamic characteristics, its potential protective effects on several organ systems, and the incidence of delirium and cognitive deficiency. This review examines the clinical profiles of sevoflurane and other anesthetic agents, and focuses upon emerging topics such as organ protection, postoperative cognitive deficiency and delirium, and novel ways to improve postanesthesia outcomes.

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Sevoflurane downregulates interleukin-6 and interleukin-8 levels in patients after cardiopulmonary bypass surgery: a meta-analysis

Cited by 11 publications

References 35 publications

Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function

Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function

Sevoflurane posttreatment prevents oxidative and inflammatory injury in ventilator-induced lung injury

A clinical review of inhalation anesthesia with sevoflurane: from early research to emerging topics

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