Sevoflurane-induced cognitive decline in aged mice: Involvement of toll-like receptors 4

Fei, Xiang; Wu, Yao; Dong, Ning; Zhang, Sheng

doi:10.1016/j.brainresbull.2020.08.030

Cited by 14 publications

(7 citation statements)

References 33 publications

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“…It is a classic method for evaluating long-term spatial learning and memory in rodents (Tian et al, 2019). The results of the water maze spatial exploration experiment showed that, after sevoflurane anesthesia treatment, the number of platform crossing was significantly decreased in the NS group compared to the NC group, demonstrating that sevoflurane anesthesia caused some impairment of cognitive function in aged mice, which is consistent with previous findings (Fei et al, 2020;. And when comparing aged mice with different VD levels after sevoflurane anesthesia, it was found that VD (+) aged mice were significantly better than the NS and VD (-) groups, demonstrating that high serum levels of VD could reduce the cognitive impairment caused by sevoflurane.…”

Section: Discussionsupporting

confidence: 90%

Post-Operative Neuropsychiatric Disorder

2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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Section: Discussionsupporting

confidence: 90%

Post-Operative Neuropsychiatric Disorder

2024

Frontiers Research Topics

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“…It is a classic method for evaluating long-term spatial learning and memory in rodents (Tian et al, 2019). The results of the water maze spatial exploration experiment showed that, after sevoflurane anesthesia treatment, the number of platform crossing was significantly decreased in the NS group compared to the NC group, demonstrating that sevoflurane anesthesia caused some impairment of cognitive function in aged mice, which is consistent with previous findings (Fei et al, 2020;Wang et al, 2021). And when comparing aged mice with different VD levels after sevoflurane anesthesia, it was found that VD (+) aged mice were significantly better than the NS and VD (-) groups, demonstrating that high serum levels of VD could reduce the cognitive impairment caused by sevoflurane.…”

Section: Discussionsupporting

confidence: 90%

Effect of Different Vitamin D Levels on Cognitive Function in Aged Mice After Sevoflurane Anesthesia

Zhang

Yang

Zhao

et al. 2022

Front. Aging Neurosci.

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Although the biological relationship between vitamin D (VD) deficiency and cognitive function has been recognized by many scholars, the theoretical mechanisms involved are still not well-understood. In this study, we demonstrated the role of VD in alleviating the cognitive dysfunction in aged mice caused by sevoflurane anesthesia. Forty female C57BL/6 mice aged 12 months were selected for the experiment. VD (-) and VD (+) mouse models and sevoflurane anesthesia models were established. Mice were randomly divided into normal elderly group (NC group), normal aged mice + sevoflurane anesthesia treatment group (NS group), aged VD (-) mice + sevoflurane anesthesia treatment group [VD (-) group], and aged VD (+) + sevoflurane anesthesia treatment group [VD (+) group]. To compare the emergence time after sevoflurane anesthesia in aged mice with different levels of VD and to test the cognitive function of four groups through the water maze. Inflammatory factor expression and cholinergic activity in hippocampus tissue of all mice were measured at the end of behavioral tests. These data show that, low levels of VD aggravated the delayed emergence and cognitive dysfunction in aged mice caused by sevoflurane anesthesia, while higher levels of VD mitigated this impairment by enhancing cholinergic activity and reducing inflammatory factor expression in the hippocampus.

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“…Published literature suggested that anesthetic exposure to the young and aged animals caused learning and memory disabilities ( Dai et al, 2020 ; Fei et al, 2020 ; Zheng et al, 2020 ). In general, adult age animals are resistant to anesthetics-induced neuronal injury although the mechanisms responsible for this difference are unknown.…”

Section: Discussionmentioning

confidence: 99%

TRPV1 Antagonist Prevents Neonatal Sevoflurane-Induced Synaptic Abnormality and Cognitive Impairment in Mice Through Regulating the Src/Cofilin Signaling Pathway

Liu

Han

et al. 2021

Front. Cell Dev. Biol.

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Long-term neurodevelopmental disorders following neonatal anesthesia have been reported both in young animals and in children. The activation of transient receptor potential vanilloid 1 (TRPV1) channels in hippocampus adversely affects neurodevelopment. The current study explored the underlying mechanism of TRPV1 channels on long-lasting cognitive dysfunction induced by anesthetic exposure to the developing brain. we demonstrated that TRPV1 expression was increased after sevoflurane exposure both in vitro and in vivo. Sevoflurane exposure to hippocampal neurons decreased the synaptic density and the surface GluA1 expression, as well as increased co-localization of internalized AMPAR in early and recycling endosomes. Sevoflurane exposure to newborn mice impaired learning and memory in adulthood, and reduced AMPAR subunit GluA1, 2 and 3 expressions in the crude synaptosomal fractions from mouse hippocampus. The inhibition of TRPV1 reversed the phenotypic changes induced by sevoflurane. Moreover, sevoflurane exposure increased Src phosphorylation at tyrosine 416 site thereby reducing cofilin phosphorylation. TRPV1 blockade reversed these suppressive effects of sevoflurane. Our data suggested that TRPV1 antagonist may protect against synaptic damage and cognitive dysfunction induced by sevoflurane exposure during the brain developing stage.

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Sevoflurane-induced cognitive decline in aged mice: Involvement of toll-like receptors 4

Cited by 14 publications

References 33 publications

Post-Operative Neuropsychiatric Disorder

Post-Operative Neuropsychiatric Disorder

Effect of Different Vitamin D Levels on Cognitive Function in Aged Mice After Sevoflurane Anesthesia

TRPV1 Antagonist Prevents Neonatal Sevoflurane-Induced Synaptic Abnormality and Cognitive Impairment in Mice Through Regulating the Src/Cofilin Signaling Pathway

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