Sevoflurane promotes the expansion of glioma stem cells through activation of hypoxia-inducible factors in vitro

Abstract

Sevoflurane can promote the expansion of human GSCs through HIFs in vitro. Inhaled anaesthetics may enhance tumour growth through tumour stem cells.

Isoflurane enhances the malignant potential of glioblastoma stem cells by promoting their viability, mobility in vitro and migratory capacity in vivo

“…34 Sevoflurane has also been reported to promote expansion of glioma stem cells through activation of HIFs. 35 In concordance with these findings, we found in vitro migration of U251-GSCs pre-exposed in vivo to isoflurane was significantly greater and the migrated distance was increased.…”

Sevoflurane suppresses hypoxia-induced growth and metastasis of lung cancer cells via inhibiting hypoxia-inducible factor-1α

“…These results indicated that the inhibiting effects of sevoflurane on hypoxia-induced growth and metastasis of lung cancer cells might be through down-regulating HIF-1α protein level. However, sevoflurane has been reported to promote the expansion of glioma stem cells under normoxic conditions by up-regulating HIF-1α [22]. Sun et al found that sevoflurane preconditioning produces protective effects on survival and migration of bone marrow mesenchymal stem cells against hypoxia by up-regulating HIF-1α [23].…”

Inhalational Anesthetic Agents and Their Effects on Cancer Cell Biology

“…Pathway inhibitors (labeled in red) include PD98059, wortmannin, LY294002, and the tumor suppressor PTEN (Color figure online) the key involvement of PI3K, ERK 1/2, mitochondrial ATP-potassium channels, and mitochondrial permeability transition pore (mPTP) in reducing myocardial infarct size and myocyte apoptosis during early reperfusion by sevoflurane postconditioning. There has also been a recent report of sevoflurane-induced expansion of human glioma stem cells, with corresponding rises in HIF-1a, HIF-2a, p-AKT, and VEGF [50].…”

“…Similarly, sevoflurane exposure enhanced proliferation of glioma stem cells, a finding which was reversed by the administration of small interfering RNA against HIFs [50].…”