2020
DOI: 10.1101/2020.06.26.20139063
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Sex, age, and hospitalization drive antibody responses in a COVID-19 convalescent plasma donor population

Abstract: Convalescent plasma is currently one of the leading treatments for COVID-19, but there is a paucity of data identifying therapeutic efficacy. A comprehensive analysis of the antibody responses in potential plasma donors and an understanding of the clinical and demographic factors that drive variant antibody responses is needed. Among 126 potential convalescent plasma donors, the humoral immune response was evaluated by a SARS-CoV-2 virus neutralization assay using Vero-E6-TMPRSS2 cells, commercial IgG and IgA … Show more

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Cited by 180 publications
(306 citation statements)
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“…Similarly, a recent study demonstrated neutralizing titers at <1:50 in 33% of recovered patients and below 1:1000 in 79% of Tang 13 patients (23). Our findings are also consistent with a study assessing the agreement between the EI IgG result and neutralizing titers on predominantly non-hospitalized convalescent plasma donors (33). The authors demonstrated that at a neutralizing titer of 1:320, the PPA and NPA were 96% and 32% respectively and that neutralizing titers were higher in a small cohort of hospitalized patients.…”
Section: Discussionsupporting
confidence: 92%
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“…Similarly, a recent study demonstrated neutralizing titers at <1:50 in 33% of recovered patients and below 1:1000 in 79% of Tang 13 patients (23). Our findings are also consistent with a study assessing the agreement between the EI IgG result and neutralizing titers on predominantly non-hospitalized convalescent plasma donors (33). The authors demonstrated that at a neutralizing titer of 1:320, the PPA and NPA were 96% and 32% respectively and that neutralizing titers were higher in a small cohort of hospitalized patients.…”
Section: Discussionsupporting
confidence: 92%
“…Here, we observed that higher neutralizing titers are associated with worse clinical outcomes, a finding that was not observed with commercial serological assays. While seemingly counterintuitive, it is consistent with previous literature and may be a result of higher antigen burdens or hyperactive immune responses among other reasons (30)(31)(32)(33)(34). A study of service members in the US Navy with predominantly mild symptoms revealed that ~40% of those with a positive ELISA by the CDC assay had no neutralizing titers at a cutoff of 1:40 (35).…”
Section: Discussionsupporting
confidence: 86%
“…phenotype) SARS-CoV-2-specific T cells ex vivo (Figure 1A). A total of 30 convalescent plasma donors (confirmed by PCR at time of infection) with HLA-A*01:01, HLA-A*02:01, HLA-A03:01, HLA-A*11:01, HLA-A*24:02 and HLA-B*07:02 alleles were evaluated 3 . The individuals included 18 males and 12 females ranging between 19 and 77 years old, and were a median of 42.5 days (interquartile range 37.5-48.0) from initial diagnosis (Table S1).…”
Section: Resultsmentioning
confidence: 99%
“…not having been pregnant within the six weeks prior to donation, no history or socio-behavioural risk factors for the major transfusion transmissible infections e.g. HIV, hepatitis B and C) 3 . Eligible individuals were enrolled in the study under full, written informed consent, after which whole blood (25 mL) samples were collected.…”
Section: Methodsmentioning
confidence: 99%
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