Sex- and age-specific associations between major depressive disorder and metabolic syndrome in two general population samples in Germany

Block, Andrea; Schipf, Sabine; Auwera, Sandra Van der; Hannemann, Anke; Nauck, Matthias; John, Ulrich; Völzke, Henry; Freyberger, Harald J.; Dörr, Marcus; Felix, Stephan B.; Zygmunt, Marek; Wallaschofski, Henri; Grabe, Hans J.

doi:10.1080/08039488.2016.1191535

Cited by 23 publications

(21 citation statements)

References 65 publications

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“…The potential mechanism might be related to its co-occurrence with obesity [6], as obesity is an important component of MetS and visceral adipose tissue secretes inflammatory cytokines that could cause chronic inflammation, and trigger MetS [7][8][9]. In addition, gender may be an effect modifier in the relationship between depression or depressive symptoms and MetS, even though studies reported inconsistent findings regarding the moderation effect of gender on the association between depression and MetS [10][11][12]. For example, a longitudinal study in Europe indicated that women Page 2 of 7 Liu et al Diabetol Metab Syndr (2020) 12:18 but not men with depressive symptoms are vulnerable to MetS [10,11].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, gender may be an effect modifier in the relationship between depression or depressive symptoms and MetS, even though studies reported inconsistent findings regarding the moderation effect of gender on the association between depression and MetS [10][11][12]. For example, a longitudinal study in Europe indicated that women Page 2 of 7 Liu et al Diabetol Metab Syndr (2020) 12:18 but not men with depressive symptoms are vulnerable to MetS [10,11]. On the contrary, a study from Japan found that the association only presented in men [12].…”

Section: Introductionmentioning

confidence: 99%

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Depressive symptoms and metabolic syndrome components among older Chinese adults

Liu

Qian

Ma³

et al. 2020

Diabetol Metab Syndr

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Background: Few studies examined associations between depressive symptoms and metabolic syndrome (MetS) among older Chinese adults. Considering that the prevalence of depressive symptoms is high in older Chinese adults, we aimed to examine associations of depressive symptoms with MetS and its components in older Chinese adults.Methods: Data from a community-based cross-sectional study of 4579 Chinese adults aged 60 years or older were analyzed. Depressive symptoms were assessed using the nine-item Patient Health Questionnaire. The presence of MetS was defined based on the Adult Treatment Panel III criteria, which include obesity, reduced blood high-density lipoprotein, high blood pressure (BP), elevated fasting plasma glucose and hypertriglyceridemia. A participant was considered as having MetS if he or she met at least three of the above-mentioned criteria.Results: In all participants, depressive symptoms were related to elevated fasting plasma glucose (≥ 7.0 mmol/L) (adjusted odds ratio [OR] = 1.50, 95% confidence interval [CI] [1.00-2.20]) and diabetes (adjusted OR = 1.50, 95% CI [1.01-2.20]). The associations of depressive symptoms with MetS and its components were not significant among women. However, there was a negative association between depressive symptoms and elevated systolic BP (≥ 130 mm Hg) (OR = 0.59, 95% CI [0.4-0.9]), and similar findings were observed after adjusting for lifestyle-related variables in men. Conclusions:In older Chinese adults, depressive symptoms were negatively associated with elevated systolic BP in men while these findings were not found in women.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Depressive symptoms and metabolic syndrome components among older Chinese adults

Liu

Qian

Ma³

et al. 2020

Diabetol Metab Syndr

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“…Метаболический синдром широко распространен и в развитых, и в развивающихся странах. Так, в США этот синдром встречается у 33% взрослого населения [3], в Германии -у 19,4% женщин и 30,2% мужчин [4]. В Бразилии это нарушение обмена веществ отмечается у 29,6% жителей [5], на урбанизированных территориях Индии -у 23,2% населения (по данным ВОЗ) [6].…”

Section: актуальностьunclassified

The Role of Reactive Oxygen Species in the Pathogenesis of Adipocyte Dysfunction in Metabolic Syndrome. Prospects of Pharmacological Correction

Прокудина¹,

Maslov²,

Ivanov³

et al. 2017

Annals RAMS

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It is established that oxidative stress induces insulin resistance of adipocytes, increases secretion leptin, IL-6, TNF-α by adipocytes. Adiponectin secretion by adipocytes is reduced after the action of reactive oxygen species. Metabolic syndrome contributes to oxidative stress in adipose tissue, on the one hand due to the activation of production of reactive oxygen species by adipocyte NADPH-oxidase, and on the other hand by reducing the antioxidant defense adipocytes. It is found that obesity itself can induce oxidative stress. Chronic stress, glucocorticoids, mineralocorticoids, angiotensin-II, TNF-α play an important role in the pathogenesis of oxidative stress of adipocytes. Metformin remains the cure for the treatment of insulin resistance. The positive results in the treatment of metabolic syndrome by losartan were obtained. Antioxidants and flavonoids exhibit a positive impact on the course of the experimental metabolic syndrome.

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“…Despite the increasing MetS prevalence among patients with serious mental illness, the associated results have been inconsistent (Block et al . ; Chen et al . ).…”

Section: Introductionmentioning

confidence: 99%

“…Despite the increasing MetS prevalence among patients with serious mental illness, the associated results have been inconsistent (Block et al 2016;Chen et al 2016). In addition, the prevalence of MetS and its components differ based on gender and age (Vincenzi & Henderson, 2018).…”

Section: Introductionmentioning

confidence: 99%

Gender differences in metabolic syndrome risk factors among patients with serious mental illness

Tzeng

Chiang

Feng

et al. 2019

Int J Mental Health Nurs

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The prevalence of metabolic syndrome and its components continue to increase among patients with serious mental illness. This cross‐sectional study investigated whether metabolic syndrome prevalence and risk factors differ between male and female patients with serious mental illness. In total, 260 eligible patients were recruited from two hospitals. The data on demographic characteristics, lifestyle behaviour factors, biochemistry, and anthropometry were collected. Analyses were performed using multivariate logistic regression. Metabolic syndrome prevalence was 40.8% (35.1% in men and 46.8% in women). Among patients aged 40–49 years, metabolic syndrome prevalence was higher in men; however, the trend was reversed among patients aged 50 years or older. Notably, gender‐specific metabolic syndrome risk factors were observed. In men, they included low education level, high body mass index (BMI), prolonged illness, comorbid physical illness, and diagnosis of bipolar disorder, whereas they included being married, old age, and high BMI in women. Our findings suggest that mental health professionals should consider the gender‐ and age‐based metabolic syndrome prevalence trend in patients with serious mental illness when designing interventions for the study population to minimize metabolic syndrome prevalence.

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Sex- and age-specific associations between major depressive disorder and metabolic syndrome in two general population samples in Germany

Abstract: The data suggest that especially younger (presumably pre-menopausal) females with MDD are more likely to have MetS than those without major depressive disorders, and that age extenuates this association.

Cited by 23 publications

References 65 publications

Depressive symptoms and metabolic syndrome components among older Chinese adults

Depressive symptoms and metabolic syndrome components among older Chinese adults

The Role of Reactive Oxygen Species in the Pathogenesis of Adipocyte Dysfunction in Metabolic Syndrome. Prospects of Pharmacological Correction

Gender differences in metabolic syndrome risk factors among patients with serious mental illness

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