Sex- and Histamine-Dependent Long-Term Cognitive Effects of Methamphetamine Exposure

Acevedo, Summer F.; Esch, Iwan J. P. de; Raber, Jacob

doi:10.1038/sj.npp.1301091

Cited by 45 publications

(84 citation statements)

References 31 publications

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“…Rodent hippocampal development occurs during the first 3 postnatal weeks and models human hippocampal development during the third trimester (Clancy et al , 2007a,b; Winzer-Serhan 2008). Wild type (WT) rats and mice exposed to MA during postnatal hippocampal development show impaired spatial learning and memory (Vorhees et al , 2000, 2007; Williams et al , 2002., 2003a,b; Acevedo et al , 2007) and sensorimotor gating (Acevedo et al , 2007) in adulthood. The long-term cognitive effects of MA at a dose of 5 mg/kg are more severe in WT female than WT male mice, suggesting enhanced sensitivity to the neurotoxic effects of MA in females (Acevedo et al , 2007).…”

Section: Introductionmentioning

confidence: 99%

“…Wild type (WT) rats and mice exposed to MA during postnatal hippocampal development show impaired spatial learning and memory (Vorhees et al , 2000, 2007; Williams et al , 2002., 2003a,b; Acevedo et al , 2007) and sensorimotor gating (Acevedo et al , 2007) in adulthood. The long-term cognitive effects of MA at a dose of 5 mg/kg are more severe in WT female than WT male mice, suggesting enhanced sensitivity to the neurotoxic effects of MA in females (Acevedo et al , 2007). This dose of MA also impairs hippocampal integrity in WT mice, as suggested by reductions in microtubule-associated protein-2 levels (Acevedo et al , 2008b).…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, in the current experiments, we used the same dosing and injection paradigm as used in our previous studies (Acevedo et al, 2007, 2008b). Although we aimed to study effects of methamphetamine during hippocampal development, we recognize the limitations of comparing exposure of mouse or rat pups to drugs of abuse during postnatal hippocampal development to in utero exposure of human fetuses during prenatal hippocampal development.…”

Section: Introductionmentioning

confidence: 99%

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Long-term effects of methamphetamine exposure on cognitive function and muscarinic acetylcholine receptor levels in mice

Siegel¹,

Craytor²,

Raber³

2010

Behavioural Pharmacology

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Exposure to methamphetamine during brain development impairs cognition in humans and rodents. In mice, these impairments are greater in females than males. Genetic factors, such as apolipoprotein E genotype, may modulate the cognitive effects of methamphetamine. Methamphetamine-induced alterations in the brain acetylcholine system may contribute to the cognitive effects of methamphetamine and may also be modulated by apolipoprotein E isoform. We assessed the long-term effects of methamphetamine exposure during brain development on cognitive function and muscarinic acetylcholine receptors in mice, and whether apolipoprotein E isoform modulates these effects. Mice expressing human apolipoprotein E3 or E4 were exposed to methamphetamine (5 mg/kg) or saline once a day from postnatal day 11-20 and behaviorally tested in adulthood. Muscarinic acetylcholine receptor binding was measured in the hippocampus and cortex. Methamphetamine exposure impaired novel location recognition in female, but not male, mice. Methamphetamine-exposed male and female mice showed impaired novel object recognition and increased number of muscarinic acetylcholine receptors in the hippocampus. The cognitive and cholinergic effects of methamphetamine were similar in apolipoprotein E3 and E4 mice. Thus, the cholinergic system, but not apolipoprotein E isoform, might play an important role in the long-term methamphetamine-induced cognitive deficits in adulthood.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Long-term effects of methamphetamine exposure on cognitive function and muscarinic acetylcholine receptor levels in mice

Siegel¹,

Craytor²,

Raber³

2010

Behavioural Pharmacology

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“…When assessed at least 1 week after MA administration, rats and mice that are administered large, binge doses of MA (X4 mg/kg per dose, often multiple times per day) exhibit deficits in several cognitive domains, including object recognition memory (Belcher et al, 2005;Siegel et al, 2010), odor recognition memory (O'Dell et al, 2011), spatial learning (Acevedo et al, 2007;Vorhees et al, 2009), sequential learning (Chapman et al, 2001;Daberkow et al, 2005), path integration learning (Herring et al, 2008), working memory (Mizoguchi et al, 2011), effort discounting (similar to delay discounting) (Kosheleff et al, 2012), and reversal learning (Izquierdo et al, 2010).…”

Section: Animals Exposed To Ma Will Show Cognitive Decline Particulamentioning

confidence: 99%

An Evaluation of the Evidence that Methamphetamine Abuse Causes Cognitive Decline in Humans

Dean

Groman

Morales

et al. 2012

Neuropsychopharmacol

210

127

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Methamphetamine (MA) is one of the most commonly abused illicit substances worldwide. Among other problems, abuse of the drug has been associated with reduced cognitive function across several domains. However, much of the literature has not attempted to differentiate cognitive difficulties caused by MA abuse from preexisting cognitive difficulties that are likely caused by other factors. Here, we address this question, evaluating evidence for a priori hypotheses pertaining to six lines of research: (a) animal studies; (b) crosssectional human studies; (c) a twin study; (d) studies of changes in cognition with abstinence from MA; (e) studies of changes in brain structure and function with abstinence from MA; and (f) studies of the relationship between the severity of MA abuse and the extent of cognitive deficits observed. Overall the findings were mixed, with some support for a causal relationship between MA abuse and cognitive decline, and other findings suggesting that there is no relationship. The preponderance of the data, however, does support the possibility that MA abuse causes cognitive decline, of unknown duration, in at least some users of the drug. When averaged across individuals, this decline is likely to be mild in early-to-middle adulthood. However, moderator variables are likely to contribute to the presence and/or severity of cognitive decline exhibited by a given individual.

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“…The mice were tested at 3 months of age. The results of this study are as described in detail in [48] and summarized below. There were no effects of thioperamide on body weight, exploratory behavior, measures of anxiety, or sensorimotor function.…”

mentioning

confidence: 98%

Histamine receptor-mediated signaling during development and brain function in adulthood

Raber

2007

Cell. Mol. Life Sci.

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Histamine might have an important role in brain development. However, most studies have focused on short-term effects of histamine receptor-mediated signaling on brain function in adulthood. Little is known about the potential long-term effects of histamine receptor-mediated signaling during development on brain function in adulthood. We hypothesize that increased postsynaptic histamine receptor-mediated signaling during development has detrimental effects on brain function in adulthood. Our data support this hypothesis. In the developing mouse brain, histamine H3 receptor blockade, which increases histamine release, has detrimental sex-dependent effects on object recognition, spatial learning in the water maze, and pre-pulse inhibition in adulthood. Our data also support the hypothesis that histamine mediates the detrimental long-term sex-dependent effects of methamphetamine exposure early in life on these brain functions in adulthood. Therefore, increased efforts are warranted to carefully evaluate the effects of drugs that directly or indirectly affect histamine receptor-mediated signaling during development on cognitive function later in life.

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Sex- and Histamine-Dependent Long-Term Cognitive Effects of Methamphetamine Exposure

Cited by 45 publications

References 31 publications

Long-term effects of methamphetamine exposure on cognitive function and muscarinic acetylcholine receptor levels in mice

Long-term effects of methamphetamine exposure on cognitive function and muscarinic acetylcholine receptor levels in mice

An Evaluation of the Evidence that Methamphetamine Abuse Causes Cognitive Decline in Humans

Histamine receptor-mediated signaling during development and brain function in adulthood

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