Sex and Strain Differences in Basal and Induced Aniline Hydroxylase and Ethylmorphine N-Demethylase Activities from Domestic and Wild Rats

Page, John G.; Vesell, E S

doi:10.1159/000136037

Cited by 24 publications

(1 citation statement)

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“…The third group, after getting 50 mg/kg of GPA 1851 orally daily for 4 days, was sacrificed 24 h after the last dose. At the time of sacrifice the livers were removed; hepatic microsomes prepared at 4 °C were examined for aniline hydroxylase activity, ethylmorphine N-demethylase activity, and cytochrome P-450 content, as previously described (Page and Vesell, 1969).…”

Section: Methodsmentioning

confidence: 99%

Differential Effects of GPA 1851 on Hepatic Microsomal Drug Metabolism Dependent on Dosage and Time of Sacrifice

Es¹,

Cj²,

Gt³

et al. 1972

Pharmacology

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Investigations of effects exerted by various compounds on hepatic microsomal mixed function oxidases are frequently designed for and performed under a single set of conditions with respect to dosage and time of sacrifice after drug administration. From these data a generalization may be derived as to whether a particular drug inhibits, induces or produces no change in these enzymes. Limitations of this approach are illustrated by experiments with GPA 1851, an imidazolone derivative with anti-inflammatory properties. Two hours after a single oral dose of 50 mg/kg, rat hepatic microsomal aniline hydroxylase and ethylmorphine N-demethylase activities were markedly reduced, whereas if the rats were sacrificed 24 h after this oral dose, aniline hydroxylase activity and cytochrome P-450 were enhanced. When rats were sacrificed 24 h after the last of 4 daily oral doses of GPA 1851, no significant change occurred in aniline hydroxylase or ethylmorphine N-demethylase activities, but cytochrome P-450 content was elevated.

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Section: Methodsmentioning

confidence: 99%