Sex difference in the association between surrogate markers of insulin resistance and arterial stiffness

Nakagomi, Atsushi; Sunami, Yuko; Kawasaki, Yohei; Fujisawa, Takehiko; Kobayashi, Yoshio

doi:10.1016/j.jdiacomp.2019.107442

Cited by 60 publications

(71 citation statements)

References 24 publications

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“…[8] Nevertheless, previous studies have shown that VAI is more in uential in females. [13,17,18] We, therefore, conducted a strati ed multivariable analysis by sex to con rm these results. All variables with P < 0.05 were considered signi cant in this study.…”

Section: Discussionmentioning

confidence: 87%

“…Previous studies investigating atherosclerosis or cardiovascular diseases have shown similar results, but the cause of these results is not clear. [13,17,18] They speculate that the hormonal difference between males and females or differences in composition of VAT and SAT underlie these results. [17] Based on our ndings, we propose a slightly different reason.…”

Section: Discussionmentioning

confidence: 99%

“…[13,17,18] They speculate that the hormonal difference between males and females or differences in composition of VAT and SAT underlie these results. [17] Based on our ndings, we propose a slightly different reason. Firstly, the relationship between age and VAI may affect this sexual difference.…”

Section: Discussionmentioning

confidence: 99%

“…These meaningful ndings were found only in female participants, consistent with previous studies. [13,17,18] Although the exact pathological mechanisms underlying the relationship between VAI and SBI is not clear. Several plausible mechanisms can be considered.…”

Section: Discussionmentioning

confidence: 99%

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Visceral Adiposity Index is Associated With Silent Brain Infarct in a Healthy Population

Nam¹,

Kwon²,

Jeong³

et al. 2020

Preprint

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Background Visceral adiposity index (VAI) is a novel indicator of the mass and function of visceral adipose tissue, and it has been associated with metabolic disease, cardiovascular disease, and subclinical atherosclerosis; however, there is limited information about its association with cerebrovascular diseases, especially in subclinical pathology. In this study, we evaluated the relationship between VAI and silent brain infarct (SBI) in a healthy population. Methods We evaluated a consecutive series of healthy volunteers over the age of 40 between January 2006 and December 2013. SBI was defined as an asymptomatic, well-defined lesion with a diameter ≥ 3 mm with the same signal characteristics as the cerebrospinal fluid on T1- or T2 weighted images. VAI was calculated using sex-specific equations as described in previous studies, and was based on a number of parameters including waist circumference, triglycerides, high-density lipoprotein cholesterol, and body mass index. Results A total of 2,596 subjects were evaluated (mean age 56y, male sex: 54%), and SBI was found in 218 (8%) participants. In multivariable analysis, VAI (adjusted odds ratio [aOR] = 1.30; 95% confidence interval [CI] = 1.03–1.66; P = 0.030) remained a significant predictor of SBI after adjustment for confounders. On the other hand, visceral adipose tissue area on computed tomography did not show any statistical significance with SBI. The close relationship between VAI and SBI was prominent only in females (aOR = 1.44; 95% CI = 1.00-2.07; P = 0.048). In the evaluation between VAI and the burden of SBI, VAI showed a positive dose-response relationship with the number of SBI lesions (P for trend = 0.037). Conclusions High VAI was associated with a higher prevalence and burden of SBI in a neurologically healthy population, especially in females. Our findings indicate that VAI could be used as a simple and convenient predictor for SBI.

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Visceral Adiposity Index is Associated With Silent Brain Infarct in a Healthy Population

Nam¹,

Kwon²,

Jeong³

et al. 2020

Preprint

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“…(3) Certain studies have also identi ed an important correlation between TyG index and coronary artery calci cation [55], which may be another potential mechanism. (4) The TyG index has been also demonstrated to be related to arterial stiffness evaluated by pulse pressure, brachial-ankle pulse wave velocity and carotid-femoral pulse wave velocity, which has been recognized as cardiovascular risk predictor [10,[56][57][58].…”

Section: Discussionmentioning

confidence: 99%

Impacts of triglycerides-glucose index on prognosis of patients with type 2 diabetes mellitus and non-ST-segment elevation acute coronary syndrome: results from an observational cohort study in China

Zhao

Zhang

Cheng

et al. 2020

Preprint

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Background: The relationship between triglycerides-glucose index (TyG index) and the prevalence and prognosis of cardiovascular disease has been confirmed by former studies. However, it remains uncertain whether TyG index has a prognostic impact in patients with type 2 diabetes mellitus (T2DM) and non-ST-segment elevation acute coronary syndrome (NSTE-ACS) undergoing percutaneous coronary intervention (PCI).Methods: The study retrospectively enrolled 798 patients (mean age: 60.9 ± 8.3 years; 68.3% men) with T2DM and NSTE-ACS who underwent PCI at Beijing Anzhen Hospital from January to December 2015. TyG index was calculated as previously reported: ln [fasting TGs (mg/dL) * FBG (mg/dL) / 2]. The primary endpoint was a composite of adverse events as follows: all-cause death, non-fatal myocardial infarction (MI) and ischemia-driven revascularization.Results: TyG index were significantly higher in patients with a primary endpoint event compared with those without. Multivariate Cox analysis showed that 1-unit increase of TyG index was independently associated with higher risk of primary endpoint, independent of other risk factors [hazard ratio (HR) 3.208 per 1-unit increase, 95% confidence interval (CI) 2.400-4.289, P < 0.001]. The addition of TyG index to a baseline risk model had an incremental effect on the predictive value for adverse prognosis [AUC: baseline risk model, 0.800 vs. baseline risk model + TyG index, 0.856, P for comparison < 0.001; category-free net reclassification improvement (NRI) 0.346, P < 0.001; integrated discrimination improvement (IDI) 0.087, P < 0.001].Conclusions: Increased TyG index is a significant predictor of adverse prognosis in patients with T2DM and NSTE-ACS undergoing PCI. Further studies need to be performed to determine whether interventions for TyG index have a positive impact on improving clinical prognosis.

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Remnant cholesterol for the detection of glucose metabolic states in patients with coronary heart disease angina pectoris

et al. 2022

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Sex difference in the association between surrogate markers of insulin resistance and arterial stiffness

Cited by 60 publications

References 24 publications

Visceral Adiposity Index is Associated With Silent Brain Infarct in a Healthy Population

Visceral Adiposity Index is Associated With Silent Brain Infarct in a Healthy Population

Impacts of triglycerides-glucose index on prognosis of patients with type 2 diabetes mellitus and non-ST-segment elevation acute coronary syndrome: results from an observational cohort study in China

Remnant cholesterol for the detection of glucose metabolic states in patients with coronary heart disease angina pectoris

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