Sex Differences in Abnormal Intrinsic Functional Connectivity After Acute Mild Traumatic Brain Injury

Wang, Shan; Hu, Lingli; Cao, Jieli; We, Huang; Sun, Chuanzhu; Zheng, Dewen; Wang, Zhuonan; Gan, Shuoqiu; Niu, Xuan; Gu, Chenghui; Bai, Guanghui; Ye, Limei; Zhang, Danbin; Zhang, Nu; Yin, Bo; Zhang, Ming; Bai, Lijun

doi:10.3389/fncir.2018.00107

Cited by 10 publications

(18 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Within the CN, acute mTBI patients showed decreased connectivity in the right CAL in this study. This finding was not consistent with the study of Wang et al, suggesting that acute mTBI patients showed increased FC in the CN 10 …”

Section: Discussioncontrasting

confidence: 99%

Disrupted functional network connectivity predicts cognitive impairment after acute mild traumatic brain injury

Shang

et al. 2020

CNS Neurosci Ther

View full text Add to dashboard Cite

Aims This study aimed to detect alterations of brain functional connectivity (FC) in acute mild traumatic brain injury (mTBI) and to estimate the extent to which these FC differences predicted the characteristics of posttraumatic cognitive impairment. Methods Resting‐state fMRI data were acquired from acute mTBI patients (n = 50) and healthy controls (HCs) (n = 43). Resting‐state networks (RSNs) were established based on independent component analysis (ICA), and functional network connectivity (FNC) analysis was performed. Subsequently, we analyzed the correlations between FNC abnormalities and cognitive impairment outcomes. Results Altered FC within the salience network (SN), sensorimotor network (SMN), default mode network (DMN), executive control network (ECN), visual network (VN), and cerebellum network (CN) was found in the mTBI group relative to the HC group. Moreover, different patterns of altered network interactions were found between the mTBI patients and HCs, including the SN‐CN, VN‐SMN, and ECN‐DMN connections. Correlations between functional disconnection and cognitive impairment measurements in acute mTBI patients were also found. Conclusion This study indicated that widespread FNC impairment and altered integration existed in mTBI patients at acute stage, suggesting that FNC disruption as a biomarker may be applied for the early diagnosis and prediction of cognitive impairment in mTBI.

show abstract

Section: Discussioncontrasting

confidence: 99%

Disrupted functional network connectivity predicts cognitive impairment after acute mild traumatic brain injury

Shang

et al. 2020

CNS Neurosci Ther

View full text Add to dashboard Cite

show abstract

“…Some recent resting-state fMRI BOLD connectivity studies has identified disconnection functional coupling between the prefrontal cortex and these regions [40,41], which are consistent with our results. In addition, the CBF disconnection between the right CPL and bilateral ITG as well as the right FG was also been identified in mTBI patients, suggesting a disruption of the cerebellar-subcortical-cortical loop, which is partly consistent with the previous restingstate functional connectivity studies that indicate the CPL-FG disconnection and the abnormality of the cerebellum network in mTBI [42][43][44]. The disconnection of the cerebellum may be related to the functional deficits in cognitive integration in acute mTBI patients.…”

Section: Neural Plasticitysupporting

confidence: 84%

Cerebral Blood Flow and Its Connectivity Deficits in Mild Traumatic Brain Injury at the Acute Stage

Shang

et al. 2020

Neural Plasticity

View full text Add to dashboard Cite

Objective. The influence of cognitive impairment after mild traumatic brain injury (mTBI) on cerebral vascular perfusion has been widely concerned, yet the resting-state cerebral blood flow (CBF) connectivity alterations based on arterial spin labeling (ASL) in mild traumatic brain injury (mTBI) remain unclear. This study investigated region CBF and CBF connectivity features in acute mTBI patients, as well as the associations between CBF changes and cognitive impairment. Materials and Methods. Forty-five acute mTBI patients and 42 health controls underwent pseudocontinuous arterial spin labeling (pCASL) perfusion magnetic resonance imaging (MRI). The alterations in regional CBF and relationship between the CBF changes and cognitive impairment were detected. The ASL-CBF connectivity of the brain regions with regional CBF significant differences was also compared between two groups. Neuropsychological tests covered seven cognitive domains. Associations between the CBF changes and cognitive impairment were further investigated. Results. Compared with the healthy controls, the acute mTBI patients exhibited increased CBF in the bilateral inferior temporal gyrus (ITG) and decreased CBF in the right middle frontal gyrus (MFG), the bilateral superior frontal gyrus (SFG), and the right cerebellum posterior lobe (CPL). In the mTBI patients, significant correlations were identified between the CBF changes and cognitive impairment. Importantly, the acute mTBI patients exhibited CBF disconnections between the right CPL and right fusiform gyrus (FG) as well as bilateral ITG, between the left SFG and left middle occipital gyrus (MOG), and between the right SFG and right FG as well as right parahippocampal gyrus. Conclusion. Our results suggest that acute mTBI patients exhibit both regional CBF abnormalities and CBF connectivity deficits, which may underlie the cognitive impairment of the acute mTBI patients.

show abstract

“…Resting-state fMRI (rs-fMRI), which reflects brain activity while an individual is resting and not performing a specific task, may reveal damage to cognitive function caused by mTBI [10]. Using rs-fMRI, multiple resting-state brain intrinsic networks relevant to the neural mechanisms of mTBI have been demonstrated, such as the default mode network (DMN) [11, 12], executive control network (ECN) [13], and motor network [14]. However, these results were variable due to the application of different approaches to rs-fMRI data analysis and the selection of pre- and post-processing procedures and heterogeneous samples.…”

Section: Introductionmentioning

confidence: 99%

Disrupted brain functional hub and causal connectivity in acute mild traumatic brain injury

Chen

et al. 2019

Aging

View full text Add to dashboard Cite

There have been an increasing number of functional magnetic resonance imaging (fMRI) reports on brain abnormalities in mild traumatic brain injury (mTBI) at different phases. However, the neural bases and cognitive impairment after acute mTBI are unclear. This study aimed to identify brain functional hubs and connectivity abnormalities in acute mTBI patients and their correlations with deficits in cognitive performance. Within seven days after brain injury, mTBI patients (n=55) and age-, sex-, and educational -matched healthy controls (HCs) (n=41) underwent resting-state fMRI scans and cognitive assessments. We derived functional connectivity (FC) strength of the whole-brain network using degree centrality (DC) and performed Granger causality analysis (GCA) to analyze causal connectivity patterns in acute mTBI. Compared with HCs, acute mTBI patients had significantly decreased network centrality in the left middle frontal gyrus (MFG). Additionally, acute mTBI showed decreased inflows from the left MFG to bilateral middle temporal gyrus (MTG), left medial superior frontal gyrus (mSFG), and left anterior cingulate cortex (ACC). Correlation analyses revealed that changes in network centrality and causal connectivity were associated with deficits in cognitive performance in mTBI. Our findings may help to provide a new perspective for understanding the neuropathophysiological mechanism of acute cognitive impairment after mTBI.

show abstract

Sex Differences in Abnormal Intrinsic Functional Connectivity After Acute Mild Traumatic Brain Injury

Cited by 10 publications

References 67 publications

Disrupted functional network connectivity predicts cognitive impairment after acute mild traumatic brain injury

Disrupted functional network connectivity predicts cognitive impairment after acute mild traumatic brain injury

Cerebral Blood Flow and Its Connectivity Deficits in Mild Traumatic Brain Injury at the Acute Stage

Disrupted brain functional hub and causal connectivity in acute mild traumatic brain injury

Contact Info

Product

Resources

About